Mike Shared "Chap 2 Anti-infective Agents" - 86 Picmonics
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Chap 2 Anti-infective Agents
Pinworm (Enterobius Vermicularis)
- Pathophysiology
- Nematode (Roundworm)
- Ingestion of Eggs
- Intestinal Infection
- Anal Pruritus
- Diagnosis
- Scotch Tape Test
- Treatment
- Albendazole
- Pyrantel Pamoate
2 mins
Loa Loa
- Pathophysiology
- Nematode (Roundworm)
- Fly Bite
- Calabar Swellings in Skin
- Conjunctiva
- Treatment
- Diethylcarbamazine (DEC)
- Albendazole
1 min
Onchocerca Volvulus
- Pathophysiology
- Nematode (Roundworm)
- Female Blackfly Bite
- Hyperpigmented Skin
- River Blindness
- Treatment
- Ivermectin
1 min
Strongyloides Stercoralis
- Pathophysiology
- Nematode (Roundworm)
- Larvae in Soil Penetrate Skin
- Uncomplicated Disease
- GI Distress
- Loffler's Syndrome
- Dermatitis
- Disseminated Disease
- Immunosuppressed
- Treatment
- Ivermectin
- Albendazole
2 mins
Clonorchis Sinensis
- Pathophysiology
- Trematode (Fluke)
- Undercooked Fish
- Biliary Tract Inflammation
- Pigmented Gallstones
- Associated with Cholangiocarcinoma
- Treatment
- Praziquantel
1 min
Schistosoma
- Pathophysiology
- Trematode (Fluke)
- Snail-infested Water
- Intense Immune Response
- Intestinal Disease
- Hepatosplenic Granuloma
- Squamous Cell Cancer of the Bladder
- Diagnosis
- Parasitic Antigens via ELISA
- Treatment
- Praziquantel
2 mins
Diphyllobothrium Latum
- Pathophysiology
- Cestode (Tapeworm)
- Ingestion of Larvae from Raw Fish
- Competes for Vitamin B12
- Megaloblastic Anemia
- Treatment
- Praziquantel
1 min
Echinococcus Granulosus
- Pathophysiology
- Cestode (Tapeworm)
- Ingestion of Eggs from Dog Feces
- Hydatid Cysts in Liver
- Fibrosis and Necrosis
- Anaphylaxis if Antigens Released
- Treatment
- Albendazole
- Surgical Removal
1 min
Taenia Solium
- Pathophysiology
- Cestode (Tapeworm)
- Taeniasis
- Ingestion of Larvae in Undercooked Pork
- Asymptomatic, in Bowels
- Cysticercosis
- Ingestion of Cestode Eggs
- Skin, CNS and Muscles
- Treatment
- Albendazole
- Praziquantel
1 min
Antibiotics Overview
- Cell Wall Inhibitors
- Cell Wall Inhibitors
- Penicillins
- Cephalosporins
- Monobactams
- Glycopeptides
- Carbapenems (Imipenem & Meropenem)
- Beta-Lactamase Inhibitors
- Protein Synthesis Inhibitors
- Protein Synthesis Inhibitors
- Aminoglycosides
- Macrolides
- Clindamycin
- Tetracyclines
- Linezolid
- Chloramphenicol
- Other
- Fluoroquinolones
- Sulfonamides
4 mins
Aminoglycosides
- Drug Names
- Gentamicin
- Neomycin for Bowel Surgery Prep
- Amikacin
- Tobramycin
- Streptomycin
- Mechanism of Action
- Bactericidal
- Inhibit Formation of Initiation Complex
- Cause Misreading of mRNA
- Require O2 for Uptake
- Resistance
- Resistance by Transferase Enzymes
- Acetylation
- Phosphorylation
- Adenylation
- Indications
- Gram-Negative Rod Infections
- Synergistic with B-Lactam Antibiotics
- Side Effects
- Nephrotoxicity Especially When Used with Cephalosporins
- Ototoxicity Especially When Used with Loop Diuretics
- Teratogen
5 mins
Cephalosporins Overview
- Mechanism of Action
- Beta lactam drug
- Inhibits cell wall synthesis
- Bactericidal
- Side Effects
- Hypersensitivity reactions
- Vitamin K Deficiency
- Disulfiram like reaction with Alcohol
- Increased Nephrotoxicity of Aminoglycosides
1 min
1st Generation Cephalosporin
- Drug Names
- Cefazolin
- Cephalexin
- Indications (PEcK Mnemonic)
- Proteus mirabilis
- E. coli
- Klebsiella
- Gram-Positive Cocci
1 min
2nd Generation Cephalosporin
- Drug Names
- Cefoxitin
- Cefaclor
- Cefuroxime
- Indications (PEcK HENS Mnemonic)
- Proteus mirabilis
- E. coli
- Klebsiella
- Gram-Positive Cocci
- Haemophilus influenzae
- Enterobacter
- Neisseria
- Serratia marcescens
2 mins
3rd Generation Cephalosporin
- Drug Names
- Cefotaxime
- Ceftriaxone
- Cefdinir
- Ceftazidime
- Pseudomonas
- Indications
- Serious Gram-Negative Bacteria Resistant to Other Beta-Lactams
1 min
4th Generation Cephalosporin
- Drug Name
- Cefepime
- Indications
- Increased Activity Against Gram-Positive Infections and Pseudomonas
29 secs
5th Generation Cephalosporin
- Mechanism
- Beta-Lactam
- Indications
- Resistant Bacteria
- Broad Spectrum Gram-Positive and Gram-Negative
- Drugs
- Ceftobiprole
- Has Pseudomonas Coverage
- Ceftaroline
- No Pseudomonas Coverage
1 min
Imipenem
- Mechanism
- Resistant to Beta-Lactamases
- Broad Spectrum
- Indications
- Anaerobes
- Gram-Negative Rods
- Gram-Positive Cocci
- Must Administer with Cilastatin
- Cilastatin is Inhibitor of Renal Dehydropeptidase I
- Side Effects
- Diarrhea
- Skin Rash
- Seizures
- Considerations
- Meropenem
- Stable to Dehydropeptidase I
- Reduced Risk of Seizures (Non-Seizure Causing)
2 mins
Aztreonam
- MECHANISM
- Monobactam
- Resistant to Beta-Lactamases
- Binds to Penicillin-Binding Protein (PBP)
- Inhibit Cell Wall Synthesis
- Bactericidal
- INDICATIONS
- No Activity on Gram-Positives or Anaerobes
- Gram-Negative Rods
- Cystic Fibrosis
- CONSIDERATIONS
- Non Allergenic to Penicillin
- Synergistic with Aminoglycosides
- SIDE EFFECTS
- GI Upset
- Pain at Injection Site
2 mins
Macrolides
- Mechanism of Action
- Bacteriostatic
- Bind to 23S rRNA of 50S Subunit
- Inhibit Protein Synthesis by Blocking Translocation
- Macrolides
- Erythromycin
- Azithromycin
- Clarithromycin
- Indications
- Gram-Positive Cocci
- Atypical Pneumonia
- Chlamydia
- Considerations
- Resistance by Methylation of 23S rRNA Binding
2 mins
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