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2- Immunology
Complement
C3b
Opsonization
Along with IgG
C3a, C4a, C5a
Anaphylaxis
Neutrophil chemotaxis (C5a)
C5b-9
Membrane Attack Complex (MAC)
Bruton's Agammaglobulinemia
Pathophysiology
X-linked Recessive
Defective Bruton Tyrosine Kinase
Blocks B Cell Maturation
Signs & Symptoms
Decreased Immunoglobulins of All Classes
Bacterial Infections After Six Months
Maternal IgG Protects Before Six Months
2 mins
Selective IgA Deficiency
Pathophysiology
Defect in Class Switching
Decreased IgA
Signs and Symptoms
Often Asymptomatic
Increase in Atopic & Autoimmune Diseases
Sinopulmonary Infections
Increased Risk Giardia Lamblia Infections
Inflammatory Bowel Disease
Celiac Disease
Considerations
Anaphylaxis From IgA Containing Blood Products
2 mins
Common Variable Immunodeficiency
Pathophysiology
Defect in B Cell Maturation
Decreased Plasma Cells
Decreased Immunoglobulins
Signs & Symptoms
Sinopulmonary Infections
Increased Risk of Autoimmune Disease
Lymphoma
1 min
Thymic Aplasia (DiGeorge Syndrome)
Pathophysiology
DiGeorge Syndrome
22q11 Deletion
Failure to Develop Third and Fourth Pharyngeal Pouches
Blocks T cell activation and B cell differentiaion by preventing response to IL-2
Kidney Transplant rejection prophylaxis
Side effect: Pancytopenia
Side effect: Increased Insulin Resistance
Side effect: Hyperlipidemia
Also used in drug eluting stents
NOT nephrotoxic
Daclizumab, Basiliximab
Daclizumab, Basiliximab
Monoclonal Antibody; blocks IL-2
Tx: Kidney Transplant Rejection Prophylaxis
Side effect: Edema
Side effect: Hypertension
Side effect: Tremor
-ximab = Chimeric monoclonal Ab
-zumab = Humanized monoclonal antibody
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