Matthew Shared "Neuro Pharm" - 34 Picmonics
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Neuro Pharm
Ethosuximide
- Indications
- First Line Absence Seizure Treatment
- Mechanism of Action
- Blocks Thalamic T-Type Ca2+ Channels
- Side Effects
- Stevens-Johnson Syndrome
- Fatigue
- Diarrhea
32 secs
Phenytoin
- Indications
- Status Epilepticus
- Tonic-Clonic Seizures
- Mechanism of Action
- Blocks Na+ Channel Activation
- Inhibition of Glutamate Release
- Class IB Antiarrhythmic
- Side Effects
- Teratogenic
- Macrocytic Megaloblastic Anemia
- Induce Cytochrome P450
- Drug-induced Lupus
- Neuropathy
- Hirsutism
- Gingival Hyperplasia
1 min
Carbamazepine
- Indications
- First-line Seizure Medication
- First Line for Trigeminal Neuralgia
- Mechanism of Action
- Stabilizes Inactive State of Na+ Channels
- Side Effects
- Stevens-Johnson Syndrome
- Induce Cytochrome P450
- Teratogen
- Hepatotoxicity
- Blood Dyscrasias
2 mins
Valproic Acid
- Indications
- First Line Tonic-Clonic Seizure Treatment
- Bipolar Disorder
- Migraine Prophylaxis
- Mechanism of Action
- Increases GABA Concentration
- Blocks Voltage-Gated Na+ Channels
- Side Effect
- GI Distress
- Contraindication
- Contraindicated in Pregnancy
1 min
Valproic Acid (Valproate) Side Effects
- V-A-L-P-R-O-A-T-E
- Vomiting
- Alopecia
- Liver Toxicity
- Pancreatitis/Pancytopenia
- Retain Fat (Weight Gain)
- Oedema (Edema)
- Appetite Increase
- Tremor
- Enzyme Inhibitor (P450)
2 mins
Gabapentin
- Primary Indication
- Seizure Treatment
- Secondary Indications
- Peripheral Neuropathy
- Postherpetic Neuralgia
- Bipolar Disorder
- Migraine Prophylaxis
- Characteristics
- Inhibits Voltage-Gated Ca2+ channels
- Designed as a GABA Analog
- Side Effects
- Ataxia
- Sedation
2 mins
Topiramate
- Indications
- Seizure Treatment
- Migraine Prophylaxis
- Mechanism of Action
- Increase GABA Action
- Blocks Voltage-Gated Na+ Channels
- Side Effects
- Kidney Stones
- Weight Loss
- Sedation
1 min
Lamotrigine
- Indications
- Seizure Treatment
- Bipolar Disorder
- Mechanism of Action
- Blocks Voltage-Gated Na+ Channels
- Side Effect
- Stevens-Johnson Syndrome
1 min
Vigabatrin, Levetiracetam, Tiagabine
- All increase GABA
- Vigabatrin
- Increases GABA Concentration: inhibiting GABA transaminase
- Permanent blindess (vission loss= blind bat)
- Levetiracetam
- Tonic-clonic
- Module GABA ans glutamate realse
- Side Fx: fatigue, drowsiness, headache, neuropsych symptoms
- Tigabine
- inhibit GABA reuptake (increase GABA)
Barbiturates
- Barb- Drug Names
- Indications
- Seizure Treatment
- Anesthesia Induction
- Mechanism of Action
- Increased Duration of Cl- Channel Opening
- Decrease Neuron Firing
- Side Effects
- Sedation
- Cardiovascular and Respiratory Depression
- CNS Depression
- P450 inducer
2 mins
Benzodiazepines Overview
- Indications
- First Line for Status Epilepticus
- Anesthesia Induction
- Anxiety
- Eclampsia
- Detoxification
- Mechanism of Action
- '-zepam' and '-zolam" Suffix
- Increase Frequency of Cl- Channel Opening
- Side Effects
- Decrease REM Sleep
- CNS Depression
- Dependence
- Antidote
- Flumazenil for Overdose
2 mins
Nonbenzodiazepine Hypnotics
- Indications
- Insomnia
- Mechanism of Action
- Short Half-Life
- Acts on BZ1 GABA receptor
- Less dependence
- Drugs
- Zolpidem (Ambien)
- Side Effects
- Ataxia, confusion
- Antidote
- Flumazenil for Overdose
1 min
Methylergonovine (Methergine) and Ergotamine (Ergot Alkaloids)
- Mechanism
- Smooth Muscle Contraction
- Vasoconstriction
- Indications
- Migraine
- Postpartum Hemorrhage
- Side Effects
- Nausea and Vomiting
- Severe Hypertension
- Tachycardia
- Considerations
- 2nd Line Agent
2 mins
Sumatriptan
- Mechanism of Action
- Short Half-Life
- 5-HT Agonist
- Inhibits Trigeminal Nerve Activation
- Induces Vasoconstriction
- Indications
- Migraine
- Cluster Headache
- Side Effects
- Increased Risk of Serotonin Syndrome
- Paresthesias
- Coronary Vasospasm
- Contraindication
- Prinzmetal's Angina
- Coronary Artery Disease (CAD)
3 mins
Parkinson's Disease Interventions
- Medications
- Levodopa/Carbidopa (Sinemet)
- Entacapone (Comtan)
- Selegiline (Eldepryl)
- Amantadine (Symmetrel)
- Bromocriptine (Parlodel)
- Benztropine (Cogentin)
- Considerations
- Allow Extra Time
- Ensure Patient Safety
- Surgery As Last Resort
2 mins
Levodopa/Carbidopa (Sinemet)
- Indications
- Parkinson's Disease
- Mechanism of Action
- Increase Dopamine in Brain
- Cross blood-brain barrier
- Increase bioavailability
- Side Effects
- Arrhythmias
- Dyskinesia
1 min
Memantine
- Indications
- Alzheimer's Disease
- Mechanism of Action
- NMDA Receptor Antagonist
- Prevents Excitotoxicity
- Side Effects
- Confusion
- Hallucinations
1 min
Donepezil
- Indications
- Alzheimer's Disease
- Mechanism of Action
- Acetylcholinesterase Inhibitor
- Increased Acetylcholine
- Side Effects
- Nausea and Vomiting
- Dizziness
52 secs
Inhaled Anesthetics
- Mechanism of Action
- Unknown Mechanism
- Inhaled Anesthetic Drugs
- HEISMN Drug Name Acronym
- Side Effects
- Respiratory Depression
- Myocardial Depression
- Lower Metabolic Demand, Increased Cerebral Blood Flow
- Hepatotoxicity (Halothane)
- Nephrotoxicity (Methoxyflurane)
- Seizure (Enflurane)
- Malignant Hyperthermia
- Expansion of Trapped Gas
2 mins
IV Anesthetics
- Barbiturates
- Benzodiazepines
- Respiratory Depression
- Hypotension
- Ketamine
- NMDA Receptor Antagonist
- Hallucinations
- Opioids
- Propofol
- Potentiates GABA-A
2 mins
