Ahmed Emad Shared "STEP 1 Challenges" - 53 Picmonics
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STEP 1 Challenges
Tamoxifen
- Mechanism of Action
- Selective Estrogen Receptor Modulator (SERM)
- Antagonist on Breast Tissue
- Indications
- ER-positive Breast Cancer
- Side Effects
- Decreased Risk of Osteoporosis
- Increased Risk of Endometrial Cancer
- Increased Risk of Venous Thromboembolism (VTE)
1 min
Erlotinib
- Mechanism of Action
- Inhibits EGFR Tyrosine Kinase
- Inhibits Progression of G1 to S Phase
- Indications
- Non-small Cell Lung Cancer (NSCLC)
- Pancreatic Cancer
- Side Effects
- Rash
- Diarrhea
- Considerations
- Avoid Grapefruit Juice
1 min
Brachial Plexus Roots
- C5 through T1
- Long Thoracic Nerve
- Dorsal Scapular Nerve
43 secs
Brachial Plexus Trunks
- Superior Trunk
- Suprascapular Nerve
- Middle Trunk
- Inferior Trunk
1 min
Busulfan
- Indications
- CML
- Bone Marrow Ablation
- Mechanism
- Cross-Links DNA
- Side Effects
- Myelosuppression
- Pulmonary Fibrosis
- Hyperpigmentation
55 secs
Bleomycin
- Indications
- Testicular Cancer
- Hodgkin's Lymphoma
- Mechanism of Action
- Induces Free Radical Formation
- Breaks in DNA Strands
- Side Effects
- Pulmonary Fibrosis
- Skin Changes
- Mucositis
1 min
Prazosin (Minipress)
- -osin suffix
- Mechanisms
- Selective Alpha-1 Receptor Blocker
- Indications
- Hypertension
- Benign Prostatic Hyperplasia (BPH)
- Nightmares
- Side Effects
- Orthostatic Hypotension
- Tachycardia
- Priapism / Inhibition of Ejaculation
- Nasal Congestion
- Considerations
- First Dose Effect
- Administer at Bedtime
2 mins
Donepezil
- Indications
- Alzheimer's Disease
- Mechanism of Action
- Acetylcholinesterase Inhibitor
- Increased Acetylcholine
- Side Effects
- Nausea and Vomiting
- Dizziness
52 secs
Ipatropium, tiotropium, atropine, and aclidinum bromide for asthma
- Drugs
- Ipratropium
- Tiotropium
- Atropine
- Aclidinum Bromide
- Functionally similar to tiotropium
- Less SE due to short half-life
- Mechanism of Action
- Blocks vagus nerve to decrease tone in bronchial smooth muscle
- Blocks reflex bronchoconstriction caused by inhaled irritants
- Indication
- COPD (1st line treatment)
- Status asthmaticus (with b2-agonist nebulizer)
- No role in chronic stable asthma
- Side Effects
- Antimuscarinics (SLUDGE)
- Acute-angle Glaucoma
- Bronchospasm
- Considerations
- Tiotropium has antiinflammatory properities and decreases mucus secretion
Pilocarpine (Pilocar)
- Mechanism
- Direct Cholinergic Agonist
- Contracts Iris Sphincter
- Contracts Ciliary Muscle
- Indications
- Xerostomia
- Glaucoma
- Side Effects
- Detached Retina
- Decreased Visual Acuity
- Eye Irritation
- Cholinergic Effects
- Considerations
- Avoid with Asthma or Bradycardia
2 mins
Ephedrine
- Mechanism of Action
- Alpha Agonist
- Beta Agonist
- Indications
- Rhinitis
- Hypotension
- Urinary Incontinence
35 secs
Indirect Cholinomimetics
- Acetylcholinesterase Inhibitors
- Doesn't Cross BBB
- Edrophonium
- Myasthenia Gravis (Diagnosis)
- Pyridostigmine and Neostigmine
- Myasthenia Gravis (Tx)
- Ileus
- Crosses BBB
- Physostigmine
- Atropine Overdose
- Glaucoma
- Donepezil
- Alzheimer's
2 mins
Selective Alpha-2 Blockers
- Mirtazapine
- Indications
- Depression Treatment
- Mechanism of Action
- Blocks Alpha2 Receptor
- Antagonist at 5-HT receptors
- Side Effects
- Sedation
- Weight gain
- Increased Serum Cholesterol
1 min
Local anesthetics
- caine suffix
- Esters
- Benzocaine
- Procaine and Chloroprocaine
- Tetracaine
- Cocaine
- Amides
- Articaine
- Bupivacaine and Levobupivacaine
- Lidocaine
- Mepivacaine
- Prilocaine
- Ropivacaine
- Short Half Life
- Methemoglobinemia
- Cardiotoxicity
- Post-operative pain
- No Vasodilation
- Ortho-toluidine
- EMLA
- Transient neurologic symptoms
- Metabolized by Cytochrome P450s
- Metabolized by plasma Butyrylcholinesterase
- Voltage-Gated Sodium Channel Blockers
Aromatase Inhibitors
- Indications
- Estrogen Receptor-positive (ER+) Breast Tumors
- Systemic Metastases
- Drugs
- Reversible, non-steroid
- Letrozole
- Anastrozole
- Irreversible, steroid
- Exemestane
- Side Effects
- Osteoporosis
- Arthritis
1 min
Lymphatics
- Characteristics
- Recycles 10% of Interstitial Fluid
- Transport Large Lipids from Lacteals
- Unidirectional Valves
- Lymph Nodes Filter Lymph
- WBCs Monitor Lymph for Pathogens
- Merge with Veins
2 mins
Burkitt's Lymphoma
- Adolescents or young adults
- C-myc gene moves next to heavy chain Ig gene
- T 8;14
- Starry sky appearance
- Sheets of lymphocytes with interspersed macrophages
- Jaw lesion in endemic (African) form
- Pelvis or abdomen in non endemic form (American form)
- Associated with EBV
2 mins
Follicular Lymphoma
- Derives from Germinal Center
- Occurs in adults
- T14;18
- BCL 2 overexpression
- BCL 2 inhibits apoptosis
- Indolent
- Generalized lymphadenopathy
- Bone marrow involvement
2 mins
Mantle Cell Lymphoma
- Older Males
- Activation of Cyclin D Gene
- T 11;14
- CD5
- Poor Prognosis
55 secs
Adult T Cell Lymphoma
- Caused by HTLV 1
- Japan, West Africa, Caribbean
- Present with cutaneous lesions
- Aggressive
1 min
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