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M4: M4. Immunological Pathology: Adaptive Immunity, Alternations, Infection (II)
Cell-mediated Adaptive Immune Response
Characteristics
Macrophages and Dendritic Cells Present Antigens
T Cell Develops Antigen Specificity
Regulatory T Cells Suppress Response
Memory T Cells Cause Faster Secondary Response
Cytotoxic T Cells Lyse Infected Cells
Infected Cells Present Antigen On Surface
2 mins
Humoral Adaptive Immunity
Characteristics
B Cell Binds Free Floating Antigen
B Cell Presents Antigen to Helper T Cell
Helper T Cells Help B Cells Develop Antigen Specificity
Plasma B Cells Secrete Antibodies
Memory B Cells Cause Faster Secondary Response
2 mins
Killed (Inactivated) Whole Vaccines
Characteristics
Require Booster Shots
Vaccines
Mostly Humoral Immune Response
Polio (Salk)
Rabies
Cholera
Hepatitis A
54 secs
Pediatric Vaccinations - Age 2 Months
2 B DR HIP
Hepatitis B
DTaP - Diphtheria Tetanus acellular Pertussis
RV - Rotavirus
HiB - Haemophilus Influenzae Type B
IPV - Inactivated Polio Vaccine
PCV - Pneumococcal
1 min
Killed (Inactivated) Fractional Protein Vaccines
Subunit Vaccines
Subunit
Influenza (Intramuscular)
Bordetella Pertussis
Hepatitis B
Human Papillomavirus (HPV)
Bacillus anthracis (Anthrax)
Toxoid Vaccines
Toxoid
Corynebacterium diphtheriae (Diphtheria)
Clostridium tetani (Tetanus)
Considerations
DTaP and Tdap
3 mins
Live Attenuated Vaccines
Characteristics
Humoral and Cellular Immune Response
May Revert to Virulent Form
Do Not Require Boosters
Vaccines
Varicella (Chickenpox)
Zoster (Shingles)
Polio (Sabin)
Smallpox
Yellow Fever
Influenza (Intranasal)
MMR
Rotavirus
Typhoid Fever (Oral)
BCG (Bacillus Calmette-Guérin)
4 mins
Pediatric Vaccinations - Age 4 Months
4 DR HIP
DTaP - Diphtheria Tetanus acellular pertussis
RV - Rotavirus
HiB - Haemophilus Influenzae Type B
IPV - Inactivated Polio Vaccine
PCV - Pneumococcal
1 min
Pediatric Vaccinations - Age 6 Months
B DR HIP In 6 Months
Hepatitis B
DTaP - Diphtheria Tetanus acellular pertussis
RV - Rotavirus
HiB - Haemophilus Influenzae Type B
IPV - Inactivated Polio Vaccine
PCV - Pneumococcal
Influenza
2 mins
Toxoid Vaccines
Consist of Toxins Released From a Pathogen
May Require Boosters
Safe In Immunocompromised Patients
Corynebacterium Diphtheriae Vaccine
Tetanus Vaccine
Bordetella Pertussis Vaccine
2 mins
Disease Prevention Stages
Primordial
Target Social Conditions
Primary
Prevent Disease in Healthy Individuals
Secondary
Screen Healthy-Appearing Individuals
Tertiary
Treatment of Patients with Disease
Quaternary
Prevent Overtreatment
2 mins
Beta-Lactamase Inhibitors
Considerations
Often Combined with Penicillin Antibiotics
Drug Names
Clavulanic Acid
Sulbactam
Tazobactam
51 secs
Anti-glomerular Basement Membrane Antibodies
Glomerulonephritis
Goodpasture's Disease
Linear immunofluorescence
Hemoptysis
Hematuria
1 min
Anticentromere Antibodies
Autoimmune Disorders
CREST Syndrome (Limited Scleroderma)
Diffuse Scleroderma
49 secs
Antihistone Antibodies
Drug-induced Lupus
SHIPP Acronym
Sulfonamides
Hydralazine
Isoniazid (INH)
Phenytoin
Procainamide
1 min
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