Katerina Shared "Endocrine" - 32 Picmonics
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Endocrine
Insulin
- Rapid Acting
- Insulin Lispro (Humalog)
- Insulin Aspart (Novolog)
- Insulin Glulisine (Apidra)
- Short Acting
- Regular Insulin (Humulin R)
- Intermediate Acting
- Isophane NPH (Humulin N)
- Long Acting
- Detemir (Levemir)
- Glargine (Lantus)
2 mins
Chlorpropamide and Tolbutamide (Orinase) (1st Generation Sulfonylureas)
- Mechanisms
- 1st Generation Sulfonylureas
- Stimulate Release of Insulin
- Indications
- Type 2 Diabetes
- Side Effects
- Hypoglycemia
- Possible Cardiovascular Toxicity
- Weight Gain
- Considerations
- Exacerbated Hypoglycemia with Beta-blockers
- Avoid During Pregnancy and Breast Feeding
- Avoid Alcohol
2 mins
Glyburide and Glipizide (2nd Generation Sulfonylureas)
- Mechanisms
- 2nd Generation Sulfonylureas
- Blocks Potassium Channels in Beta Cells
- Stimulate Release of Insulin
- Indications
- Type 2 Diabetes
- Side Effects
- Hypoglycemia
- Considerations
- More Potent
- Beta Blockers Reduce Effects
- Avoid Alcohol
- Avoid Breastfeeding
2 mins
Repaglinide and Nateglinide (Meglitinides)
- Mechanisms
- Meglitinides
- Increased Insulin Release
- Indications
- Type 2 Diabetes
- Side Effect
- Hypoglycemia
- Considerations
- Eat Within 30 Minutes
- Gemfibrozil Increases Risk of Hypoglycemia
- Short Half-Life
2 mins
Metformin
- Indications
- Diabetes Mellitus Type 2
- Polycystic Ovary Syndrome (PCOS)
- Mechanism of Action
- Decreased Gluconeogenesis
- Increased Insulin Sensitivity
- Side Effects
- Lactic Acidosis
- GI Distress
- Weight Loss
- B12 Deficiency
- Contraindication
- GFR < 30 ml/min
2 mins
Pioglitazone (Thiazolidinediones)
- -glitazones Suffix
- Mechanism
- Binds PPAR-Gamma
- Decreases Insulin Resistance
- Indications
- Type 2 Diabetes
- Side Effects
- Weight Gain
- Heart Failure
- Myalgia
- Hypoglycemia
- Upper Respiratory Infection
- Considerations
- Increased Risk of Bladder Cancer
- Increased Fracture Risk in Women
- Monitor Liver Enzymes
2 mins
Acarbose (Precose) and Miglitol (Glyset) (Alpha Glucosidase Inhibitors)
- Mechanisms
- Alpha Glucosidase Inhibitors
- Delays Absorption of Carbohydrates
- Indications
- Type 2 Diabetes
- Side Effects
- Flatulence
- Diarrhea
- Anemia
- Cramps
- Considerations
- Monitor LFTs
- Oral Glucose for Hypoglycemia
2 mins
Exenatide (Byetta)
- Mechanism
- Incretin Mimetic
- GLP-1 Synthetic Analog
- Indications
- Type 2 Diabetes
- Side Effects
- Hypoglycemia
- Nausea and Vomiting
- Diarrhea
- Thyroid Cancer
- Pancreatitis
- Renal Failure
- Considerations
- (Give Exenatide) One Hour After Other Medications
- Adjunct Therapy
3 mins
Sitagliptin (Januvia) and Saxagliptin (Onglyza) (DPP-4 Inhibitors)
- -gliptin Suffix
- Mechanisms
- DPP-4 Inhibitor
- Increases Insulin Release
- Indications
- Type 2 Diabetes
- Side Effects
- Pancreatitis
- Upper Respiratory Infection and Inflammation
- Stevens-Johnson Syndrome
- Considerations
- Used as Add-on Agents
2 mins
SGLT2 Inhibitors
- "-gliflozin" Suffix
- Mechanism of Action
- Blocks Glucose Reabsorption in Proximal Tubule
- Indications
- Type 2 Diabetes Mellitus
- Side Effects
- Weight Loss
- Lower Blood Pressure
- Hyperkalemia
- Urinary Tract Infections (UTIs)
1 min
Glucagon (GlucaGen)
- Mechanism
- Increases Glucose
- Indications
- Hypoglycemic Emergency
- Side Effects
- Nausea and Vomiting
- Considerations
- Reconstitute Powder
- Consume Oral Carbohydrates
- 50% Dextrose IV (If No Effect)
2 mins
Octreotide
- Indications
- Acute Variceal Bleeds
- Pituitary Tumors
- GH Secreting Tumors
- Carcinoid Tumors
- VIPoma
- Mechanism
- Somatostatin Analog
2 mins
Insulinoma
- Characteristics
- Pancreatic Neuroendocrine Tumor
- Benign
- Associated with MEN-1
- Clinical Features
- Whipple Triad
- Symptoms of Hypoglycemia
- Hypoglycemia During Episode
- Relief with Glucose
- Diagnosis
- Increased C-peptide
- Management
- Surgery
- Octreotide
- Diazoxide
2 mins
Levothyroxine
- Indications
- Hypothyroidism
- Myxedema Coma
- Mechanism of Action
- Isomer of Thyroid Hormone (T4)
- T3 has Higher Potency
- Side Effects
- Hyperthyroid Symptoms
57 secs
Hypothyroidism Intervention
- Medications
- Levothyroxine (Synthroid)
- Liothyronine (Cytomel)
- Complication
- Myxedema Coma
- Nursing Considerations
- Lifelong Replacement Hormone
- Monitor Vital Signs
- Fluids and Fiber
- Low Calorie, Low Fat Diet
- Medication Education
- No Switching Brands
2 mins
Graves' Disease Labs and Treatment
- Labs
- Decreased TSH
- Increased T3
- Increased T4
- Radioactive Iodine Uptake (RAIU)
- Treatment
- Beta blocker
- Methimazole
- Radioiodine Ablation
1 min
Propylthiouracil (PTU) and Methimazole (MMI)
- Indications
- Hyperthyroidism
- Mechanism
- Inhibits Thyroid Peroxidase
- PTU Blocks Peripheral Conversion of T4 to T3
- Side Effects
- Agranulocytosis
- Skin Rash
- Hepatotoxicity (PTU)
- Teratogen (MMI)
1 min
Amiodarone
- Mechanisms
- Class III Antiarrhythmic (K+ Channel Blocker)
- Decreases SA and AV Node Conduction
- Inhibits Cytochrome P450
- Indications
- Supraventricular Tachycardia with Heart Failure
- Ventricular Tachycardia
- Side Effects
- Hepatotoxicity
- Pulmonary Fibrosis
- Bradycardia
- Heart Block
- Thyroid Disorders
- Blue/Gray Skin Deposits
- Corneal Deposits
3 mins
Lithium
- Indications
- Bipolar Disorder
- Mechanism of Action
- Mood Stabilizer
- Unknown Mechanism
- Side Effects
- Nephrogenic Diabetes Insipidus
- Hypothyroidism
- Movement (Tremor)
- Heart Block
- Contraindication
- Pregnancy (Ebstein's Anomaly)
1 min
Leuprolide
- Mechanism
- GnRH Agonist (Pulsatile Use)
- GnRH Antagonist (Continuous Use)
- Upregulates FSH And LH
- Downregulates FSH And LH
- Indications Pulsatile
- Infertility
- Indications Continuous
- Prostate Cancer
- Precocious Puberty
- Uterine Fibroids
- Endometriosis
- Side Effects
- Anti-androgenic Effects
2 mins
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