Angie Shared "Pharm I Week 9 Inflammation" - 19 Picmonics
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Pharm I Week 9 Inflammation
Rheumatoid Arthritis Interventions
- Lifestyle Modifications
- Heat and Cold Applications
- Therapeutic Exercise
- Balance Rest and Activity
- Drug Therapy
- NSAIDs
- DMARDs
- Glucocorticoids
- Considerations
- PT/OT
- Reconstructive Joint Surgery
2 mins
Rheumatoid Arthritis Assessment
- Mechanism
- Destruction of Connective Tissue and Synovial Membrane
- Signs and Symptoms
- Inflammation of Joints
- Morning Stiffness
- Nodules
- Joint Deformities
1 min
Osteoarthritis
- Mechanism
- Articular Cartilage Destruction
- Biomechanical Stress
- Aging
- Signs and Symptoms
- Asymmetric
- Pain Decreases with Rest
- Morning Stiffness Under 30 Minutes
- Crepitus
- DIP and PIP Joints
- Treatment
- Lifestyle Changes
- Acetaminophen or NSAIDs
2 mins
Methotrexate
- Indications
- Rheumatoid Arthritis
- Cancer
- Medical Abortion
- Mechanism
- Folic Acid Analog
- Inhibits Dihydrofolate Reductase
- Side Effects
- Pulmonary Fibrosis
- Myelosuppression is Treated with Leucovorin Rescue (Folinic Acid)
- Macrocytic Anemia
- Hepatitis
- Teratogenic
- Mucositis
2 mins
Prednisone (Glucocorticoids)
- Mechanism
- Glucocorticoid
- Indications
- Inflammatory Conditions
- Organ Transplant Rejection
- Side Effects
- Cataracts and Glaucoma
- Cushing's Syndrome
- Osteoporosis
- Immunosuppression
- Hyperglycemia
- Ulcers
- Considerations
- Adrenal Insufficiency
- Taper Gradually
2 mins
Systemic Lupus Erythematosus (SLE) Interventions
- Avoid Sunlight
- Drug Therapy
- Glucocorticoids
- Methotrexate
- NSAIDs
- Hydroxychloroquine
- Azathioprine
- Considerations
- Monitor for Renal Failure (ARF)
- Manage Pain
2 mins
Gout Treatment
- Acute (Acute-angle)
- NSAIDs
- Glucocorticoids
- Colchicine
- Impairs Leukocyte Chemotaxis
- Chronic Gout (Crone Goat)
- Inhibit Xanthine Oxidase
- Allopurinol
- Febuxostat
- Inhibit Reabsorption of Uric Acid
- Probenecid
1 min
Gout Disease
- Acute Inflammatory Monoarthritis
- Epidemiology
- Primarily in Males
- Pathophysiology
- Precipitation of Monosodium Urate Crystals
- Underexcretion of Uric Acid
- Overproduction of Uric Acid
- Negatively Birefringent, Needle-Shaped
- Symptoms
- Swollen, Red, Painful Joint
- Asymmetric Joint Distribution
- Podagra
- Tophus
- After Large Meal or Alcohol
2 mins
NSAIDs
- Indications
- Anti-inflammatory
- Analgesic
- Fever
- Closure of Patent Ductus Arteriosus
- Mechanism of Action
- Reversible Inhibition of COX-1 and COX-2
- Block Prostaglandin Synthesis
- Side Effects
- Interstitial Nephritis
- Gastric Ulcer
- Renal Ischemia
1 min
Aspirin
- Indications
- Fever
- Pain and Headache
- Cardiovascular Disease (CAD)
- Mechanism of Action
- Irreversible inhibition of COX-1 and COX-2
- Suppress Thromboxanes and Prostaglandins
- NSAID
- Side Effects
- Reye's Syndrome
- Tinnitus
- Peptic Ulceration
- Mixed Acidosis/Alkalosis
- Nephropathy
2 mins
Aspirin Poisoning (Salicylism) Assessment
- Early Symptoms
- Nausea and Vomiting
- Tinnitus
- Confusion
- Hyperventilation
- Respiratory Alkalosis
- Late Symptoms
- Metabolic Acidosis
- Coma
- Hyperthermia
1 min
Reye's Syndrome
- Cause
- Aspirin (Salicylates) to Treat Viral Illness (In Children)
- Assessment
- Cerebral Edema
- Lethargy (Decreased LOC)
- Vomiting
- Liver Failure
- Interventions
- Monitor for Increased ICP
- Mannitol (Osmitrol)
- Considerations
- No Aspirin for Children
2 mins
Ibuprofen (Advil, Motrin)
- Mechanisms
- NSAID
- COX Inhibitor
- Indications
- General Pain
- Fever
- Inflammatory Conditions
- Side Effects
- GI Ulcers
- Nephrotoxicity
- Rash
- Considerations
- Avoid with Alcohol
- Risk of Thrombotic Event
2 mins
Celecoxib
- Indications
- Rheumatoid Arthritis
- Osteoarthritis
- Pain
- Mechanism of Action
- NSAID
- Selectively Inhibits COX-2
- Side Effects
- Sulfa Allergy
- Increased Risk of Thrombosis
- GI Bleed
- Contraindication
- Pregnancy > 30 Weeks
1 min
Acetaminophen Antidote
- Antidote
- N-Acetylcysteine
33 secs
Migraine Headache Treatments
- Acute Treatment
- Avoid Triggers
- Sumatriptan
- NSAIDs
- Preventative Treatment
- Beta Blockers
- Calcium Channel Blockers
- Amitriptyline
- Topiramate (Anticonvulsants)
1 min
Migraine Headaches Signs and Symptoms
- Signs and Symptoms
- More Common in Women
- Exacerbated by Activity
- Unilateral Pulsating Pain
- Aura
- Photophobia and Phonophobia
- Nausea/Vomiting
- Duration
- 4 hours to 3 Days
1 min
Sumatriptan
- Mechanism of Action
- Short Half-Life
- 5-HT Agonist
- Inhibits Trigeminal Nerve Activation
- Induces Vasoconstriction
- Indications
- Migraine
- Cluster Headache
- Side Effects
- Increased Risk of Serotonin Syndrome
- Paresthesias
- Coronary Vasospasm
- Contraindication
- Prinzmetal's Angina
- Coronary Artery Disease (CAD)
3 mins
Acetaminophen
- Indications
- Fever
- Pain
- Mechanism of Action
- Reversibly Inhibits COX
- Acts Primarily in CNS
- Side Effect
- Hepatic Necrosis
- N-acetylcysteine Antidote
51 secs
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