Rikki Shared "MSD E2 Pharm" - 33 Picmonics
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MSD E2 Pharm
Aspirin
- Indications
- Fever
- Pain and Headache
- Cardiovascular Disease (CAD)
- Mechanism of Action
- Irreversible inhibition of COX-1 and COX-2
- Suppress Thromboxanes and Prostaglandins
- NSAID
- Side Effects
- Reye's Syndrome
- Tinnitus
- Peptic Ulceration
- Mixed Acidosis/Alkalosis
- Nephropathy
2 mins
Ibuprofen (Advil, Motrin)
- Mechanisms
- NSAID
- COX Inhibitor
- Indications
- General Pain
- Fever
- Inflammatory Conditions
- Side Effects
- GI Ulcers
- Nephrotoxicity
- Rash
- Considerations
- Avoid with Alcohol
- Risk of Thrombotic Event
2 mins
NSAIDs
- Indications
- Anti-inflammatory
- Analgesic
- Fever
- Closure of Patent Ductus Arteriosus
- Mechanism of Action
- Reversible Inhibition of COX-1 and COX-2
- Block Prostaglandin Synthesis
- Side Effects
- Interstitial Nephritis
- Gastric Ulcer
- Renal Ischemia
1 min
Gout Treatment
- Acute (Acute-angle)
- NSAIDs
- Glucocorticoids
- Colchicine
- Impairs Leukocyte Chemotaxis
- Chronic Gout (Crone Goat)
- Inhibit Xanthine Oxidase
- Allopurinol
- Febuxostat
- Inhibit Reabsorption of Uric Acid
- Probenecid
1 min
Celecoxib
- Indications
- Rheumatoid Arthritis
- Osteoarthritis
- Pain
- Mechanism of Action
- NSAID
- Selectively Inhibits COX-2
- Side Effects
- Sulfa Allergy
- Increased Risk of Thrombosis
- GI Bleed
- Contraindication
- Pregnancy > 30 Weeks
1 min
Opioids Overview
- Indications
- Pain
- Weaning
- Cough
- Diarrhea
- Mechanism of Action
- Agonists at Mu (μ), Kappa (Κ), and Delta (δ) Receptors
- Decrease Synaptic Transmission
- Side Effects
- Respiratory Depression
- Addiction
- Miosis
- Constipation
2 mins
Codeine
- Mechanism
- Opioid Receptor Agonist
- Indications
- Mild to Moderate Pain
- Cough Suppressant
- Side Effects
- Sedation
- Constipation
- Miosis
- Considerations
- Close Monitoring When Breast Feeding
- Often Combined with Non-Opioids
2 mins
Butorphanol
- Indications
- Migraine
- Severe Pain
- Labor
- Mechanism of Action
- Partial Agonist at Mu and Full Agonist at Kappa Receptors
- Less Respiratory Depression
- Side Effects
- Withdrawal Symptoms
1 min
Naloxone (Narcan)
- Mechanism
- Competitive Opioid Receptor Antagonist
- Indications
- Opioid Induced CNS Depression
- Side Effects
- Severe Nausea and Vomiting
- Excitable State
- Opioid Withdrawal Symptoms
- Considerations
- Repeated Dosing Often Required
1 min
Morphine
- Mechanism
- Opioid Receptor Agonist
- Indications
- Pain
- Myocardial Infarction
- Side Effects
- Nausea and Vomiting
- CNS Depression
- Biliary Colic
- Constipation
- Increased Intracranial Pressure (ICP)
- Pupillary Constriction
- Hypotension
2 mins
Fentanyl
- Mechanism of Action
- Opioid Receptor Agonist
- High Potency
- Indications
- Anesthesia Induction
- Chronic Pain
- Breakthrough Pain
- Side Effects
- CNS Depression
- Respiratory Depression
- Constipation
- Miosis
- Considerations
- Addiction
3 mins
Dextromethorphan
- Mechanism
- Codeine Analog
- Weak Opioid
- NMDA Receptor Antagonist
- Uses
- Cough Suppressant
- Adverse Effects
- Serotonin Syndrome
- Drug Overdose
- Naloxone
2 mins
Succinylcholine
- Indications
- Inducing Paralysis
- Mechanism of Action
- Neuromuscular Blocking Drugs
- Motor Nicotinic Receptor
- ACh Receptor Agonist
- Depolarization
- Phases of Action
- Phase I (Paralysis Non-reversible)
- Phase II (Paralysis Reversible)
- Neostigmine (Reversal Agent)
2 mins
Tramadol
- Indications
- Chronic Pain
- Mechanism of Action
- Weak Opioid
- Inhibit Serotonin and NE reuptake
- Side Effect
- Increased Risk of Seizure
48 secs
Buprenorphine-Naloxone (Suboxone)
- Mechanism of Action
- Combination Drug
- Partial Opioid Receptor Agonist (Buprenorphine)
- Opioid Receptor Antagonist (Naloxone)
- Indication
- Opioid Use Disorder
- Side Effects
- CNS Depression
- Diaphoresis
- Hypotension
- Considerations
- Low Abuse Potential
2 mins
Oxycodone
- Mechanism of Action
- Opioid Receptor Agonist
- Indication
- Refractory Pain
- Side Effects
- Respiratory Depression
- Constipation
- CNS Depression
- Considerations
- Addiction
- Naloxone
2 mins
Meperidine (Demerol)
- Mechanism
- Opioid Receptor Agonist
- Indications
- Moderate to Severe Pain
- Post Anesthesia Shivering
- Side Effects
- Tremors
- Constipation
- CNS Depression
- Sedation
- Considerations
- Short Term Administration
- Increased Risk Serotonin Syndrome
- Does NOT cause Miosis
- Renal Failure Increases Toxicity Risk
2 mins
Etoposide
- Indications
- Small Cell Lung Cancer
- Testicular Cancer
- Mechanism of Action
- Inhibits Topoisomerase II
- Errors in DNA Synthesis Cause Apoptosis
- Side Effects
- Myelosuppression
- Alopecia
- Hypotension
- Nausea and Vomiting
2 mins
Doxorubicin (Adriamycin)
- Indications
- Solid Tumors
- Lymphomas and Leukemias
- Mechanism
- Free Radical Production
- Intercalates DNA
- Prevents Double Helix from Sealing
- Side Effect
- Cardiotoxicity
- Dexrazoxane Decreases Toxicity
1 min
Vitamin A (Retinol) Function and Deficiency
- Mechanism
- Retinol
- Constituent of Visual Pigments
- Differentiation of Epithelial Cells into Specialized Tissue
- Signs and Symptoms
- Night Blindness
- Dry Skin
- Considerations
- Used to Treat Measles
- Antioxidant
2 mins
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