Shawn Shared "ID Week 1" - 21 Picmonics
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ID Week 1
5th Generation Cephalosporin
- Mechanism
- Beta-Lactam
- Indications
- Resistant Bacteria
- Broad Spectrum Gram-Positive and Gram-Negative
- Drugs
- Ceftobiprole
- Has Pseudomonas Coverage
- Ceftaroline
- No Pseudomonas Coverage
1 min
Aminoglycosides
- Drug Names
- Gentamicin
- Neomycin for Bowel Surgery Prep
- Amikacin
- Tobramycin
- Streptomycin
- Mechanism of Action
- Bactericidal
- Inhibit Formation of Initiation Complex
- Cause Misreading of mRNA
- Require O2 for Uptake
- Resistance
- Resistance by Transferase Enzymes
- Acetylation
- Phosphorylation
- Adenylation
- Indications
- Gram-Negative Rod Infections
- Synergistic with B-Lactam Antibiotics
- Side Effects
- Nephrotoxicity Especially When Used with Cephalosporins
- Ototoxicity Especially When Used with Loop Diuretics
- Teratogen
5 mins
Aztreonam
- Monobactam
- Resistant to beta lactamases
- Binds to penicillin binding protein (PBP)
- Inhibit cell wall synthesis
- No Activity on Gram-Positives or Anaerobes
- Gram-Negative Rods
- Non allergenic to penicillin
- Synergistic with aminoglycosides
2 mins
Beta-Lactamase Inhibitors
- Considerations
- Often Combined with Penicillin Antibiotics
- Drug Names
- Clavulanic Acid
- Sulbactam
- Tazobactam
51 secs
Cephalosporins Overview
- Mechanism of Action
- Beta lactam drug
- Inhibits cell wall synthesis
- Bactericidal
- Side Effects
- Hypersensitivity reactions
- Vitamin K Deficiency
- Disulfiram like reaction with Alcohol
- Increased Nephrotoxicity of Aminoglycosides
1 min
Clindamycin
- Mechanism of Action
- Bacteriostatic
- Binds 50S Ribosomal Subunit
- Blocks Translocation
- Indications
- Anaerobic Infections above the Diaphragm
- Aspiration Pneumonia
- Lung Abscess
- Side Effects
- Can Cause Pseudomembranous Colitis
1 min
Corynebacterium diphtheriae
- Characteristics
- Gram-Positive
- Bacillus
- Exotoxin
- ADP Ribosylation of Elongation Factor 2
- Beta Prophage
- Lysogeny
- Tellurite Agar
- Chinese Letters
- Metachromatic Blue Red Granules
- Aniline Stains Deeply Methylene Blue
- Signs and Symptoms
- Pseudomembranous Pharyngitis
- Lymphadenopathy
- Myocarditis
- Polyneuritis
3 mins
Enterococci
- Characteristics
- Gram-Positive Cocci
- Catalase Negative
- 6.5% NaCl
- Grows in Bile
- Normal Colonic Flora
- Signs and Symptoms
- Urinary Tract Infection
- Subacute Endocarditis
- Penicillin Resistant
- VRE (Vancomycin Resistant Enterococci)
2 mins
Imipenem
- Mechanism
- Resistant to Beta-Lactamases
- Broad Spectrum
- Indications
- Anaerobes
- Gram-Negative Rods
- Gram-Positive Cocci
- Must Administer with Cilastatin
- Cilastatin is Inhibitor of Renal Dehydropeptidase I
- Side Effects
- Diarrhea
- Skin Rash
- Seizures
- Considerations
- Meropenem
- Stable to Dehydropeptidase I
- Reduced Risk of Seizures (Non-Seizure Causing)
2 mins
Legionella Characteristics
- Characteristics
- Bacillus
- Poor Gram Stain
- Charcoal Yeast with Iron and Cysteine
- Silver Stain
- Water Sources
- Smokers and Heavy Drinkers
- Detect Antigen in Urine
2 mins
Legionella Disease
- Signs and Symptoms
- High Fever
- Diarrhea
- Increased Liver Enzymes
- Hyponatremia
- Type IV Renal Tubular Acidosis
- Severe Atypical Pneumonia
- Pontiac Fever
- Treatment
- Fluoroquinolones
- Macrolides
2 mins
Penicillin
- Gram Positive
- Spirochetes
- Bind PBPs
- Block Transpeptidase Cross-linking of Cell Wall
- Activate Autolytic Enzymes
- Bactericidal
- Hypersensitivity Reactions
- Hemolytic Anemia
- Beta-lactamase Sensitive
2 mins
Rhinovirus
- Picornavirus
- Cause of Common Cold
- More than 100 Serologic Types
- Destroyed by Stomach Acid
32 secs
Staphylococcus aureus Characteristics
- Characteristics
- Gram-Positive
- Cocci
- Catalase-Positive
- Coagulase-Positive
- Beta-Hemolytic
- Protein A Virulence Factor
- Inhibits Phagocytosis
- MRSA
- Resistant to Beta Lactams Due to Altered Penicillin Binding Proteins (PBPs)
2 mins
Staphylococcus aureus Disease
- Skin Infections
- Impetigo
- Abscesses
- Exfoliative Toxin
- Scalded Skin Syndrome
- Toxic Shock Syndrome (TSST 1)
- Binds to MHC II and T Cell Receptor
- Food Poisoning
- Acute Bacterial Endocarditis
- Pneumonia
- Osteomyelitis
2 mins
Streptococcus Pneumoniae Characteristics
- Characteristics
- Gram-Positive
- Diplococci
- Lancet-Shaped
- Catalase-Negative
- Optochin-Sensitive
- Bile Soluble
- Alpha-Hemolytic
- Polysaccharide Capsule
- Positive Quellung Reaction
- IgA Protease
1 min
Streptococcus Pneumoniae Disease
- Signs and Symptoms
- Sickle Cell Anemia
- Sepsis in Patients with Splenectomy
- Rusty Sputum
- MOPS
- Meningitis
- Otitis Media
- Pneumonia
- Sinusitis
2 mins
Streptococcus Pyogenes Disease
- Pyogenic
- Pyogenic
- Pyogenic Pharyngitis
- Impetigo
- Cellulitis
- Toxigenic
- Toxic Shock-Like Syndrome
- Scarlet Fever
- Sandpaper Rash
- Strawberry Tongue
- Immunologic
- Immunologic
- Rheumatic Fever
- Antibodies to M Protein
- Acute Glomerulonephritis (Post Streptococcal Glomerulonephritis)
2 mins
Streptococcus pyogenes Characteristics
- Characteristics
- Group A Streptococci (GAS)
- Gram-Positive
- Cocci
- Beta-Hemolytic
- Catalase-Negative
- Bacitracin-Sensitive
- Hyaluronic Acid Capsule
- Streptolysin O
- DNase
- Streptokinase
- Exotoxin A
- Pyrrolidonyl Arylamidase (PYR) Positive
2 mins
Vancomycin Mechanism
- Bacteriostatic and Bactericidal
- Gram-Positive
- Inhibits Cell Wall Mucopeptide
- Binds to D-ala D-ala
- Resistance with Change to D-ala D-lac
- Staphylococcus aureus
- Orally for Clostridium difficile
- Enterococci
2 mins
