Amy Shared "Analgesics and antidotes" - 12 Picmonics

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Analgesics and antidotes

Opioids Overview
Indications
Pain
Weaning
Cough
Diarrhea
Mechanism of Action
Agonists at Mu (μ), Kappa (Κ), and Delta (δ) Receptors
Decrease Synaptic Transmission
Side Effects
Respiratory Depression
Addiction
Miosis
Constipation
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2 mins
Opioid Antidote
Antidote
Naloxone
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28 secs
Morphine
Mechanism
Opioid Receptor Agonist
Indications
Pain
Myocardial Infarction
Side Effects
Nausea and Vomiting
CNS Depression
Biliary Colic
Constipation
Increased Intracranial Pressure (ICP)
Pupillary Constriction
Hypotension
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2 mins
Tramadol
Indications
Chronic Pain
Mechanism of Action
Weak Opioid
Inhibit Serotonin and NE reuptake
Side Effect
Increased Risk of Seizure
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47 secs
Codeine
Mechanism
Opioid Receptor Agonist
Indications
Mild to Moderate Pain
Cough Suppressant
Side Effects
Sedation
Constipation
Miosis
Considerations
Close Monitoring When Breast Feeding
Often Combined with Non-Opioids
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2 mins
Meperidine (Demerol)
Mechanism
Opioid Receptor Agonist
Indications
Moderate to Severe Pain
Post Anesthesia Shivering
Side Effects
Tremors
Constipation
CNS Depression
Sedation
Considerations
Short Term Administration
Increased Risk Serotonin Syndrome
Does NOT cause Miosis
Renal Failure Increases Toxicity Risk
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2 mins
Butorphanol
Indications
Migraine
Severe Pain
Labor
Mechanism of Action
Partial Agonist at Mu and Full Agonist at Kappa Receptors
Less Respiratory Depression
Side Effects
Withdrawal Symptoms
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1 min
Naloxone (Narcan)
Mechanism
Competitive Opioid Receptor Antagonist
Indications
Opioid Induced CNS Depression
Side Effects
Severe Nausea and Vomiting
Excitable State
Opioid Withdrawal Symptoms
Considerations
Repeated Dosing Often Required
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1 min
Fentanyl, Methadone, and Oxycodone
Mechanism of Action
Mu-opioid receptor agonist (C)
Fentanyl
Fentanyl
Highly lipid-soluble (C)
Strong agonist (C)
Severe analgesia after identification of dose level via other opioid (e.g., morphine) (C)
Intraspinal administration possible (C)
Do not change dose more than 1/week (long half-life) (C)
IV, transdermal (C)
Methadone
Methadone (C)
Chronic, severe pain (C)
Treatment of heroin and opioid addicts (C)
90% bound to plasma protein (C)
Accumulates in tissues (thus, extended duration of action) (C)
Do not change dose more than 1/week (long half-life) (C)
Oxycodone
Oxycodone
Moderate to severe analgesia (C)
Extended Release (C)
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Hydromorphone
Complications
Respiratory Depression
Hypotension
Urinary Retention
Constipation
Contraindications
Allergy to Acetaminophen
Paralytic Illius
Interactions
CNS Depressants
No MAO-Is
Common Name
Dialaudid
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Acetaminophen Antidote
Antidote
N-Acetylcysteine
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33 secs
Lidocaine
Mechanism
Blocks Na+ Channels
Indications
Ventricular Arrhythmia
Anesthetic
Side Effects
Paresthesias
Seizures
Respiratory Depression
Drowsiness
Consideration
Anesthetic Effects Extended with Epinephrine
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1 min

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