Matthew Shared "Musculo- Dermatology" - 21 Picmonics
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10-30% BSA Overlaps with Toxic Epidermal Necrolysis (TEN)
Affects Skin and Mucous Membranes
Sloughing of Skin
High Mortality Rate
IVIG (Intravenous Immunoglobulin)
Papules or Plaques
Precursor to Squamous Cell Carcinoma
Pregnancy or OCP Use
30-60 year olds
Signs & Symptoms
Plaques or Papules
Purple & Polygonal
Often Mucosal or Genital Involvement
Sawtooth Infiltrate of Lymphocytes
Hepatitis C Association
Preceded by Upper Respiratory Tract Infection
Single "Herald Patch"
"Christmas Tree" Distribution
Plaques with Collarette Scale
Self-resolving in 6-8 Weeks
Basal Cell Carcinoma of the Skin
Most Common Skin Cancer
2/3 of Cases Due to UV Light Exposure
Pink, Pearl-like Lesions
Commonly Upper Lip
Mohs Micrographic Surgery
Squamous Cell Carcinoma of the Skin
2nd Most Common Skin Cancer
UV Light Exposure
Ulcerative Red Lesion
Precursor Actinic Keratosis
Commonly Lower Lip
Biopsy shows Keratin Pearls
Mohs Micrographic Surgery
Diameter > 6mm
Evolution over time
S-100 Tumor Marker
LDH (Lactate Dehydrogenase) Screens for Metastasis
Wide Local Excision
Types of Malignant Melanoma
Most Common Cause of Melanoma
Aggressive and Rapidly Arising
Asians and African Americans
Sun Exposed Areas
Rare blood vessel malignancy typically occurring in the head, neck, and breast areas. Endothelial origin.
Usually in elderly, on sun-exposed areas.
Associated with radiation therapy and chronic postmastectomy lymphedema.
Hepatic angiosarcoma associated with vinyl chloride (like in PVC pipes) and arsenic exposures. Also associated with Thorotrast exposures.
Very aggressive and difficult to resect due to delay in diagnosis
Usually asymptomatic, may have RUQ pain or may impinge on nearby structures; excellent prognosis with resection
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