Ace Your First Aid for the USMLE Step 1 (2021) Classes and Exams with Picmonic: #1 Visual Mnemonic Study Tool for Physician Assistant Students

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First Aid for the USMLE Step 1 (2021) | Physician Assistant School Study Aid


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Bernard-Soulier Syndrome
Mechanism
Autosomal Recessive
Deficiency of Glycoprotein Ib (GpIb) Receptor
Symptoms
Mucosal Membrane Bleeding
Menorrhagia
Easy Bruising
Labs
Large Platelets
Increased Bleeding Time
No Platelet Agglutination with Ristocetin
3 mins
Glanzmann Thrombasthenia
Pathophysiology
Autosomal Recessive or Acquired as an Autoimmune Disorder
Deficiency of Glycoprotein IIb/IIIa (Gp IIb/IIIa) Receptor
Defective Platelet-to-Platelet Aggregation
Symptoms
Mucous Membrane Bleeding (Gingival Bleeding)
Easy Bruising
Increased Bleeding Time
Normal Platelet Count
Considerations
Avoid NSAIDs
2 mins
Immune Thrombocytopenic Purpura
Features
Most Common Cause of Thrombocytopenia
IgG Against Platelet GPIIb/IIIa
Acute: Children After Viral Infection or Immunization
Chronic:  Women of Childbearing Age
Clinical Presentation
Bleeding
Petechiae
Isolated Thrombocytopenia
Diagnosis
Increased Megakaryocytes on Bone Marrow Biopsy
Diagnosis of Exclusion
Management
Corticosteroids
IVIG
Splenectomy in Refractory Cases
6 mins
Thrombotic Thrombocytopenic Purpura (TTP)
Inhibition or deficiency of ADAMTS 13
vWF Multimers are not degraded
Microthrombi (and Emboli)
Symptoms
FAT RN Pentad
Fever
Anemia
Thrombocytopenia
Renal Dysfunction
Neurologic Abnormalities (Altered Mental status)
Treatment
Plasmapheresis
Corticosteroids
Splenectomy
2 mins
Hemolytic Uremic Syndrome (HUS)
Children
Pathophysiology
Preceded by Acute Diarrheal Illness
Endothelial Damage
Classic Triad of Symptoms
Microangiopathic Hemolytic Anemia (MAHA)
Thrombocytopenia
Renal Failure
Labs
Helmet cells
LDH
Treatment
Dialysis
Supportive
2 mins

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