Warm Agglutinin Autoimmune Hemolytic Anemia (W-AIHA)
- Most Common Autoimmune Hemolytic Anemia
- IgG Coats RBCs at Warm Temperatures
- Fc Portion of IgG Recognized By Macrophages
- Extravascular Hemolysis
- Medications
- Alpha Methyldopa
- Chronic Lymphocytic Leukemia (CLL)
- Systemic Lupus Erythematosus (SLE)
- Positive Coombs Test
- Corticosteroids
- Splenectomy
- Intravenous Immunoglobulin (IVIG)
- Rituximab
Cold Agglutinin Autoimmune Hemolytic Anemia (C-AIHA)
- IgM Binds to RBCs at Cold Temperatures (28-31C)
- Extravascular Hemolysis
- Waldenstrom's Macroglobulinemia
- Mycoplasma Pneumoniae
- Infectious Mononucleosis
- Lymphomas and CLL
- Acrocyanosis with Cold Exposure
- Blue Fingers and Toes
- Positive Coombs Test
- Avoid Cold
- Rituximab
- +/- Fludarabine
Normocytic Hemolytic Anemia Causes
- Hereditary Spherocytosis
- RBC Enzyme Deficiency
- Hemoglobin C Defect
- Paroxysmal Nocturnal Hemoglobinuria (PNH)
- Sickle Cell Anemia
- Autoimmune
- Microangiopathic
- Mechanical Destruction
- Prosthetic Cardiac Valves
- Infection
- Snake Venom
Normocytic Nonhemolytic Anemia Causes
- MCV 80-100
- Anemia of Chronic Disease/Inflammation
- Aplastic Anemia
- Chronic Kidney Disease
- Early Iron Deficiency
Glanzmann Thrombasthenia
- Autosomal Recessive or Acquired as an Autoimmune Disorder
- Deficiency of Glycoprotein IIb/IIIa (Gp IIb/IIIa) Receptor
- Defective Platelet-to-Platelet Aggregation
- Mucous Membrane Bleeding (Gingival Bleeding)
- Easy Bruising
- Increased Bleeding Time
- Normal Platelet Count
- Avoid NSAIDs