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Overview of Antineoplastic Agents

Pharmacotherapeutics for Advanced Nursing Practice, 1st. Ed., Demler & Rhoads, 2018

Chapter 3: Antineoplastic Agents

Cyclophosphamide

Mechanism

Requires Bioactivation by Liver

What mechanism of action or pharmacological action is best associated with Cyclophosphamide?

Cross-links DNA

Guanine N7 Position

Indications

Autoimmune Disorders

Which of the following is an indication for the use of Cyclophosphamide?

Leukemia

Lymphoma

Solid Tumors

Side Effects

Myelosuppression

During your assessment of a patient taking Cyclophosphamide which of the following side effects is most likely to be seen?

Hemorrhagic Cystitis

Prevent with Mesna

Which of the following points are important regarding prevention of side effects associated with Cyclophosphamide?

Pneumocystis jirovecii

Fungi

Pneumocystis jiroveci is most likely associated with which of the following types of pathogens?

AIDS/Immunocompromised

Which of the following groups of people are associated with Pneumocystis jiroveci?

Fever

During your assessment of a patient with Pneumocystis jiroveci which of the following is most likely to be seen?

Hypoxemia

Bronchoalveolar Lavage

Which of the following tests helps diagnose Pneumocystis jiroveci?

Biopsy

Methenamine Silver Stain

Which type of stain is most likely associated with Pneumocystis jiroveci?

Saucer/cup shaped yeast forms

Which microscopic finding or histological description is associated with Pneumocystis jiroveci?

Diffuse interstitial pneumonia CXR

During your assessment of a patient with Pneumocystis jiroveci which of the following imaging findings is most likely to be seen?

TMP-SMX

Which of the following medications is indicated as treatment & prophylaxis for Pneumocystis jiroveci?

Start prophylaxis when CD4 drops under 200

Which of the following is an important consideration regarding management of Pneumocystis jiroveci?

Busulfan

Which of the following is an indication for Busulfan?

Bone Marrow Ablation

What mechanism of action or pharmacological action is best associated with Busulfan?

Which of the following side effects would most likely be associated with Busulfan?

Pulmonary Fibrosis

Hyperpigmentation

DNA Agents

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Overview of Antineoplastic Agents - Chapter 3: Antineoplastic Agents - Pharmacotherapeutics for Advanced Nursing Practice, 1st. Ed., Demler & Rhoads, 2018 - DNA Agents for Nursing RN

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