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Beta 3 Receptor
Skeletal muscle thermogenesis increase
Gs Protein Class
Atypical Antipsychotic Names
These are all second generation antipsychotics
Varied effects on 5-HT2 (antagonism), dopamine, and α- and H1-receptors
Aripiprazole (Abilify) - D2 partial agonist
Asenapine, Clozapine, Quetiapine, Olanzapine
-pine associated with metabolic syndrome (Weight gain, Diabetes, Hyperlipidemia, tracking fasting glucose and lipid profile)
Clozapine and olanzapine carry the greatest risk of metabolic syndrome side effects
U. Olanzapine can be used for acute mania and anorexia
Olanzapine has affinity for muscarinic receptor
Most common side effects of olanzapine are sedation and weight gain
Most common side effects are metabolic syndrome and sedation (histamine)
Methcillin not used anymore do to several side effects
Same side effects as penicillin
Resistance occurs via altered PBPs
Inhibit protein synthesis by binding to 50S subunit and preventing formation of the initiation complex
Indications: Gram ⊕ species including MRSA and VRE
Bone marrow suppression (especially thrombocytopenia)
Peripheral neuropathy (optic most common but also glove and stocking peripheral nephropathy)
Serotonin syndrome due to MAOI activity
Point mutation of ribosomal RNA
Binds to the 23s portion
MOA: Similar to sulfonamides, but structurally distinct agent (Inhibit dihydropteroate synthase)
Leprosy (lepromatous and tuberculoid)
Pneumocystis jirovecii prophylaxis
Dermatitis herpetiformis (celiac disease)
Hemolysis if G6PD deficient
Fever, rash and methemogloinemia
MOA: Lipopeptide that disrupts cell membrane of gram ⊕ cocci; Bactericidal
S aureus skin infections (especially MRSA), bacteremia, endocarditis, VRE
Not used for pneumonia (avidly binds to and is inactivated by surfactant)
Depolarizes cellular membrane by creating transmembrane channels
Pyrazinamide is a prodrug that is converted to the active compound pyrazinoic acid
Works best at acidic pH (eg, in host phagolysosomes)
Indications: Mycobacterium tuberculosis
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