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General Physiology - Neuromuscular Diseases
Multiple Sclerosis Interventions
Dimethyl Fumarate (Tecfidera)
Multiple Sclerosis Features and Mechanisms
Twice as often in Women
Presents in 20's and 30's
Unknown mechanism, genetic factor
Autoimmune Demyelination of CNS
White Matter of Brain and Spinal Cord
T Cell Mediated Inflammation
Multiple Sclerosis Symptoms and Diagnosis
Urinary and Fecal Incontinence
Motor Issues (Intention Tremor, Paresis)
Numbness and Pain
Gold Standard = Plaques on MRI
Increased CSF Immunoglobulins (IgG)
Guillain-Barre Syndrome Assessment
Paresthesias (Pins and Needles)
Labile Blood Pressure
Loss of Bowel and Bladder Control
Aggressive Airway Management
Antibodies to Acetylcholine Receptor
Weakness with Muscle Use
Autoantibody to the Presynaptic Calcium Channel on Motor Neurons
Inhibits Acetylcholine (ACh) Release at Neuromuscular Junction
Small Cell Lung Cancer
Proximal Muscle Weakness
Improves with Muscle Use
Extraocular Muscle Sparing
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