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Derives from Germinal Center
Occurs in adults
BCL 2 overexpression
BCL 2 inhibits apoptosis
Bone marrow involvement
Chronic Myelogenous Leukemia (CML)
Age 30 to 90 Years
Low Alkaline Phosphatase (ALK-P)
Blast Crisis can Accelerate and Transform to AML or ALL
Melanoma Mechanism and Characteristics
Associated with Sunlight Exposure
Mutation in B-RAF kinase
Large Number of Moles
Fair-Skinned people at higher risk
Radial Growth Phase
Vertical Growth Phase
Depth of tumor correlates with risk of metastasis
Adolescents or young adults
C-myc gene moves next to heavy chain Ig gene
Starry sky appearance
Sheets of lymphocytes with interspersed macrophages
Jaw lesion in endemic (African) form
Pelvis or abdomen in non endemic form (American form)
Associated with EBV
Wilms' Tumor (Nephroblastoma)
Malignant Renal Tumor
Do Not Palpate Abdomen
Children Under 5 Years Old
MEN 1 (Multiple Endocrine Neoplasia)
Menin Mutation (Tumor Suppression Gene)
Signs and Symptoms
Pancreatic Endocrine Tumors
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