Zelik Shared "True learn musculoskeletal and skin " - 26 Picmonics
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True learn musculoskeletal and skin
Polymyalgia Rheumatica
- General Characteristics
- Proximal Muscle Pain
- Normal Muscle Strength
- Morning Stiffness
- Age Over 50
- Associated With Temporal Arteritis
- Diagnosis
- Elevated ESR, CRP
- Normal CK
- Management
- Corticosteroids
4 mins
Polymyositis / Dermatomyositis Disease
- Pathophysiology
- Idiopathic Inflammatory Myopathy
- More Common in Women
- Endomysial Inflammation with CD8+ Cells (Polymyositis)
- Perimysial Inflammation with CD4+ Cells (Dermatomyositis)
- Signs and Symptoms (Both)
- Symmetric Proximal Muscle Weakness
- Dysphagia
- Lung and Cardiac Involvement
- Signs and Symptoms (Dermatomyositis)
- Malar Rash
- Shawl-like Shoulder Rash
- Gottron Papules on Knuckles
- Heliotrope Rash
3 mins
Muscular Dystrophy
- Mechanism
- X-linked Recessive
- Signs and Symptoms
- Muscle Weakness
- Motor Problems
- Gower Sign
- Large Calves
- Waddling Gait
- Loss of Ambulation
- Consideration
- Cardiac and Respiratory Failure
2 mins
Duchenne and Becker Muscular Dystrophy
- Duchenne
- Frameshift Mutation
- X-linked recessive
- Progressive myofiber damage
- Truncated or absent dystrophin protein
- Muscle Weakness. Weakness begins in pelvic girdle muscles and progresses superiorly.
- Motor Problems
- Pseudohypertrophy of calf muscles due to fibrofatty replacement of muscle
- Onset before 5 years of age
- Gower Sign
- Waddling Gait
- Loss of Ambulation
- Dilated cardiomyopathy common cause of death
- Respiratory Failure
- Myonecrosis
- Increased CPK and Aldolase
- Confirmed with Western Blot and Muscle Biopsy
- Becker
- X-linked disorder typically due to nonframeshift deletions in dystrophin gene (partially functional instead of truncated)
- Becker is less severe and caused by Pinpoint missense mutation
- Onset in adolescence or early adulthood
Friedreich's Ataxia
- Trinucleotide Repeat
- GAA Repeat
- Frataxin
- Mitochondrial Dysfunction
- Autosomal Recessive
- Hammertoes
- High Arches
- Kyphoscoliosis
- Lateral Corticospinal Tract
- Posterior Column
- Spinocerebellar Tract
- Type I Diabetes Mellitus
- Hypertrophic Cardiomyopathy
1 min
McArdles Disease
- Pathophysiology
- Type V Glycogen Storage Disease
- Muscle Glycogen Phosphorylase Deficiency
- Signs and Symptoms
- Increased Glycogen in Muscle
- Painful Muscle Cramps
- Myoglobinuria
- Normal Lactic Acid
- Treatment
- Vitamin B6
2 mins
Mixed connective tissue disease
- Autoimmune-mediated tissue damage with mixed features of SLE, systemic sclerosis, and/or polymyositis
- Characterized by serum antibodies against U1 ribonucleoprotein (anti-U1 RNP antibodies).
Alkaptonuria
- Autosomal Recessive
- Deficiency of homogentisic acid oxidase
- In degradative pathway of tyrosine to fumarate
- Homogentisic acid harmful to cartilage
- Arthritis
- Dark Connective Tissue
- Urine turns black on standing
1 min
Chondrosarcoma
- Pathophysiology
- Cartilaginous tumor
- Malignant
- Men 30-60 years old
- Pelvic and femur bones
- Signs & Symptoms
- Glistening mass in medullary cavity
- Can be primary in origin or from osteochondroma
- Metastasize to lungs
1 min
Gauchers Disease
- Pathophysiology
- Autosomal Recessive
- Beta Glucocerebrosidase Deficiency
- Diagnosis
- Lipid-laden Macrophages
- Crumpled Tissue Paper
- Signs and Symptoms
- Osteoporosis
- Bone Crises
- Aseptic Necrosis of Femur
- Erlenmeyer Flask Deformity
- Hepatosplenomegaly
- Pancytopenia
2 mins
Polyarteritis Nodosa
- Pathophysiology
- Immune Complex-Mediated Transmural Vasculitis
- Hepatitis B Association
- Fibrinoid Necrosis
- Signs and Symptoms
- Black Stool (Melena)
- Neurologic Dysfunction
- Myalgia
- Fever
- Hypertension
- Diagnosis
- Vessels / Lesions in Different Stages
- Renal Microaneurysms (On Arteriogram)
- Spares Pulmonary Arteries (No Pulmonary Involvement)
- Treatment
- Corticosteroids
- Cyclophosphamide
2 mins
Erythema Infectiosum (Fifths Disease)
- Mechanism
- Human Parvovirus B19
- Signs and Symptoms
- Cold-like Symptoms
- Three Stage Rash
- Slapped Face
- Maculopapular Red Spots on Trunk
- Rash Reappears
- Considerations
- Aplastic Crisis
- Joint Pain and Swelling
2 mins
Rubella
- Characteristics
- RNA Virus
- Matonaviridae
- Enveloped
- Icosahedral
- SS Positive Linear
- Signs and Symptoms
- German Measles or Three-Day Measles
- Fever
- Postauricular Tenderness
- Lymphadenopathy
- Truncal Rash
- Arthritis
- Congenital TORCH Infection
2 mins
Roseola
- Exanthem
- Herpesvirus 6
- Enveloped
- Double Stranded DNA
- Linear
- Signs and Symptoms
- High Fevers Can Lead to Seizures
- Diffuse Macular Rash After Fever
1 min
Pemphigus Vulgaris
- Pathophysiology
- Autoantibodies against desmosomes
- Symptoms
- Flaccid Bullae on Skin
- Oral Mucosa Involvement
- Intraepidermal Acantholysis
- Fluid Loss
- Infection
- Nikolsky Positive
- Diagnosis
- Biopsy showing Autoantibodies
- Treatment
- IVIG and Plasmapheresis
- Oral Steroids
- Immunosuppressants
2 mins
Kawasaki Disease
- Pathophysiology
- Prevalent in Asian Children
- Necrotizing Vasculitis
- Signs and Symptoms
- Fever
- Strawberry-Red Tongue and Mucosa
- Lymphadenopathy
- Desquamative Skin Rash
- Erythema and Edema of the Hands and Feet
- Conjunctivitis
- Coronary Aneurysm
- Treatment
- Intravenous Immunoglobulin (IVIG)
- Aspirin
2 mins
Pityriasis Rosea
- Preceded by Upper Respiratory Tract Infection
- Single "Herald Patch"
- "Christmas Tree" Distribution
- Plaques with Collarette Scale
- Self-resolving in 6-8 Weeks
2 mins
Rubeola Virus
- Characteristics
- RNA Virus
- Paramyxovirus
- Signs and Symptoms
- Measles
- Rash Spreads From Head to Toe
- Koplik Spots First
- Red Spots with Blue-White Center on Buccal Mucosa
- Cough
- Coryza
- Conjunctivitis
- Subacute Sclerosing Panencephalitis
- Giant Cell Pneumonia in Immunosuppressed Patients
- Warthin-Finkeldey Multinucleated Giant Cells
- Treatment
- Vitamin A
3 mins
Parvovirus B19
- Characteristics
- DNA
- Single Stranded
- Linear
- Smallest DNA virus
- Non-enveloped
- Signs and Symptoms
- 5th Disease
- Slapped Cheek Rash in Children
- Erythema Infectiosum
- Hydrops Fetalis
- RBC aplasia
- Arthritis in Adults
- Aplastic Crisis in Sickle Cell
- Myocarditis
2 mins
Microscopic Polyangiitis
- Pathophysiology
- Necrotizing Small Vessel Vasculitis
- Signs and Symptoms
- Lungs, Kidneys, and Skin Commonly Affected
- Palpable Purpura
- Rapidly Progressive Cresentic Glomerulonephritis
- Diagnosis
- Lesions are Same Age
- Non-granulomatous
- Minimal Nasopharyngeal Involvement
- P-ANCA
- Treatment
- Corticosteroids
- Cyclophosphamide
2 mins
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