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Methotrexate

Indications

Rheumatoid Arthritis

Which of the following is most likely an indication for methotrexate?

Cancer

Medical Abortion

Mechanism

Folic Acid Analog

Inhibits Dihydrofolate Reductase

What mechanism of action or pharmacological action is best associated with methotrexate?

Side Effects

Pulmonary Fibrosis

Which of the following side effects is most likely associated with methotrexate?

Myelosuppression is Treated with Leucovorin Rescue (Folinic Acid)

How is myelosuppression associated with methotrexate therapy reversed?

Macrocytic Anemia

Hepatitis

Teratogenic

What best describes a property of methotrexate?

Mucositis

Hydroxyurea

Inhibits Ribonucleotide Reductase

What mechanism of action or pharmacological action is best associated with Hydroxyurea?

Decreased DNA Synthesis

S-phase Specific

Melanoma

Hydroxyurea is most likely indicated for which of the following?

Chronic Myelogenous Leukemia (CML)

Sickle Cell Disease

Through Increased HbF (Fetal Hemoglobin)

Myelosuppression

During your assessment of a patient taking Hydroxyurea which of the following side effects is most likely to be seen?

GI Distress

Antimetabolite Agents

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Overview of Antineoplastic Agents - Chapter 3: Antineoplastic Agents - Pharmacotherapeutics for Advanced Nursing Practice, 1st. Ed., Demler & Rhoads, 2018 - Antimetabolite Agents for Nursing RN

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