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Pharmacology
Routes of Administration Part One
Enteral Administration
Oral
Sublingual
Buccal
Rectal
Tubes
Topical or Mucous Membrane Administration
Transdermal
Drops/Spray
Vaginal
Inhalation Administration
Inhalation
2 mins
Routes of Administration Part Two (Parenteral)
Parenteral Administration
Intradermal
Subcutaneous
Intramuscular (IM)
Intravenous
Epidural
Intrathecal
Intraosseous
Intraperitoneal
2 mins
Peak and Trough
Peak
Highest Concentration
Trough
Lowest Level of Therapeutic Range
Obtain Before Next Dose
Half-Life
2 mins
Eye Medication Administration
Procedure
Supine with Neck Hyperextended
Wash Away Crusts
Cotton Ball on Cheekbone
For Ophthalmic Drops
Instill Drops into Conjunctival Sac
Repeat if Missed or Patient Blinks
5 Minutes Before 2nd Medication
For Ophthalmic Ointment
Thin Stream Along Inner Edge
Inner Canthus to Outer Canthus
2 mins
Ear Drops Medication Administration
Indications
Earwax Buildup
Ear Infections
Pulling The Pinna
Child - Back and Downward
Adult - Back and Upward
Procedure
Side-Lying with Ear Up
Instill Medication
Stay for 2-3 Minutes
Nursing Considerations
Room Temperature
May Massage Tragus
Perforated Eardrum
2 mins
Eye Medications
cycloplegics/mydriatics
Anticholinergics
Phenylephrines
allergic conjunctivitis
Age-Related Macular Degeneration (AMD)
2 mins
Patient’s Rights
Patient’s Rights When Hospitalized
Respectful Care
Information
Consent or Refuse Treatment
Continuity of Care
Privacy and Confidentiality
Medical Record Review
Consent or Refuse Part in Research
Health Alternatives
Explanation of Charges and Bills
3 mins
Fluoroquinolones
End in "-floxacin"
Mechanism of Action
Bactericidal
Indications
Variety of Infections
Side Effects
GI Distress
Photosensitivity
Achilles Tendon Rupture
Contraindications
Pregnancy
Children
Myasthenia Gravis
Considerations
Avoid Milk Products or Antacids
Slow IV Infusion
2 mins
Ampicillin and Amoxicillin
Mechanism
Aminopenicillin
Indications
Broad Spectrum Penicillin
Gram-Positive and Some Gram-Negative Infections
Side Effects
Rash
Ampicillin Rash in EBV
Diarrhea
Pseudomembranous Colitis
Allergic Reaction
Considerations
No Effect Against Staph Aureus
Often Combined with Beta-Lactamase Inhibitor
2 mins
Aminoglycoside Overview
End in "-mycin"
GNATS
Gentamicin
Neomycin
Amikacin
Tobramycin
Streptomycin
Mechanism of Action
Bactericidal
Requires Oxygen for Uptake
Synergistic with β-lactam Antibiotics
Indications
Severe Gram-Negative Infections
Bowel Surgery Prep
MECHANISM OF RESISTANCE
Bacterial Transferases
3 mins
Aminoglycoside Side Effects
Side Effects
Ototoxicity
Nephrotoxicity
Respiratory Paralysis
Contraindications
Pregnancy
Considerations
Peak and Trough
Never Mix with Penicillin in Same IV
2 mins
Cephalosporins
Starts with "Cef-"
Mechanism of Action
Bactericidal
Indications
Gram-Positive and Gram-Negative Infections
Side Effects
Allergic Reactions
Thrombophlebitis
Bleeding
Contraindications
Renal Impairment
Considerations
Avoid IV Calcium with Ceftriaxone
No Alcohol
2 mins
Penicillin
Mechanism of Action
Weakens Cell Wall
Indications
Gram-Positive Infections
Prophylaxis
Side Effects
Pain at IM Injection Site
Allergic Reaction
Considerations
Skin Tests
Allergy ID
Medication Education
2 mins
Macrolides
Mechanism of Action
Bacteriostatic
Bind to 23S rRNA of 50S Subunit
Inhibit Protein Synthesis by Blocking Translocation
Macrolides
Erythromycin
Azithromycin
Clarithromycin
Indications
Gram-Positive Cocci
Atypical Pneumonia
Chlamydia
Considerations
Resistance by Methylation of 23S rRNA Binding
2 mins
Macrolides Side Effects
Side Effects
Diarrhea
Prolonged QT Interval
P450 Inhibitor
Cholestatic Hepatitis
Skin Rash
Eosinophilia
3 mins
Tetracyclines Overview
End in "-cycline"
Mechanism of Action
Bacteriostatic
Indications
Infectious Diseases
Acne
Periodontal Disease
Nursing Considerations
Avoid Milk, Antacids, Iron
Sunlight Protection
1 min
Tetracyclines Side Effects
Side Effects
Superinfection
Clostridioides difficile
Discoloration of Teeth
Bone Deformities
Photosensitivity
Contraindications
Children Under 8
Pregnancy
1 min
Fluoroquinolones Toxicities
Diarrhea
Skin Rash
Headache
Tendon Rupture in Adults
Myalgias in Kids
Damage to Cartilage
Teratogen
QT Prolongation
1 min
Sulfonamides
Mechanism of Action
Bacteriostatic
Indications
Urinary Tract Infection
Side Effects
Crystalluria
Photosensitivity
Hemolytic Anemia
Kernicterus
Rash
Considerations
Sulfa Allergy
Encourage Fluids
2 mins
Sulfonamides Side Effects
Side Effects
Hypersensitivity
Nephrotoxicity
Photosensitivity
Kernicterus in Infants
Displaces Warfarin from Albumin
Considerations
Hemolysis with G6PD Deficiency
3 mins
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