Daniel Shared "Pharm Exam 3, Antimicrobials" - 64 Picmonics
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Pharm Exam 3, Antimicrobials
NRTIs (Nucleoside Reverse Transcriptase Inhibitors)
- Indications
- HIV
- Pregnancy and Prophylaxis given ZDV
- Mechanism
- Inhibit Nucleotide Binding to Reverse Transcriptase
- Chain Termination
- Require Phosphorylation
1 min
NNRTIs (Non-nucleoside Reverse Transcriptase Inhibitors)
- Indications
- HIV
- Mechanism
- Do Not Require Intracellular Metabolism
- Inhibits Reverse Transcriptase
- Side Effects
- Rash
- Hepatotoxicity
- Vivid Dreams and CNS Symptoms
- Contraindication
- Pregnancy
2 mins
HAART
- HIV
- Begin at Diagnosis
- 3 Drugs
- 2 NRTIs (Nucleoside Reverse Transcriptase Inhibitors)
- And one of the following:
- NNRTI (Non-Nucleoside Reverse Transcriptase Inhibitor)
- or Protease Inhibitor
- or Integrase Inhibitor
1 min
Integrase Inhibitors
- -gravir Suffix
- Indications
- HIV
- Mechanism
- Blocks Insertion of Viral Genome
- Inhibit Actions of Integrase
- Side Effects
- Hypercholesterolemia
- Increased LFT's
- Insomnia
- Increased Creatine Kinase (CK)
1 min
Protease Inhibitors
- End in "-navir"
- Indications
- HIV/AIDS
- Hepatitis C
- Mechanism
- Inhibit Protease
- Unable to Cleave Proteins
- Inhibits Maturation of New Virus
- Side Effects
- GI Distress
- Nephropathy
- Lipodystrophy
- Hyperglycemia
3 mins
NRTIs for HIV (Drug Names)
- Nucleoside Analog
- DEALSZ
- Didanosine (DDI)
- Emtricitabine (FTC)
- Abacavir (ABC)
- Lamivudine (3TC)
- Stavudine (d4T)
- Zidovudine (ZDV)
- Nucleotide Analog
- Tenofovir (TDF)
2 mins
Acyclovir (Zovirax)
- Mechanism
- Guanosine Analog
- Inhibits Viral Replication
- Thymidine Kinase Activation
- Indications
- Herpes Simplex Virus (HSV)
- Varicella Zoster Virus (VZV)
- Side Effects (Oral)
- Headache
- GI Distress
- Side Effects (IV)
- CNS Toxicity
- Nephrotoxicity (Crystalline Nephropathy)
- Considerations
- Prevents Recurrent Episodes
- Slow IV Infusion
2 mins
Genital Herpes
- Mechanism
- Herpes Simplex Virus 1 and 2 (HSV)
- Assessment
- May Be Asymptomatic
- Oral or Genital Lesions
- Vesicles in Clusters
- Pain
- Flu-like Symptoms
- Antiviral Medications
- Acyclovir
- Valacyclovir
- Famciclovir
- Considerations
- Infectious During Recurrences
2 mins
Ganciclovir
- Indications
- Cytomegalovirus (CMV)
- Immunocompromised
- Mechanism
- Guanosine Analog
- Disrupts DNA Synthesis
- Inhibits Viral DNA Polymerase
- Side Effects
- Hematologic Effects
- Nephrotoxicity
1 min
Zanamivir (Relenza) and Oseltamivir (Tamiflu)
- Indications
- Influenza A and B
- Treatment and Prophylaxis
- Mechanism
- Inhibits Release of New Virus
- Inhibits Influenza Neuraminidase
1 min
Metronidazole
- Mechanism of Action
- Bactericidal
- Forms Free Radical Toxic Metabolites
- Damages DNA
- Indications
- Giardia lamblia
- Entamoeba Histolytica
- Trichomonas
- Gardnerella
- Anaerobes
- Side Effects
- Metallic taste
- Disulfiram like Reaction with Alcohol
2 mins
Entamoeba histolytica
- Pathophysiology
- Protozoa
- Amebiasis
- Ingestion of Cysts in Food and Water
- Signs and Symptoms
- Bloody Diarrhea
- Flask-Shaped Ulcer
- Liver Abscess
- Anchovy Paste
- RUQ Pain
- Diagnosis
- RBCs in Cytoplasm of Trophozoite
- Cyst With Four Nuclei
- Treatment
- Metronidazole
- Iodoquinol
3 mins
Giardia lamblia
- Characteristics
- Protozoa
- Ingestion of Cysts
- Seen in Campers
- Daycare Centers
- Mental Hospitals
- Infects Small Intestine
- Signs and Symptoms
- Bloating
- Flatulence
- Fatty Diarrhea
- Diagnosis
- Crescent-shaped Protozoa Adjacent to Epithelial Brush Border
- Predisposed if Low IgA
- Treatment
- Metronidazole
3 mins
Scabies
- Pathophysiology
- Sarcoptes Scabiei Mite
- Signs & Symptoms
- Pruritus
- Papules with Burrows
- Webs of Fingers and Toes
- Axilla and Nipples
- Diagnosis
- Skin Scraping
- Dermoscopy
- Mites and Eggs on Magnification
- Treatment
- Permethrin Cream
- Oral Ivermectin
- Lindane Cream
- Considerations
- Wash All Linens In Hot Water
3 mins
Lice
- Clinical Features
- Pediculosis Capitis, Corporis, Pubis
- Pruritis
- Hyperpigmentation
- Louse-borne Diseases
- Trench Fever
- Bartonella Quintana
- Epidemic Typhus
- Rickettsia Prowazekii
- Relapsing Fever
- Borrelia Recurrentis
- Treatment
- Permethrin
- Malathion
- Ivermectin
3 mins
Hookworm Infection
- Characteristics
- Necator Americanus
- Ancylostoma spp
- Nematode (Roundworm)
- Mode of transmission
- Larvae in Soil Penetrate Skin
- Pathophysiology
- Larvae Migrate To Lungs
- Larvae Mature In The Intestine
- Risk Factors
- Walking Barefoot On Contaminated Ground
- Signs & Symptoms
- Cutaneous Symptoms
- Microcytic Anemia
- Treatment
- Albendazole
- Pyrantel Pamoate
4 mins
Ascariasis Clinical Features and Management
- Early Clinical Manifestations
- Cough
- Eosinophilic Pneumonitis (Loffler Syndrome)
- Late Clinical Manifestations
- GI Upset
- Bowel or Biliary Obstruction
- Worms in Stool
- Diagnosis
- Stool Ova and Parasite Studies
- Management
- Albendazole
- Pyrantel Pamoate In Pregnancy
5 mins
Strongyloides Stercoralis
- Pathophysiology
- Nematode (Roundworm)
- Larvae in Soil Penetrate Skin
- Uncomplicated Disease
- GI Distress
- Loffler's Syndrome
- Dermatitis
- Disseminated Disease
- Immunosuppressed
- Treatment
- Ivermectin
- Albendazole
2 mins
Pinworm (Enterobius Vermicularis)
- Pathophysiology
- Nematode (Roundworm)
- Ingestion of Eggs
- Intestinal Infection
- Anal Pruritus
- Diagnosis
- Scotch Tape Test
- Treatment
- Albendazole
- Pyrantel Pamoate
2 mins
Taenia Solium
- Pathophysiology
- Cestode (Tapeworm)
- Taeniasis
- Ingestion of Larvae in Undercooked Pork
- Asymptomatic, in Bowels
- Cysticercosis
- Ingestion of Cestode Eggs
- Skin, CNS and Muscles
- Treatment
- Albendazole
- Praziquantel
1 min
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