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Along with IgG
C3a, C4a, C5a
Neutrophil chemotaxis (C5a)
Membrane Attack Complex (MAC)
Defective Bruton Tyrosine Kinase
Blocks B Cell Maturation
Signs & Symptoms
Decreased Immunoglobulins of All Classes
Bacterial Infections After Six Months
Maternal IgG Protects Before Six Months
Selective IgA Deficiency
Defect in Class Switching
Signs and Symptoms
Increase in Atopic & Autoimmune Diseases
Increased Risk Giardia Lamblia Infections
Inflammatory Bowel Disease
Anaphylaxis From IgA Containing Blood Products
Common Variable Immunodeficiency
Defect in B Cell Maturation
Decreased Plasma Cells
Signs & Symptoms
Increased Risk of Autoimmune Disease
Thymic Aplasia (DiGeorge Syndrome)
Failure to Develop Third and Fourth Pharyngeal Pouches
Blocks T cell activation and B cell differentiaion by preventing response to IL-2
Kidney Transplant rejection prophylaxis
Side effect: Pancytopenia
Side effect: Increased Insulin Resistance
Side effect: Hyperlipidemia
Also used in drug eluting stents
Monoclonal Antibody; blocks IL-2
Tx: Kidney Transplant Rejection Prophylaxis
Side effect: Edema
Side effect: Hypertension
Side effect: Tremor
-ximab = Chimeric monoclonal Ab
-zumab = Humanized monoclonal antibody
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