Adam Shared "Pancreatic Islet Tumors" - 3 Picmonics

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Pancreatic Islet Tumors

Glucagonoma
Tumor of pancreatic α cells
Overproduction of glucagon
Diabetes (hyperglycemia)
Declining weight
Depression
Anemia
Dermatitis (necrolytic migratory erythema), typically affects the groin mostly (but also face/extremities)
Blistering and scaling
DVT
Glossitis, cheilitis, blepharitis
MEN 1 Association
Treatment
Octreotide
Surgery
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Insulinoma
Tumor of pancreatic β cells
Overproduction of insulin
Hypoglycemia (tremor, confusion)
Increased C peptide production
10% of cases associated with MEN 1 syndrome
Whipple triad
Symptoms of hypoglycemia (lethargy, syncope, diplopia)
Low blood glucose
Resolution of symptoms after normalization of glucose levels
Treatment
Surgery
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Somatostatinoma
Tumor of pancreatic δ cells
Overproduction of somatostatin
Decreased secretion of secretin, cholecystokinin, glucagon, insulin, gastrin
Symptoms
Diabetes/glucose intolerance
Steatorrhea
Gallstones because somatostatin decreases CCK secretion (decreased gallbladder contraction)
Can be hyperglycemia or hypoglycemic
Achlorhydria (due to inhibition of gastrin)
Inhibiting GI motility
Treatment
Surgical resection
Somatostatin analogs (eg, octreotide) for symptom control
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