Wayne Shared "Pathology Bliss 6/15/2024" - 53 Picmonics
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Pathology Bliss 6/15/2024
Henoch-Schonlein Purpura
- Most Common Childhood Vasculitis
- Follows Pharyngeal or Respiratory Infection
- Palpable Purpura on Legs and Buttocks
- Arthralgia
- Intestinal Hemorrhage
- Black Stool (Melena)
- Associated with IgA Nephropathy
2 mins
Berger's Disease (IgA Nephropathy)
- Nephritic
- IgA Nephropathy
- Immune Complex Deposit in Mesangium
- Increased Synthesis of IgA
- Most Common Cause of Nephritic Syndrome
- Overlapping Features with Henoch–Schönlein Purpura
- Presents with Pharyngitis, URI or Acute Gastroenteritis
1 min
Membranoproliferative Glomerulonephritis
- Nephritic-Nephrotic Syndrome
- Type I
- Subendothelial Immune Complexes
- Hepatitis C Virus
- Granular IF
- Tram Tracks Caused by Splitting of the GBM
- Ingrowth of Mesangium
- Type II
- Dense Deposit Disease
- C3 Nephritic Factor
2 mins
Celiac Disease Characteristics
- Epidemiology
- European Descent
- HLA-DQ2
- HLA-DQ8
- Pathophysiology
- Autoimmune-mediated Intolerance of Gliadin
- Symptoms
- Dermatitis Herpetiformis
- Weight Loss
- Failure to Thrive
- Decreased Bone Density
- Steatorrhea
- Anemia
2 mins
Post Streptococcal Glomerulonephritis
- Pathophysiology
- Nephritic
- Children
- Signs and Symptoms
- Edema
- Cola Colored Urine
- Follows Group A Streptococcal pharyngitis or Skin Infection
- Diagnosis
- Neutrophils
- Immunofluorescence (IF) Granular
- Lumpy Bumpy Appearance on Immunofluorescence (IF)
- Subepithelial Immune Complex Humps
2 mins
Rapidly Progressive Glomerulonephritis
- Pathogenesis
- Nephritic Syndrome
- Crescent Shape
- Crescents Consist of Fibrin and C3b
- With Parietal Cells, Monocytes, and Macrophages
- IMMUNOFLUORESCENCE
- Linear Immunofluorescence
- Negative Immunofluorescence
- Granular Immunofluorescence
- Etiology
- Goodpasture Syndrome
- Granulomatosis with Polyangiitis (Formerly Wegener's)
- Microscopic Polyangiitis
- Prognosis
- Poor Prognosis
3 mins
Alport Syndrome
- Pathophysiology
- Nephritic
- X-linked
- Mutation in Type IV Collagen
- Diagnosis
- Split Basement Membrane
- Basket Weave Appearance
- Signs and Symptoms
- Ocular Disorders
- Deafness
2 mins
Membranous Glomerulonephritis
- Characteristics
- Nephrotic
- Diagnosis
- LM Thickening of Capillary and Glomerular Basement Membrane (GBM)
- EM Spike and Dome Appearance with Subepithelial Deposits
- IF Granular
- Primary
- Phospholipase A2 Receptor Autoantibodies
- Secondary
- NSAIDS
- Gold
- Solid Tumors
- Hepatitis B Virus (HBV)
- Lupus
3 mins
Minimal Change Disease
- Pathophysiology
- Nephrotic
- Most Common in Children
- May be Triggered by Recent Infection or Immune Stimulus
- Diagnosis
- On Electron Microscopy (EM) See Foot Process (Podocyte) Effacement
- On Light Microscopy (LM) See Normal Glomeruli
- Loss of Negative Charge
- Selective Loss of Albumin
- Treatment
- Responds to Corticosteroids
2 mins
Diabetic Glomerulonephropathy
- Pathophysiology
- Nonenzymatic Glycosylation of Glomerular Basement Membrane
- Nonenzymatic Glycosylation of Arterioles
- Hyperfiltration
- Increased GFR
- Histological Findings
- Hyaline Arteriolosclerosis
- Mesangial Expansion
- Type IV Collagen Deposition
- Kimmelstiel Wilson Lesions
- Presentation
- Nephrotic
2 mins
Diffuse Proliferative Glomerulonephritis (DPGN)
- Nephritic and Nephrotic Syndrome
- Associations
- Systemic Lupus Erythematosus (SLE)
- IgA Nephropathy
- Characteristics
- Wire Looping
- IF Granular
- Subendothelial Immune Complexes
- Subepithelial Immune Complexes
- C3 Deposition
- Treatment
- Treat Underlying Disorder
- Steroids
2 mins
Prerenal Acute Kidney Injury Pathophysiology and Presentation
- Pathophysiology
- Decreased Renal Perfusion
- Decreased GFR
- Increased Sodium and Water Reabsorption
- Presentation
- Edema
- Dyspnea
- Hypotension with Tachycardia
- Altered Mental Status
- Oliguria
- Etiologies
- NSAIDs
- Renal Artery Stenosis
- ACE Inhibitors
2 mins
Chronic Kidney Disease Early Symptoms Assessment
- Characteristics
- GFR < 60mL/min
- Accumulation of Waste Products
- Clinical Features
- General Malaise
- Hypertension
- Proteinuria
- Hyperkalemia
- Mineral and Bone Disorders
- Neuropathy
2 mins
Acute Tubular Necrosis
- ETIOLOGY
- Ischemic Injury
- Nephrotoxic Injury
- HISTOLOGY
- Granular Muddy Brown Casts
- Signs & Symptoms
- Intrinsic Renal Failure
- Oliguric Phase
- Metabolic Acidosis
- Hyperkalemia
- Increase in BUN and Creatinine
- Polyuria Phase
- Decrease in BUN and Creatinine
- Hypokalemia
- Treatment
- Supportive Care
3 mins
Chronic Kidney Disease Late Symptoms Assessment
- Metabolic Acidosis
- Severe Uremia
- Arrhythmias
- Edema
- CNS Depression
- Anemia
- Oliguria
- Pruritus
- Considerations
- End Stage Renal Disease (ESRD)
- GFR < 15mL/min
2 mins
Chronic Kidney Disease Interventions
- Interventions
- Daily Weights
- Strict I/O
- Renal Diet
- Strict Medication Regimen
- Erythropoietin
- Manage Hyperkalemia
- Manage CKD-MBD
- Dialysis
- Kidney Transplant
2 mins
Renal Osteodystrophy
- Pathophysiology
- Chronic Kidney Disease
- Secondary Hyperparathyroidism
- Hyperphosphatemia
- Hypocalcemia
- Decreased Calcitriol
- Clinical Features
- Osteitis Fibrosa Cystica
- Osteoporosis
- Osteomalacia
- Management
- Treating Underlying Disorder
2 mins
Prerenal Acute Kidney Injury Diagnosis and Management
- Diagnostic Findings
- BUN:Creatinine Ratio > 20:1
- Fractional Excretion of Sodium (FENa) < 1%
- Urine Osmolality > 500 mOsm/kg
- Hyaline Casts
- Management
- Fluid Replacement
- Monitor Renal Function
- Diuretics
2 mins
Postrenal Acute Kidney Injury Pathophysiology and Presentation
- Pathophysiology
- Bilateral Outflow Obstruction
- Decreased GFR
- Etiologies
- Benign Prostatic Hyperplasia (BPH)
- Nephrolithiasis
- Neoplasm
- Neurogenic Bladder
- Presentation
- Bladder Distension
- Lower Abdominal Pain
- Edema
- Oliguria
3 mins
Post Renal Acute Kidney Injury (AKI) Diagnosis and Management
- Diagnosis
- Physical Examination
- BUN:Creatinine ratio of 20:1 in the Initial Stages
- BUN:Creatinine ratio of 10:1 in the late stages
- Urine Osmolality <350 mOsm/kg
- Variable Fractional Excretion of Sodium (FENa)
- Ultrasound
- CT Scan
- Management
- Treat Underlying Cause
4 mins
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