Von Willebrand Disease
- Mixed platelet and coagulation disorder
- Autosomal Dominant Condition Leading to Reduced vWF
- Defect in platelet plug formation
- Increased Bleeding Time
- PTT increased
- Factor VIII decreased
- Normal platelet count
- DDAVP (synthetic vasopressin)
Disseminated Intravascular Coagulation (DIC)
- Bleeding state
- Activation of clotting factors
- Deficiency of clotting factors
- Sepsis
- Trauma
- Obstetric complications
- Acute Pancreatitis
- Malignancy
- Nephrotic Syndrome
- Transfusion
Factor V Leiden Thrombophilia
- Most Common Genetic Clotting Disorder in Caucasians
- Genetic Point Mutation
- Glutamine Replaces Arginine
- Mutant Factor V
- Resistant to Degradation by Activated Protein C
- Hypercoagulability
- Recurrent DVT (Increased Risk of Thromboembolism)
- Avoid Oral Contraceptives
- Caution During Pregnancy
Protein C or S Deficiency
- Autosomal Dominant
- Inability to Inactivate Factor Va and VIIIa
- Hypercoagulable State
- Recurrent DVTs or DVTs at Young Age
- Begin Heparin
- Slowly Bridge to Warfarin
- Hemorrhagic Skin Necrosis