Jonathan Shared "Path Block 2" - 37 Picmonics
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Path Block 2
Nephrotic Syndrome
- Signs and Symptoms
- Massive Proteinuria > 3.5g per Day
- Edema
- Increased risk of infection
- Thromboembolism
- Hyperlipidemia
- Fatty casts
1 min
Minimal Change Disease
- Pathophysiology
- Nephrotic
- Most Common in Children
- May be Triggered by Recent Infection or Immune Stimulus
- Diagnosis
- On Electron Microscopy (EM) See Foot Process (Podocyte) Effacement
- On Light Microscopy (LM) See Normal Glomeruli
- Loss of Negative Charge
- Selective Loss of Albumin
- Treatment
- Responds to Corticosteroids
2 mins
Focal Segmental Glomerulosclerosis
- Most Common Cause of Nephrotic Syndrome in Hispanic People and African Americans
- Associated with Sickle Cell Disease and HIV
- Associated Interferon Therapy and Heroin Abuse
- Histopathology
- LM Segmental Sclerosis and Hyalinosis
- EM Focal Damage of Visceral Epithelial Cells
- IF Negative
- Signs & Symptoms
- Microscopic Hematuria
- Nonselective Proteinuria
- Considerations
- Poor Prognosis
2 mins
Membranous Glomerulonephritis
- Characteristics
- Nephrotic
- Diagnosis
- LM Thickening of Capillary and Glomerular Basement Membrane (GBM)
- EM Spike and Dome Appearance with Subepithelial Deposits
- IF Granular
- Primary
- Phospholipase A2 Receptor Autoantibodies
- Secondary
- NSAIDS
- Gold
- Solid Tumors
- Hepatitis B Virus (HBV)
- Lupus
3 mins
Membranoproliferative Glomerulonephritis
- Nephritic-Nephrotic Syndrome
- Type I
- Subendothelial Immune Complexes
- Hepatitis C Virus
- Granular IF
- Tram Tracks Caused by Splitting of the GBM
- Ingrowth of Mesangium
- Type II
- Dense Deposit Disease
- C3 Nephritic Factor
2 mins
Diabetic Glomerulonephropathy
- Pathophysiology
- Nonenzymatic Glycosylation of Glomerular Basement Membrane
- Nonenzymatic Glycosylation of Arterioles
- Hyperfiltration
- Increased GFR
- Histological Findings
- Hyaline Arteriolosclerosis
- Mesangial Expansion
- Type IV Collagen Deposition
- Kimmelstiel Wilson Lesions
- Presentation
- Nephrotic
2 mins
Nephritic Syndrome
- Inflammatory
- Hematuria
- RBC casts
- Increased Nitrogen in blood
- Oliguria
- Hypertension
- Proteinuria < 3.5 grams per day
2 mins
Post Streptococcal Glomerulonephritis
- Pathophysiology
- Nephritic
- Children
- Signs and Symptoms
- Edema
- Cola Colored Urine
- Follows Group A Streptococcal pharyngitis or Skin Infection
- Diagnosis
- Neutrophils
- Immunofluorescence (IF) Granular
- Lumpy Bumpy Appearance on Immunofluorescence (IF)
- Subepithelial Immune Complex Humps
2 mins
Rapidly Progressive Glomerulonephritis
- Pathogenesis
- Nephritic Syndrome
- Crescent Shape
- Crescents Consist of Fibrin and C3b
- With Parietal Cells, Monocytes, and Macrophages
- IMMUNOFLUORESCENCE
- Linear Immunofluorescence
- Negative Immunofluorescence
- Granular Immunofluorescence
- Etiology
- Goodpasture Syndrome
- Granulomatosis with Polyangiitis (Formerly Wegener's)
- Microscopic Polyangiitis
- Prognosis
- Poor Prognosis
3 mins
Berger's Disease (IgA Nephropathy)
- Nephritic
- IgA Nephropathy
- Immune Complex Deposit in Mesangium
- Increased Synthesis of IgA
- Most Common Cause of Nephritic Syndrome
- Overlapping Features with Henoch–Schönlein Purpura
- Presents with Pharyngitis, URI or Acute Gastroenteritis
1 min
Alport Syndrome
- Pathophysiology
- Nephritic
- X-linked
- Mutation in Type IV Collagen
- Diagnosis
- Split Basement Membrane
- Basket Weave Appearance
- Signs and Symptoms
- Ocular Disorders
- Deafness
2 mins
E. coli Overview
- Characteristics
- Gram-Negative
- Bacillus
- Purple Colony with Metallic Green Sheen
- Lactose-Fermenting
- Pink on MacConkey Agar
- Disease
- Diarrhea
- Lipid A Septic Shock
- P Pili Pyelonephritis and Cystitis
- K Capsule Neonatal Meningitis
- K Capsule Pneumonia
- H Antigen Flagella
2 mins
Staphylococcus saprophyticus
- Characteristics
- Gram-Positive
- Cocci
- Catalase-Positive
- Coagulase-Negative
- Novobiocin-Resistant
- Urease-Positive
- Disease
- Urinary Tract Infections (UTI's)
1 min
Proteus Mirabilis
- Characteristics
- Gram-Negative
- Bacillus
- Oxidase Negative
- Urease-Positive
- Swarming Motility
- Non-lactose Fermenting
- Symptoms
- Urinary Tract Infection
- Struvite Crystals
- Staghorn Kidney Stones
2 mins
Enterococci
- Characteristics
- Gram-Positive Cocci
- Catalase Negative
- 6.5% NaCl
- Grows in Bile
- Normal Colonic Flora
- Signs and Symptoms
- Urinary Tract Infection
- Subacute Endocarditis
- Penicillin Resistant
- VRE (Vancomycin Resistant Enterococci)
2 mins
Wilms' Tumor (Nephroblastoma)
- Cause
- Malignant Renal Tumor
- Assessment
- Abdominal Mass
- Hematuria
- Fever
- Hypertension
- Interventions
- Nephrectomy
- Chemotherapy
- Radiation
- Considerations
- Do Not Palpate Abdomen
- Children Under 5 Years Old
2 mins
Squamous Cell Carcinoma of the Skin
- Epidemiology
- 2nd Most Common Skin Cancer
- UV Light Exposure
- Long-term Immunosuppression
- Arsenic Exposure
- Signs/Symptoms
- Ulcerative Red Lesion
- Precursor Actinic Keratosis
- Commonly Lower Lip
- Diagnosis
- Biopsy shows Keratin Pearls
- Treatment
- Mohs Micrographic Surgery
2 mins
Epstein Barr Virus
- Characteristics
- Herpesvirus 4
- Double Stranded DNA
- Linear
- Enveloped
- Signs and Symptoms
- Infectious Mononucleosis
- Virus Attaches to CD21 in B Cells
- Nasopharyngeal Carcinoma
- Burkitt's Lymphoma
- Hodgkin's Lymphoma
1 min
Haemophilus Influenzae Disease
- Disease
- Pneumonia
- Cherry Red Epiglottitis
- Meningitis
- Otitis Media
- COPD Exacerbation
- Thumbprint Sign (on X-ray)
- Treatment
- Rifampin Prophylaxis
- Ceftriaxone
2 mins
Croup (Laryngotracheobronchitis)
- Mechanism
- Parainfluenza Virus
- Assessment
- 3 Months to 3 Years
- Nighttime
- Barking Seal Cough
- Inspiratory Stridor
- Interventions
- Cool Humidified Air
- Dexamethasone
- Racemic Epinephrine
2 mins
