Daniel Shared "Endocrine System Part 2" - 34 Picmonics
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Endocrine System Part 2
Insulin Synthesis
- Synthesis
- Preproinsulin
- Rough Endoplasmic Reticulum
- Proinsulin
- Golgi Body
- Beta Cells Release Insulin
- Beta Cells Release C-peptide
- Clinical Relevance
- Insulinoma
- Sulfonylureas
- Surreptitious Insulin Use
2 mins
MEN 1 (Multiple Endocrine Neoplasia)
- Pathophysiology
- Autosomal Dominant
- Menin Mutation (Tumor Suppression Gene)
- Chromosome 11
- Signs and Symptoms
- Pancreatic Endocrine Tumors
- Pituitary Tumors
- Parathyroid Adenomas
2 mins
MEN 2A (Multiple Endocrine Neoplasia)
- Pathophysiology
- Autosomal Dominant
- RET Gene
- Signs and Symptoms
- Medullary Thyroid carcinoma
- Calcitonin
- Parathyroid
- Pheochromocytoma
45 secs
MEN 2B (Multiple Endocrine Neoplasia)
- Pathophysiology
- RET Gene
- Autosomal Dominant
- Signs and Symptoms
- Medullary Thyroid Carcinoma
- Pheochromocytoma
- Mucosal Neuromas
- Marfanoid Body Habitus
2 mins
Thyroid Nodule Assessment
- Initial Tests
- Thyroid-Stimulating Hormone (TSH)
- Ultrasound
- Normal / Elevated TSH
- Fine Needle Aspiration
- Most Accurate Test
- Decreased TSH
- Radioactive Iodine Uptake (RAIU)
- Hot Nodules Rarely Malignant
- Free T3 and T4
- Considerations
- Repeat Ultrasound 6 -18 Months
2 mins
Hypothyroidism Assessment
- Assessment
- Weight Gain - Edema
- Lethargy
- Cold Intolerance
- Bradycardia
- Hypertension
- Brittle Nails and Dry Skin
- Constipation
- Goiter
- Prolonged Menses
- Slowed Thinking
- Diagnostic Tests
- Decreased Free T4
- Increased TSH
2 mins
Hypothyroidism Intervention
- Medications
- Levothyroxine (Synthroid)
- Liothyronine (Cytomel)
- Complication
- Myxedema Coma
- Nursing Considerations
- Lifelong Replacement Hormone
- Monitor Vital Signs
- Fluids and Fiber
- Low Calorie, Low Fat Diet
- Medication Education
- No Switching Brands
2 mins
Hyperthyroidism Assessment
- Assessment
- Heat Intolerance
- Exophthalmos
- Warm, Moist Skin and Silky Hair
- Tremors
- Goiter
- Diarrhea
- Weight Loss
- Tachycardia
- Hypertension
- Amenorrhea
- Diagnosis
- Decreased TSH with Elevated Free T4
- Radioactive Iodine Uptake (RAIU)
2 mins
Hyperthyroidism Interventions
- Drug Therapy
- Propylthiouracil (PTU)
- Methimazole (Tapazole)
- Iodine
- Beta Blockers
- Other Therapies
- Radioiodine Ablation
- Thyroidectomy
- Complications
- Thyrotoxicosis
- Post-Surgery Hypocalcemia
2 mins
Levothyroxine
- Indications
- Hypothyroidism
- Myxedema Coma
- Mechanism of Action
- Isomer of Thyroid Hormone (T4)
- T3 has Higher Potency
- Side Effects
- Hyperthyroid Symptoms
57 secs
Glucagon (GlucaGen)
- Mechanism
- Increases Glucose
- Indications
- Hypoglycemic Emergency
- Side Effects
- Nausea and Vomiting
- Considerations
- Reconstitute Powder
- Consume Oral Carbohydrates
- 50% Dextrose IV (If No Effect)
2 mins
Insulin Regulation
- Master Regulator
- Glucose
- Incretins Released with Oral Glucose
- GLP-1
- GIP
- Positive Regulators
- Beta-2 Receptor Stimulation
- M3 Acetylcholine Receptor Stimulation
- Negative Regulators
- Alpha-2 Receptor Stimulation
- Somatostatin
2 mins
Insulin
- Rapid Acting
- Insulin Lispro (Humalog)
- Insulin Aspart (Novolog)
- Insulin Glulisine (Apidra)
- Short Acting
- Regular Insulin (Humulin R)
- Intermediate Acting
- Isophane NPH (Humulin N)
- Long Acting
- Detemir (Levemir)
- Glargine (Lantus)
2 mins
Insulinoma
- Characteristics
- Pancreatic Neuroendocrine Tumor
- Benign
- Associated with MEN-1
- Clinical Features
- Whipple Triad
- Symptoms of Hypoglycemia
- Hypoglycemia During Episode
- Relief with Glucose
- Diagnosis
- Increased C-peptide
- Management
- Surgery
- Octreotide
- Diazoxide
2 mins
Zollinger-Ellison Syndrome Disease
- Pathophysiology
- Gastrin-Secreting Tumor
- Increased Gastric Acid
- Recurrent Peptic Ulcers
- MEN Type 1
- Symptoms
- Abdominal Pain
- Heartburn (Pyrosis)
- Diarrhea
3 mins
Glucagonoma
- Characteristics
- Pancreatic Neuroendocine Tumor
- Originates from A Cells
- Clinical Features
- Weight Loss
- Necrolytic Migratory Erythema
- Depression
- Diarrhea
- Deep Vein Thrombosis
- Diabetes Mellitus
- Diagnosis
- Increased Glucagon
- Abdominal CT
- Management
- Octreotide
- Surgical Resection
2 mins
Somatostatinoma
- Characteristics
- Pancreatic Neuroendocrine Tumor
- Originates from Delta Cells
- Clinical Features
- Steatorrhea
- Gallstones
- Hyperglycemia
- Diagnosis
- Increased Somatostatin
- Abdominal CT or MRI
- Management
- Octreotide
- Surgical Resection
- Chemotherapy
2 mins
VIPoma
- Characteristics
- Pancreatic Neuroendocrine Tumor
- Secretes Vasoactive Intestinal Polypeptide (VIP)
- Clinical Features
- GI Distress
- Watery Diarrhea
- Hypokalemia
- Achlorhydria
- Management
- Octreotide
- Surgical Resection
- Associations
- Multiple Endocrine Neoplasia Type 1 (MEN 1)
2 mins
Gestational Diabetes
- Signs and Symptoms
- Usually Asymptomatic
- Fetal Macrosomia
- Polyhydramnios
- Diagnosis
- Glucose Intolerance After 24 Weeks Gestation
- 3-hr 100g Glucose Tolerance Test
- Treatment
- Diet and Exercise
- Close Glucose Monitoring
- Insulin
- Ultrasound (or Nonstress Test (NST))
- Delivery
2 mins
Metabolic Syndrome
- Assessment
- Dyslipidemia
- Central Obesity
- Insulin Resistance
- Hypertension
- Increased C-Reactive Protein (CRP)
- Increased Fibrinogen
- Considerations
- Increased Risk Cardiovascular Disease
1 min
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