Chuck Shared "MICRO-RX" - 62 Picmonics

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MICRO-RX

Macrolides Side Effects
Side Effects
Diarrhea
Prolonged QT Interval
P450 Inhibitor
Cholestatic Hepatitis
Skin Rash
Eosinophilia
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2 mins
Vancomycin Side Effects & Toxicity
Side Effects
Thrombophlebitis
Nephrotoxicity
Ototoxicity
Diffuse Flushing Called Red Man Syndrome
Prevent with Antihistamine
Prevent with Slow Infusion
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2 mins
Tetracycline Toxicities
Inhibition of Bone Growth in Children
Teratogen
Discoloration of Teeth
Photosensitivity
GI Distress
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2 mins
Fluoroquinolones Toxicities
Diarrhea
Skin Rash
Headache
Tendon Rupture in Adults
Myalgias in Kids
Damage to Cartilage
Teratogen
QT Prolongation
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1 min
Sulfonamides Side Effects
Side Effects
Hypersensitivity
Nephrotoxicity
Photosensitivity
Kernicterus in Infants
Displaces Warfarin from Albumin
Considerations
Hemolysis with G6PD Deficiency
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3 mins
Foscarnet
Indications
CMV Retinitis
Acyclovir-resistant HSV
Mechanism
Does Not Require Activation (by Viral Kinase)
Inhibits Viral DNA Polymerase
Pyrophosphate Analog
Resistance through Mutated DNA Polymerase
Side Effects
Nephrotoxicity
Electrolyte Abnormalities
Hypokalemia
Hypocalcemia
Hypomagnesemia
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2 mins
Ganciclovir
Indications
Cytomegalovirus (CMV)
Immunocompromised
Mechanism
Guanosine Analog
Disrupts DNA Synthesis
Inhibits Viral DNA Polymerase
Side Effects
Hematologic Effects
Nephrotoxicity
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1 min
Ribavirin
Mechanism
Hypermutation in RNA Viruses
Inhibits Inosine Monophosphate Dehydrogenase
Indications
Hepatitis C
Viral Hemorrhagic Fevers
Respiratory Syncytial Virus (RSV)
Side Effects
Hemolytic Anemia
Teratogen
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1 min
Fusion Inhibitors
Indications
HIV
Drugs
Maraviroc
Binds CCR-5 on T Cells
Blocks Interaction with gp120
Enfuvirtide
Binds gp41
Inhibits Viral Entry
Side Effects
Skin Reactions at Injection Sites (Enfuvirtide)
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2 mins
Protease Inhibitors
End in "-navir"
Indications
HIV/AIDS
Hepatitis C
Mechanism
Inhibit Protease
Unable to Cleave Proteins
Inhibits Maturation of New Virus
Side Effects
GI Distress
Nephropathy
Lipodystrophy
Hyperglycemia
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3 mins
Integrase Inhibitors
-gravir Suffix
Indications
HIV
Mechanism
Blocks Insertion of Viral Genome
Inhibit Actions of Integrase
Side Effects
Hypercholesterolemia
Increased LFT's
Insomnia
Increased Creatine Kinase (CK)
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1 min
NRTIs (Nucleoside Reverse Transcriptase Inhibitors)
Indications
HIV
Pregnancy and Prophylaxis given ZDV
Mechanism
Inhibit Nucleotide Binding to Reverse Transcriptase
Chain Termination
Require Phosphorylation
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1 min
Cidofovir
Indications
CMV Retinitis
Acyclovir-resistant HSV
Mechanism
Inhibits Viral DNA Polymerase
Side Effects
Nephrotoxicity
Administer with Probenecid and IV Saline
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1 min
Zanamivir (Relenza) and Oseltamivir (Tamiflu)
Indications
Influenza A and B
Treatment and Prophylaxis
Mechanism
Inhibits Release of New Virus
Inhibits Influenza Neuraminidase
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1 min
HAART
HIV
Begin at Diagnosis
3 Drugs
2 NRTIs (Nucleoside Reverse Transcriptase Inhibitors)
And one of the following:
NNRTI (Non-Nucleoside Reverse Transcriptase Inhibitor)
or Protease Inhibitor
or Integrase Inhibitor
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2 mins
NRTI Toxicity
Bone Marrow Suppression
Reverse with G-CSF and Erythropoietin
Rash
Neuropathy
Anemia
Pancreatitis
Lactic Acidosis
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1 min
NNRTIs (Non-nucleoside Reverse Transcriptase Inhibitors)
Indications
HIV
Mechanism
Do Not Require Intracellular Metabolism
Inhibits Reverse Transcriptase
Side Effects
Rash
Hepatotoxicity
Vivid Dreams and CNS Symptoms
Contraindication
Pregnancy
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2 mins
Acyclovir (Zovirax)
Mechanism
Guanosine Analog
Inhibits Viral Replication
Thymidine Kinase Activation
Indications
Herpes Simplex Virus (HSV)
Varicella Zoster Virus (VZV)
Side Effects (Oral)
Headache
GI Distress
Side Effects (IV)
CNS Toxicity
Nephrotoxicity (Crystalline Nephropathy)
Considerations
Prevents Recurrent Episodes
Slow IV Infusion
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2 mins
Clindamycin
Mechanism of Action
Bacteriostatic
Binds 50S Ribosomal Subunit
Blocks Translocation
Indications
Anaerobic Infections above the Diaphragm
Aspiration Pneumonia
Lung Abscess
Side Effects
Can Cause Pseudomembranous Colitis
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1 min
Macrolides
Bacteriostatic
Erythromycin
Azithromycin
Clarithromycin
Bind to 23S rRNA of 50S subunit
Inhibit protein synthesis by blocking translocation
Gram-Positive Cocci
Atypical pneumonia
Chlamydia
Resistance by methylation of 23S rRNA binding
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1 min

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