Kayla Shared "PHARM B3 L7 Antiparasitic" - 15 Picmonics

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PHARM B3 L7 Antiparasitic

Plasmodium General
Characteristics
Protozoa
Malaria
Anopheles Mosquito
Signs and Symptoms
Cyclic Fever
Headache
Anemia
Splenomegaly
Diagnosis
Blood Smear
Treatment
Chloroquine
Mefloquine for Resistant Types
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3 mins
Plasmodium Specific
Malariae
Fever Every Three Days
Vivax/Ovale
Fever Every Two Days
Duffy Antigen Binding Site
Duffy often absent in Black Population
Primaquine treats dormant form in liver
Falciparum
Most severe
Irregular Cycles
Occludes capillaries in the brain, kidneys, and lungs
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4 mins
Clindamycin
Mechanism of Action
Bacteriostatic
Binds 50S Ribosomal Subunit
Blocks Translocation
Indications
Anaerobic Infections above the Diaphragm
Aspiration Pneumonia
Lung Abscess
Side Effects
Can Cause Pseudomembranous Colitis
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1 min
Toxoplasma gondii
Characteristics
Protozoa
Cysts in meat or cat feces
Signs and Symptoms
Brain Abscess in HIV Patients
Ring-enhancing brain lesions
Crosses placenta in pregnant women
Congenital TORCH infection
Treatment
Pyrimethamine
Sulfadiazine
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2 mins
Sulfonamides Mechanisms
Bacteriostatic
Gram-Positive
Gram-Negative
Nocardia
Chlamydia
PABA antimetabolites
Inhibit dihydropteroate synthase
Sulfamethoxazole
Sulfisoxazole
Sulfadiazine
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1 min
Sulfonamides Side Effects
Side Effects
Hypersensitivity
Nephrotoxicity
Photosensitivity
Kernicterus in Infants
Displaces Warfarin from Albumin
Considerations
Hemolysis with G6PD Deficiency
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3 mins
Metronidazole
Mechanism of Action
Bactericidal
Forms Free Radical Toxic Metabolites
Damages DNA
Indications
Giardia lamblia
Entamoeba Histolytica
Trichomonas
Gardnerella
Anaerobes
Side Effects
Metallic taste
Disulfiram like Reaction with Alcohol
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2 mins
Macrolides
Bacteriostatic
Erythromycin
Azithromycin
Clarithromycin
Bind to 23S rRNA of 50S subunit
Inhibit protein synthesis by blocking translocation
Gram-Positive Cocci
Atypical pneumonia
Chlamydia
Resistance by methylation of 23S rRNA binding
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1 min
Echinococcus Granulosus
Pathophysiology
Cestode (Tapeworm)
Ingestion of Eggs from Dog Feces
Hydatid Cysts in Liver
Fibrosis and Necrosis
Anaphylaxis if Antigens Released
Treatment
Albendazole
Surgical Removal
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1 min
Taenia Solium
Pathophysiology
Cestode (Tapeworm)
Taeniasis
Ingestion of Larvae in Undercooked Pork
Asymptomatic, in Bowels
Cysticercosis
Ingestion of Cestode Eggs
Skin, CNS and Muscles
Treatment
Albendazole
Praziquantel
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1 min
Loa Loa
Pathophysiology
Nematode (Roundworm)
Fly Bite
Calabar Swellings in Skin
Conjunctiva
Treatment
Diethylcarbamazine (DEC)
Albendazole
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1 min
Schistosoma
Pathophysiology
Trematode (Fluke)
Snail-infested Water
Intense Immune Response
Intestinal Disease
Hepatosplenic Granuloma
Squamous Cell Cancer of the Bladder
Diagnosis
Parasitic Antigens via ELISA
Treatment
Praziquantel
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2 mins
Clonorchis Sinensis
Pathophysiology
Trematode (Fluke)
Undercooked Fish
Biliary Tract Inflammation
Pigmented Gallstones
Associated with Cholangiocarcinoma
Treatment
Praziquantel
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1 min
Diphyllobothrium Latum
Pathophysiology
Cestode (Tapeworm)
Ingestion of Larvae from Raw Fish
Competes for Vitamin B12
Megaloblastic Anemia
Treatment
Praziquantel
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1 min
NSAIDs
Indications
Anti-inflammatory
Analgesic
Fever
Closure of PDA
Mechanism of Action
Reversible Inhibition of COX-1 and COX-2
Block Prostaglandin Synthesis
Side Effects
Interstitial Nephritis
Gastric Ulcer
Renal Ischemia
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1 min

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