Janani Shared "Z Endo" - 47 Picmonics

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Z Endo

Gs protein receptors "cAMP" (FLAT CHAMP)
adenylate cyclase -> cAMP -> PKA
FSH
LH
ACTH
TSH
CRH
hCG
ADH (V2)
MSH
PTH
Calcitonin
GHRH
glucagon
H2
epinephrine
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cGMP Signaling Hormones (GOAT HAG)
GnRH
Oxytocin
ADH (V1-receptor)
TRH
Histamine (H1-receptor)
Angiotensin II
Gastrin
IP3
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Enzyme-linked Receptors
Receptor Guanylate Cyclase: ANP, BNP (membrane), Nitric Oxide (soluble)
Receptor Tyrosine Kinase (RTK): Growth Factors | RET gene encodes RTK
Tyrosine Kinase-associated Receptors
PIGGLET Mnemonic
PRL
Immunomodulators
GH
G-CSF & EPO
TPO
JAK-STAT
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glut transporter (DELETED)
GLUT-1
Placenta
RBCs
Cornea
Brain
Colon
Kidney
GLUT-2
Islets of Langerhans
Liver
small intestine
Glut-3
Brain, placenta
GLUT-5
Spermatocytes, GI tract
GLUT-4
adipose tissue, striated muscle
Kidney
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Regulation of phosphofructokinase-1
Fasting State
Increased Glucagon (cAMP)
Phosphorylate & activate Fructose Bisphosphatase-2 (FBPase2)
gluconeogenesis
Fed State
Increased Insulin (decreased cAMP)
Phosphofructokinase-2
Glycolysis
F-1,6-Bpase is upregulated by citrate, ATP, acetyl coA
PFK-2 activates fructose 2,6 BP, which activates PFK1
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dopamine agonists
Ergots
Bromocriptine
non ergots
pramipexole
ropinirole
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17 Alpha Hydroxylase Deficiency
Decreased Cortisol
Decreased Sex Hormones
Increased Mineralocorticoids (DOC)
Hypertension
Hypokalemia
XY Externally Phenotypic Female
No Internal Reproductive Structures Due to Mullerian Inhibitory Factor
XX Externally Phenotypic Female
Sexual Infantilism
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2 mins
21 Hydroxylase Deficiency
Pathophysiology
Decreased Cortisol
Increased 17 Hydroxyprogesterone
Decreased Aldosterone
Signs and Symptoms
Hypotension
Increased Renin
Hyperkalemia
Female Pseudohermaphroditism
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2 mins
11 Beta-Hydroxylase Deficiency
Pathophysiology
Decreased Cortisol
Decreased Aldosterone
Increased Sex Hormones
Increased 11 Deoxycorticosterone (11 DOC)
Signs and Symptoms
Hypertension
Masculinization
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1 min
Sheehan's Syndrome
Postpartum Pituitary Gland Necrosis
Agalactorrhea
Amenorrhea
Secondary Hypothyroidism with Cold Intolerance
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1 min
Syndrome Of Inappropriate Antidiuretic Hormone (SIADH)
Pathophysiology
Hypersecretion of ADH
Increased Sensitivity to ADH
Signs & Symptoms
Serum Hypoosmolality
Coma and Seizure
Dilutional Hyponatremia
Cramps and Tremors
Euvolemia
Change in LOC
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2 mins
Syndrome of Inappropriate Antidiuretic Hormone (SIADH) Pharmacologic Interventions
Diuretics
Hypertonic IV Fluids
Demeclocycline
Tolvaptan and Conivaptan
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1 min
Hypothyroidism Assessment
Assessment
Weight Gain - Edema
Lethargy
Cold Intolerance
Bradycardia
Hypertension
Brittle Nails and Dry Skin
Constipation
Goiter
Prolonged Menses
Slowed Thinking
Diagnostic Tests
Decreased Free T4
Increased TSH
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Hypothyroidism Intervention
Medications
Levothyroxine (Synthroid)
Liothyronine (Cytomel)
Complication
Myxedema Coma
Nursing Considerations
Lifelong Replacement Hormone
Monitor Vital Signs
Fluids and Fiber
Low Calorie, Low Fat Diet
Medication Education
No Switching Brands
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Congenital Hypothyroidism (Cretinism)
Cause
Thryoid dysgenesis
The 6 P's of congenital hypothyroidism
6 P's
Poor brain development
Pot-bellied
Pale
Puffy face
Protruding Umbilicus
Protuberant Tongue
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Hyperthyroidism Assessment
Assessment
Heat Intolerance
Exophthalmos
Warm, Moist Skin and Silky Hair
Tremors
Goiter
Diarrhea
Weight Loss
Tachycardia
Hypertension
Amenorrhea
Diagnosis
Decreased TSH with Elevated Free T4
Radioactive Iodine Uptake (RAIU)
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2 mins
Hyperthyroidism Interventions
Drug Therapy
Propylthiouracil (PTU)
Methimazole (Tapazole)
Iodine
Beta Blockers
Other Therapies
Radioiodine Ablation
Thyroidectomy
Complications
Thyrotoxicosis
Post-Surgery Hypocalcemia
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2 mins
Graves' Disease Characteristics
Women 20-40 years old
Pathophysiology
Anti-TSH Receptor Antibodies
Symptoms
Ophthalmopathy
Exophthalmos
Hyperthyroidism
Goiter
Pretibial Myxedema
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1 min
Graves' Disease Labs and Treatment
Labs
Decreased TSH
Increased T3
Increased T4
Radioactive Iodine Uptake (RAIU)
Treatment
Beta blocker
Methimazole
Radioiodine Ablation
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1 min
Hashimoto's Thyroiditis
Symptoms
Hypothyroidism with Bouts of Hyperthyroidism
Enlarged, Nontender Thyroid
Mechanism
Autoimmune
Anti-Thyroid Peroxidase (TPO)
Anti-Thyroglobulin
Lab Findings
Hurthle Cells
Lymphoid Follicles
Associations
HLA-DR5 and HLA-DR3
Increased Risk Of Non-Hodgkin Lymphoma
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2 mins

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