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Pharmacotherapeutics for Advanced Nursing Practice, 1st. Ed., Demler & Rhoads, 2018 | Registered Nurse (RN) School Study Aid
Myelosuppression is Treated with Leucovorin Rescue (Folinic Acid)
Inhibits Ribonucleotide Reductase
Decreased DNA Synthesis
Chronic Myelogenous Leukemia (CML)
Sickle Cell Disease
Through Increased HbF (Fetal Hemoglobin)
Bone Marrow Ablation
Requires Bioactivation by Liver
Guanine N7 Position
Prevent with Mesna
GnRH Agonist (Pulsatile Use)
GnRH Antagonist (Continuous Use)
Upregulates FSH And LH
Downregulates FSH And LH
Mechanism of Action
Selective Estrogen Receptor Modulator (SERM)
Antagonist on Breast Tissue
ER-positive Breast Cancer
Decreased Risk of Osteoporosis
Increased Risk of Endometrial Cancer
Increased Risk of Venous Thromboembolism (VTE)
Chronic Lymphocytic Leukemia (CLL)
Microscopic Polyangiitis (MPA)
Wegener's (Granulomatosis with Polyangiitis)
Monoclonal Antibody Against CD20
Found on B Cell Neoplasms
Skin and Mouth Reactions
Reactivation of Hepatitis B Virus (HBV)
Progressive Multifocal Leukoencephalopathy (PML)
Nausea and Vomiting
Antiemetics Before Administration
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