Lauren Shared "Pharm Module 3" - 34 Picmonics
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Pharm Module 3
Local Anesthetic Overview
- Indications
- Minor Procedures
- Epidurals
- Mechanism of Action
- Blocks Na+ Channels
- State Dependent
- Combined with Vasoconstrictors
- Infected Tissue Requires Higher Dose
- Drugs
- Esters
- Amides
- Side Effects
- Arrhythmias
- Cardiotoxicity
1 min
Inhaled Anesthetics
- Mechanism of Action
- Unknown Mechanism
- Inhaled Anesthetic Drugs
- HEISMN Drug Name Acronym
- Side Effects
- Respiratory Depression
- Myocardial Depression
- Lower Metabolic Demand, Increased Cerebral Blood Flow
- Hepatotoxicity (Halothane)
- Nephrotoxicity (Methoxyflurane)
- Seizure (Enflurane)
- Malignant Hyperthermia
- Expansion of Trapped Gas
2 mins
IV Anesthetics
- Barbiturates
- Benzodiazepines
- Respiratory Depression
- Hypotension
- Ketamine
- NMDA Receptor Antagonist
- Hallucinations
- Opioids
- Propofol
- Potentiates GABA-A
2 mins
Succinylcholine
- Indications
- Inducing Paralysis
- Mechanism of Action
- Neuromuscular Blocking Drugs
- Motor Nicotinic Receptor
- ACh Receptor Agonist
- Depolarization
- Phases of Action
- Phase I (Paralysis Non-reversible)
- Phase II (Paralysis Reversible)
- Neostigmine (Reversal Agent)
2 mins
Cyclophosphamide
- Mechanism
- Requires Bioactivation by Liver
- Cross-links DNA
- Guanine N7 Position
- Indications
- Autoimmune Disorders
- Leukemia
- Lymphoma
- Solid Tumors
- Side Effects
- Myelosuppression
- Hemorrhagic Cystitis
- Prevent with Mesna
3 mins
Cisplatin
- Indications
- Carcinomas
- Ovarian
- Bladder
- Lung
- Testicular
- Mechanism
- Cross-Links DNA
- Side Effects
- Ototoxicity
- Nephrotoxicity
- Treat with Amifostine and Chloride Diuresis
2 mins
Busulfan
- Indications
- CML
- Bone Marrow Ablation
- Mechanism
- Cross-Links DNA
- Side Effects
- Myelosuppression
- Pulmonary Fibrosis
- Hyperpigmentation
55 secs
Methotrexate
- Indications
- Rheumatoid Arthritis
- Cancer
- Medical Abortion
- Mechanism
- Folic Acid Analog
- Inhibits Dihydrofolate Reductase
- Side Effects
- Pulmonary Fibrosis
- Myelosuppression is Treated with Leucovorin Rescue (Folinic Acid)
- Macrocytic Anemia
- Hepatitis
- Teratogenic
- Mucositis
2 mins
Fluorouracil (5-FU)
- Mechanism
- Antimetabolite
- "Thymine-less Death"
- Indications
- Slow-growing Solid Tumors
- Co-administered with Leucovorin for Stomach Cancer
- Basal Cell Carcinoma (Topical)
- Side Effects
- Myelosuppression
- Mucositis
- Severe Diarrhea
3 mins
Etoposide
- Indications
- Small Cell Lung Cancer
- Testicular Cancer
- Mechanism of Action
- Inhibits Topoisomerase II
- Errors in DNA Synthesis Cause Apoptosis
- Side Effects
- Myelosuppression
- Alopecia
- Hypotension
- Nausea and Vomiting
2 mins
Doxorubicin (Adriamycin)
- Indications
- Solid Tumors
- Lymphomas and Leukemias
- Mechanism
- Free Radical Production
- Intercalates DNA
- Prevents Double Helix from Sealing
- Side Effect
- Cardiotoxicity
- Dexrazoxane Decreases Toxicity
1 min
Bleomycin
- Indications
- Testicular Cancer
- Hodgkin's Lymphoma
- Mechanism of Action
- Induces Free Radical Formation
- Breaks in DNA Strands
- Side Effects
- Pulmonary Fibrosis
- Skin Changes
- Mucositis
1 min
Imatinib (Gleevec)
- Indications
- Chronic Myelogenous Leukemia (CML)
- Inhibitor of BCR-ABL Tyrosine Kinase
- Caused by Philadelphia Chromosome
- GI Stromal Tumors
- Inhibitor of C-kit Tyrosine Kinase
- Toxicity
- Fluid Retention
1 min
Tamoxifen
- Mechanism of Action
- Selective Estrogen Receptor Modulator (SERM)
- Antagonist on Breast Tissue
- Indications
- ER-positive Breast Cancer
- Side Effects
- Decreased Risk of Osteoporosis
- Increased Risk of Endometrial Cancer
- Increased Risk of Venous Thromboembolism (VTE)
1 min
Dactinomycin (Actinomycin D)
- Indications
- Wilms' Tumor
- Rhabdomyosarcoma
- Ewing's Sarcoma
- Gestational Trophoblastic Malignancy
- Mechanism
- Intercalates DNA
- Side Effect
- Myelosuppression
1 min
Vincristine (Oncovin)
- Mechanism
- Vinca Alkaloid
- Inhibits Microtubules
- Indications
- Leukemias
- Lymphomas
- Side Effects
- Peripheral Neuropathy
- Paralytic Ileus
- Considerations
- Vesicant
2 mins
Cetuximab and Panitumumab
- Mechanism
- Monoclonal Antibodies Against EGFR
- Indications
- Colorectal Cancer
- Head and Neck Cancer
- Ménétrier Disease
- Side Effects
- Elevated LFTs
- Rash
- Diarrhea
- Hypokalemia
- Hypomagnesemia
1 min
H2 Receptor Blocker
- "-tidine" Suffix
- Indications
- Gastroesophageal Reflux Disease (GERD)
- Peptic Ulcer
- Mechanism
- Block Histamine H2 Receptors
- Parietal Cells
52 secs
H2 Receptor Blocker Side Effects
- Side Effects
- Decrease Creatinine Clearance
- Cimetidine
- Crosses Blood-Brain Barrier
- Anti-Androgen
- Inhibits Cytochrome P450
1 min
Proton Pump Inhibitors (PPIs)
- "-prazole" Suffix
- Indications
- Zollinger-Ellison Syndrome
- Gastritis
- Peptic Ulcer
- Gastroesophageal Reflux Disease (GERD)
- Mechanism
- Inhibit H+/K+/ATPase
- Side Effects
- Hip fracture
- Pneumonia
2 mins
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