Arsheen Shared "pharm exam 1" - 21 Picmonics
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pharm exam 1
Lamotrigine
- Indications
- Seizure Treatment
- Bipolar Disorder
- Mechanism of Action
- Blocks Voltage-Gated Na+ Channels
- Side Effect
- Stevens-Johnson Syndrome
1 min
Phenytoin
- Indications
- Status Epilepticus
- Tonic-Clonic Seizures
- Mechanism of Action
- Blocks Na+ Channel Activation
- Inhibition of Glutamate Release
- Class IB Antiarrhythmic
- Side Effects
- Teratogenic
- Macrocytic Megaloblastic Anemia
- Induce Cytochrome P450
- Drug-induced Lupus
- Neuropathy
- Hirsutism
- Gingival Hyperplasia
1 min
Carbamazepine
- Indications
- First-line Seizure Medication
- First Line for Trigeminal Neuralgia
- Mechanism of Action
- Stabilizes Inactive State of Na+ Channels
- Side Effects
- Stevens-Johnson Syndrome
- Induce Cytochrome P450
- Teratogen
- Hepatotoxicity
- Blood Dyscrasias
2 mins
Topiramate
- Indications
- Seizure Treatment
- Migraine Prophylaxis
- Mechanism of Action
- Increase GABA Action
- Blocks Voltage-Gated Na+ Channels
- Side Effects
- Kidney Stones
- Weight Loss
- Sedation
1 min
Ethosuximide
- Indications
- First Line Absence Seizure Treatment
- Mechanism of Action
- Blocks Thalamic T-Type Ca2+ Channels
- Side Effects
- Stevens-Johnson Syndrome
- Fatigue
- Diarrhea
32 secs
Pregabalin (Lyrica)
- Mechanism
- GABA Analog
- Indications
- Seizures
- Neuropathic Pain
- Fibromyalgia
- Side Effects
- Headache
- Dizziness
- Ataxia
- Somnolence (Fatigue)
- Weight Gain
- Angioedema
- Rhabdomyolysis
- Considerations
- Dependence
2 mins
Levetiracetam
- Mechanism of Action
- SV2A Receptor Antagonist
- Modulates GABA and Glutamate
- Inhibits Voltage-Gated Ca2+ Channels
- Indication
- Partial (Focal) Seizures
- Tonic-Clonic Seizures
- Myoclonic Seizures
- Side Effects
- Psychiatric Symptoms
- Lethargy
- Headache
- Contraindications
- Chronic Kidney Disease
3 mins
Valproic Acid (Valproate) Side Effects
- V-A-L-P-R-O-A-T-E
- Vomiting
- Alopecia
- Liver Toxicity
- Pancreatitis/Pancytopenia
- Retain Fat (Weight Gain)
- Oedema (Edema)
- Appetite Increase
- Tremor
- Enzyme Inhibitor (P450)
2 mins
Valproic Acid
- Indications
- First Line Tonic-Clonic Seizure Treatment
- Bipolar Disorder
- Migraine Prophylaxis
- Mechanism of Action
- Increases GABA Concentration
- Blocks Voltage-Gated Na+ Channels
- Side Effect
- GI Distress
- Contraindication
- Contraindicated in Pregnancy
1 min
Gabapentin
- Primary Indication
- Seizure Treatment
- Secondary Indications
- Peripheral Neuropathy
- Postherpetic Neuralgia
- Bipolar Disorder
- Migraine Prophylaxis
- Characteristics
- Inhibits Voltage-Gated Ca2+ channels
- Designed as a GABA Analog
- Side Effects
- Ataxia
- Sedation
2 mins
Long-acting Benzodiazepines
- Drug Names
- Lorazepam
- Diazepam
- Clonazepam
- Chlordiazepoxide
- Indications
- Insomnia
- Anxiety
- Seizures
- Eclampsia
- Alcohol Withdrawal
- Considerations
- Half-life > 24 Hours
- Dependence
3 mins
Short-acting Benzodiazepines
- Mnemonic
- ATOM
- Drug Names
- Alprazolam
- Triazolam
- Oxazepam
- Midazolam
- Indications
- Anesthesia Induction
- Insomnia
- Anxiety
- Considerations
- Half-life < 12 Hours
- Dependence
2 mins
Sumatriptan
- Mechanism of Action
- Short Half-Life
- 5-HT Agonist
- Inhibits Trigeminal Nerve Activation
- Induces Vasoconstriction
- Indications
- Migraine
- Cluster Headache
- Side Effects
- Increased Risk of Serotonin Syndrome
- Paresthesias
- Coronary Vasospasm
- Contraindication
- Prinzmetal's Angina
- Coronary Artery Disease (CAD)
3 mins
Buspirone
- Indications
- Generalized Anxiety
- Mechanism of Action
- Releases Dopamine and NE
- Stimulates 5-HT1A receptors
- Side Effects
- Low Side Effect Profile
- Safer with Alcohol than Other Anxiolytics
1 min
Malignant Hyperthermia
- Inheritance
- Autosomal-Dominant
- Pathophysiology and causes
- Ryanodine Receptor 1 Mutation
- Inhaled Anesthetics
- Succinylcholine
- Symptoms
- Autonomic Instability
- Muscle Rigidity
- Treatment
- Dantrolene
2 mins
Malignant Hyperthermia vs. Neuroleptic Malignant Syndrome vs. Serotonin Syndrome
- Autonomic Instability
- Muscle Rigidity
- Malignant Hyperthermia
- Ryanodine Receptor 1 Mutation
- Inhaled Anesthetics
- Succinylcholine
- Dantrolene
- Neuroleptic Malignant Syndrome
- Antidopaminergic Medications
- Hyporeflexia
- Myoglobinuria
- Dantrolene
- Serotonin Syndrome
- Serotonergic Medications
- Hyperreflexia
- Clonus
- Cyproheptadine
3 mins
Serotonin Syndrome Assessment
- Mild Signs & Symptoms
- Restlessness
- Diaphoresis
- Tachycardia
- Hypertension
- Diarrhea
- Moderate Signs & Symptoms
- Hyperthermia
- Decreased Level of Consciousness
- Muscle Rigidity
- Severe Signs & Symptoms
- Seizure and Coma
- Treatment
- Cyproheptadine
2 mins
Ondansetron
- Indications
- Postoperative Vomiting
- Chemotherapy-induced Nausea and Vomiting
- Mechanism
- 5-HT3 Serotonergic Antagonist
- Centrally-acting Antiemetic
- Side Effects
- Headache
- Constipation
- QT Prolongation
1 min
Selective Serotonin Reuptake Inhibitor (SSRI) Overview
- Indications
- Depression
- Anxiety
- Mechanism of Action
- Selective Serotonin Reuptake Inhibitors
- Drugs
- Paroxetine
- Sertraline
- Escitalopram
- Fluoxetine
- Side Effects
- Sexual Dysfunction
- Serotonin Syndrome
- Treat with Cyproheptadine
2 mins
Serotonin Norepinephrine Reuptake Inhibitors (SNRIs)
- Indications
- Depression
- Diabetic Peripheral Neuropathy
- Duloxetine
- Panic and Anxiety
- Venlafaxine
- Mechanism of Action
- Inhibits Reuptake of Serotonin and NE
- Side Effects
- Hypertension
- Insomnia
- Nausea and Vomiting
- Decreased Libido
1 min
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