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HSF Week 08
GI Absorption
Stomach
Alcohol
Duodenum
Iron
Jejunum
Folate
Terminal Ileum
Vitamin B12
Bile Resorption
1 min
Small Intestine Digestion
Brush border enzymes
Pancreatic Enzymes are secreted via a Duct
Pancreas secretes bicarbonate
Brush Border activates Pancreatic Trypsin
Trypsin activates Chymotrypsin
Trypsin and Chymotrypsin digest Proteins
Gallbladder Releases Bile
Pancreatic Lipase breaks down Lipids
Goblet cells secrete mucus
Pancreatic Amylase breaks down Carbohydrates
Pancreatic Nucleases breakdown DNA/RNA
Digestion occurs in the Duodenum
2 mins
Small Intestine Absorption
Characteristics
Carbohydrates Undergo Active Transport
Amino Acids Undergo Active Transport
Small Lipids Undergo Passive Diffusion
Epithelial Cells
Intestinal Capillaries
Hepatic Portal Transports Nutrients
Liver
Large Lipids Transported as Chylomicrons
Lacteals Transport Chylomicrons
2 mins
Large Intestine
Characteristics
Colon
Electrolyte Reabsorption
Water Reabsorption
Microflora Produce Vitamins
Rectum Stores Feces
1 min
Iron Deficiency Anemia
Causes
Malnutrition/Malabsorption
Hemorrhage
Signs
Microcytic, Hypochromic Anemia
Decreased Heme Synthesis
Labs
Decreased Reticulocytes
Decreased Ferritin
Increased Red Cell Distribution Width (RDW)
Poikilocytosis
Anisocytosis
Increased Central Pallor
2 mins
Vitamin C Mechanism and Deficiency
Mechanism
Ascorbic acid
Antioxidant
Protects Against Free Radicals
Keeps Iron in Reduced State
Hydroxylation of Proline and Lysine
Necessary for Dopamine B Hydroxylase
Deficiency Signs and Symptoms
Scurvy
Swollen Gums
Bruising
Poor Wound Healing
Hemarthrosis
Perifollicular Hemorrhages
Anemia
4 mins
Vitamin B12 (Cobalamin) Mechanism and Deficiency
Mechanism
Cobalamin
Large reserve pool in the liver
Homocysteine to methionine
Methylmalonyl CoA to succinyl CoA
Deficiency Signs and Symptoms
Macrocytic Megaloblastic Anemia
Hypersegmented Neutrophils
Neurologic defects
Posterior column
Lateral corticospinal tract
Spinocerebellar tract
5 mins
Vitamin K
Sources
Dark Green Leafy Vegetables
Synthesized by Intestinal Flora
Mechanism
Activated by Epoxide Reductase
Gamma Carboxylation of Glutamate
Activation of Clotting Factors II, VII, IX, X, Protein C and S
Considerations
Deficiency with Broad Spectrum Antibiotics
Neonatal Hemorrhage with Increased PT and aPTT
Warfarin is a Vitamin K Antagonist
4 mins
Deep Gluteal Muscles
General Action
Lateral Rotation and Abduction
Muscles
Gluteus Minimus
Medially Rotates Leg
Piriformis
Superior Gemellus
Obturator Internus
Inferior Gemellus
Quadratus Femoris
Other Structures
Sacrotuberous Ligament
1 min
Leg Nerves
Femoral
Saphenous
Posterior Femoral Cutaneous
Sciatic
Tibial
Common Peroneal
Superficial Peroneal
Deep Peroneal
1 min
Dermatomes - Lumbosacral
L2 - Medial Thigh
L3 - Medial Knee
L4 - Kneecap, Medial Ankle, and Big Toe
L5 - Dorsum of Foot
S1 - Lateral Foot, Posteriolateral Thigh
S 2, 3, 4, 5 - Perianal and Genitals
2 mins
Medial Thigh Muscles
Action
Adduct the Thigh
Innervation
Obturator Nerve
Muscles
Adductor Magnus
Tibial Nerve
Adductor Longus
Adductor Brevis
Gracilis
Obturator Externus
Laterally Rotates Thigh
1 min
Posterior Lower Leg Anatomy
Superficial Compartment
Calcaneal Tendon
Superficial Muscles
Gastrocnemius
Soleus
Plantaris
Deep compartment
Deep Muscles
Popliteus
Tibialis Posterior
Flexor Digitorum Longus
Flexor Hallucis Longus
Innervation
Tibial Nerve
2 mins
Anterior Thigh Muscles
Innervation
Femoral Nerve
Muscles
Iliopsoas
Psoas Innervated by L1-3
Sartorius
Pectineus
Quadriceps Femoris
Vastus Lateralis
Vastus Intermedius
Vastus Medialis
Rectus Femoris
2 mins
Vibrio Cholera Disease
ADP Ribosylating AB Toxin
Turn Gs on Causing Increase in cAMP
Secretion of Cl
Blocks Reabsorption of Na
Rice Water Diarrhea
1 min
E. coli Overview
Characteristics
Gram-Negative
Bacillus
Purple Colony with Metallic Green Sheen
Lactose-Fermenting
Pink on MacConkey Agar
Disease
Diarrhea
Lipid A Septic Shock
P Pili Pyelonephritis and Cystitis
K Capsule Neonatal Meningitis
K Capsule Pneumonia
H Antigen Flagella
2 mins
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