Umang Shared "Oklahoma St Univ COM - Genitourinary (2021)" - 27 Picmonics
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Oklahoma St Univ COM - Genitourinary (2021)
Loop of Henle
- Characteristics
- Descending Limb
- Water Follows Na+
- Medullary Hypertonicity
- Increased Water Reabsorption
- Vasa Recta
- Na+ Reabsorbed Via Active Transport
- Ascending Limb
- Reabsorbs Na+, K+, Cl-
- Decreased Concentration of Filtrate
- Impermeable to Water
- Distal Tubule
2 mins
Angiotensin II Synthesis
- Juxtaglomerular Apparatus
- Juxtaglomerular Cells
- Mesangial Cells
- Macula Densa
- Distal Tubule
- KEY MEDIATORS
- Angiotensinogen
- Secreted from Liver
- Renin
- Secreted from Juxtaglomerular Cells
- Catalyzes Angiotensinogen to Angiotensin I
- Angiotensin Converting Enzyme (ACE)
- Pulmonary Capillaries
- Catalyzes Angiotensin I to Angiotensin II
3 mins
Angiotensin II Effects
- Effects On Vasculature
- Increases Vascular Smooth Muscle Contraction
- Increases Blood Pressure
- Effects on Kidney
- Efferent Arteriole Vasoconstriction
- Increases GFR
- Proximal Tubule
- Sodium and Water Reabsorption
- Adrenal Cortex
- Increases Aldosterone Secretion
- Effects on CNS
- Stimulates Posterior Pituitary Gland to Secrete Vasopressin (ADH)
- Stimulates Thirst in Hypothalamus
2 mins
Casts in Urine (Differential Diagnosis)
- Characteristics
- RBC Casts
- Glomerular Disease
- WBC Casts
- Acute Interstitial Nephritis
- Acute Pyelonephritis
- Fatty Casts
- Maltese Cross Sign
- Nephrotic Syndrome
- Granular Muddy Brown Casts
- Acute Tubular Necrosis (ATN)
- Waxy Casts
- End Stage Renal Disease (ESRD) (Chronic Renal Failure)
- Hyaline Casts
- Non-Specific
2 mins
Membranous Glomerulonephritis
- Characteristics
- Nephrotic
- Diagnosis
- LM Thickening of Capillary and Glomerular Basement Membrane (GBM)
- EM Spike and Dome Appearance with Subepithelial Deposits
- IF Granular
- Primary
- Phospholipase A2 Receptor Autoantibodies
- Secondary
- NSAIDS
- Gold
- Solid Tumors
- Hepatitis B Virus (HBV)
- Lupus
3 mins
Focal Segmental Glomerulosclerosis
- Most Common Cause of Nephrotic Syndrome in Hispanic People and African Americans
- Associated with Sickle Cell Disease and HIV
- Associated Interferon Therapy and Heroin Abuse
- Histopathology
- LM Segmental Sclerosis and Hyalinosis
- EM Focal Damage of Visceral Epithelial Cells
- IF Negative
- Signs & Symptoms
- Microscopic Hematuria
- Nonselective Proteinuria
- Considerations
- Poor Prognosis
2 mins
Post Streptococcal Glomerulonephritis
- Pathophysiology
- Nephritic
- Children
- Signs and Symptoms
- Edema
- Cola Colored Urine
- Follows Group A Streptococcal pharyngitis or Skin Infection
- Diagnosis
- Neutrophils
- Immunofluorescence (IF) Granular
- Lumpy Bumpy Appearance on Immunofluorescence (IF)
- Subepithelial Immune Complex Humps
2 mins
Alport Syndrome
- Pathophysiology
- Nephritic
- X-linked
- Mutation in Type IV Collagen
- Diagnosis
- Split Basement Membrane
- Basket Weave Appearance
- Signs and Symptoms
- Ocular Disorders
- Deafness
2 mins
Hyperkalemia
- Assessment
- > 5.0 mEq/L K+
- Abdominal Cramps
- Muscle Weakness
- Diarrhea
- Arrhythmia
- Tall, Peaked T Waves
- Interventions
- IV Calcium
- Infusion of Glucose and Insulin
- Loop or Thiazide Diuretics
- Kayexalate
- Dialysis
- Prevention Education
2 mins
Hypercalcemia
- Assessment
- > 10.5 mg/dL Ca2+
- Pathologic Fractures
- Lethargy
- Hypercoagulation
- Constipation
- ECG Changes
- QT Shortening
- Interventions
- No Calcium Intake
- Chelating Drugs
- Calcitonin
- Bisphosphonates
- Loop Diuretics instead of Thiazide Diuretics
- Considerations
- Increased Risk for Renal Calculi
- Increase Fluids
3 mins
Hypermagnesemia
- Assessment
- Flushing
- Lethargy
- Muscle Weakness
- Decreased Deep Tendon Reflexes (DTRs)
- Decreased Respirations
- Bradycardia
- Hypotension
- Interventions
- Dialysis
- IV Calcium Gluconate
- Diuretics
- Avoid Antacids and Laxatives containing Mg2+
2 mins
Normal Gap Metabolic Acidosis
- HARD-ASS
- Hyperalimentation
- Addison's Disease
- Renal Tubular Acidosis
- Diarrhea
- Acetazolamide
- Spironolactone
- Saline Infusion
2 mins
Acetazolamide
- Indications
- Glaucoma
- Altitude Sickness
- Pseudotumor Cerebri
- CHF
- Metabolic Alkalosis
- Mechanism of Action
- Carbonic Anhydrase Inhibitor
- Sodium Bicarbonate (NaHCO3) Diuresis
- Side Effects
- Metabolic Acidosis
- Paresthesias
1 min
Loop Diuretics
- Mechanism of Action
- Thick Ascending Limb of Loop of Henle
- Inhibits Na+-K+-2Cl- Symporter
- Sulfa Drug
- Drug Names
- Furosemide
- Lasix
- Side Effects
- Gout
- Ototoxicity
- Hypocalcemia
- Hypokalemia
4 mins
K+ Sparing Diuretics
- Indications
- CHF and Hypertension
- Hypokalemia
- Hyperaldosteronism
- Mechanism of Action
- Collecting Tubule
- Spironolactone
- Competitive Aldosterone Receptor Antagonist
- Amiloride and Triamterene
- Block Na+ Channels
- Side Effects
- Hyperkalemia
- Gynecomastia
2 mins
ACE Inhibitors
- -Pril Suffix
- Indications
- Hypertension
- CHF
- Diabetic Nephropathy
- Mechanism of Action
- Inhibits ACE
- Decreases GFR
- Inhibits Constriction of Efferent Arteriole
- Side Effect
- Increased Bradykinin
- Cough
1 min
Renal Calculi Assessment
- Cause/Mechanism
- Hypercalcemia (Most Commonly)
- Signs and Symptoms
- Flank Pain
- Radiates Toward Bladder
- Renal Colic
- Urinary Tract Infection
- Urinary Retention
- Hematuria
- Considerations
- Stone Recurrence
2 mins
Proteus Mirabilis
- Characteristics
- Gram-Negative
- Bacillus
- Oxidase Negative
- Urease-Positive
- Swarming Motility
- Non-lactose Fermenting
- Symptoms
- Urinary Tract Infection
- Struvite Crystals
- Staghorn Kidney Stones
2 mins
Fluoroquinolones Antibiotics
- -floxacin
- Mechanism of Action
- Inhibits Topoisomerase II & IV
- Bactericidal
- Indications
- Gram-negative Rods
- Pneumonia
- Gastrointestinal Infections
- Urinary Tract Infection
- Genital Infections
- Drugs
- Levofloxacin
- Ciprofloxacin
- Has Pseudomonas Coverage
- Considerations
- Avoid Polyvalent Cations
3 mins
Fluoroquinolones Toxicities
- Diarrhea
- Skin Rash
- Headache
- Tendon Rupture in Adults
- Myalgias in Kids
- Damage to Cartilage
- Teratogen
- QT Prolongation
1 min
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