Daniel Shared "Neuro Pharm" - 48 Picmonics

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Neuro Pharm

Fusion Inhibitors
Indications
HIV
Drugs
Maraviroc
Binds CCR-5 on T Cells
Blocks Interaction with gp120
Enfuvirtide
Binds gp41
Inhibits Viral Entry
Side Effects
Skin Reactions at Injection Sites (Enfuvirtide)
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2 mins
NRTIs (Nucleoside Reverse Transcriptase Inhibitors)
Indications
HIV
Pregnancy and Prophylaxis given ZDV
Mechanism
Inhibit Nucleotide Binding to Reverse Transcriptase
Chain Termination
Require Phosphorylation
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1 min
NRTI Toxicity
Bone Marrow Suppression
Reverse with G-CSF and Erythropoietin
Rash
Neuropathy
Anemia
Pancreatitis
Lactic Acidosis
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1 min
NNRTIs (Non-nucleoside Reverse Transcriptase Inhibitors)
Indications
HIV
Mechanism
Do Not Require Intracellular Metabolism
Inhibits Reverse Transcriptase
Side Effects
Rash
Hepatotoxicity
Vivid Dreams and CNS Symptoms
Contraindication
Pregnancy
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2 mins
Protease Inhibitors
End in "-navir"
Indications
HIV/AIDS
Hepatitis C
Mechanism
Inhibit Protease
Unable to Cleave Proteins
Inhibits Maturation of New Virus
Side Effects
GI Distress
Nephropathy
Lipodystrophy
Hyperglycemia
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3 mins
Integrase Inhibitors
-gravir Suffix
Indications
HIV
Mechanism
Blocks Insertion of Viral Genome
Inhibit Actions of Integrase
Side Effects
Hypercholesterolemia
Increased LFT's
Insomnia
Increased Creatine Kinase (CK)
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1 min
HIV Prophylaxis Medications
CD4+ < 200
TMP-SMX
Pneumocystis Pneumonia
CD4+ < 100 Susceptible to Toxoplasma Gondii
CD4+ < 50
Mycobacterium Avium and Intracellulare
Azithromycin If Delayed Therapy
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2 mins
Lithium
Indications
Bipolar Disorder
Mechanism of Action
Mood Stabilizer
Unknown Mechanism
Side Effects
Nephrogenic Diabetes Insipidus
Hypothyroidism
Movement (Tremor)
Heart Block
Contraindication
Pregnancy (Ebstein's Anomaly)
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1 min
Ethosuximide
Indications
First Line Absence Seizure Treatment
Mechanism of Action
Blocks Thalamic T-Type Ca2+ Channels
Side Effects
Stevens-Johnson Syndrome
Fatigue
Diarrhea
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32 secs
Valproic Acid
Indications
First Line Tonic-Clonic Seizure Treatment
Bipolar Disorder
Migraine Prophylaxis
Mechanism of Action
Increases GABA Concentration
Blocks Voltage-Gated Na+ Channels
Side Effect
GI Distress
Contraindication
Contraindicated in Pregnancy
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1 min
Carbamazepine
Indications
First-line Seizure Medication
First Line for Trigeminal Neuralgia
Mechanism of Action
Stabilizes Inactive State of Na+ Channels
Side Effects
Stevens-Johnson Syndrome
Induce Cytochrome P450
Teratogen
Hepatotoxicity
Blood Dyscrasias
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2 mins
Phenytoin
Indications
Status Epilepticus
Tonic-Clonic Seizures
Mechanism of Action
Blocks Na+ Channel Activation
Inhibition of Glutamate Release
Class IB Antiarrhythmic
Side Effects
Teratogenic
Macrocytic Megaloblastic Anemia
Induce Cytochrome P450
Drug-induced Lupus
Neuropathy
Hirsutism
Gingival Hyperplasia
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1 min
Lamotrigine
Indications
Seizure Treatment
Bipolar Disorder
Mechanism of Action
Blocks Voltage-Gated Na+ Channels
Side Effect
Stevens-Johnson Syndrome
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1 min
Topiramate
Indications
Seizure Treatment
Migraine Prophylaxis
Mechanism of Action
Increase GABA Action
Blocks Voltage-Gated Na+ Channels
Side Effects
Kidney Stones
Weight Loss
Sedation
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1 min
Antipsychotics Overview
Indications
Schizophrenia
Tourette's Syndrome
Mechanism of Action
Lipid-Soluble
Block Dopamine Receptors
Side Effects
Galactorrhea
Tardive Dyskinesia
Anticholinergic
Alpha1 Antagonist
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2 mins
Low Potency Antipsychotic Drugs
Drugs
Chlorpromazine
Corneal Deposits
Thioridazine
Retinal Deposits
Shared Side Effects
Alpha1 Antagonist Effects
Anticholinergic Effects
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51 secs
High Potency Antipsychotic Drugs
High Potency Drugs
Fluphenazine
Trifluoperazine
Haloperidol
Side Effects
Extrapyramidal Symptoms
Short Term
Dystonia
Torticollis
Long Term
Tardive Dyskinesia
Parkinson's-like Symptoms
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1 min
Atypical Antipsychotics
Indications
Schizophrenia
Mechanism of Action
Unknown Mechanism
Side Effects
Seizures
Prolonged QT Interval
Agranulocytosis
Weight Gain
Fewer Extrapyramidal Side Effects
Fewer Anticholinergic Side Effects
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2 mins
Neuroleptic Malignant Syndrome
FEVER Acronym
Fever
Encephalopathy
Vital Signs Unstable
Elevated Enzymes
Rigidity of muscles
Reversal Agent
D2 Agonists
Bromocriptine
Dantrolene
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2 mins
Selective Serotonin Reuptake Inhibitor (SSRI) Overview
Indications
Depression
Anxiety
Mechanism of Action
Selective Serotonin Reuptake Inhibitors
Drugs
Paroxetine
Sertraline
Escitalopram
Fluoxetine
Side Effects
Sexual Dysfunction
Serotonin Syndrome
Treat with Cyproheptadine
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2 mins

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