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Pharmacology and the Nursing Process, 9th Ed., Lilley, Rainforth Collins & Snyder, 2019 | Registered Nurse (RN) School Study Aid
Histamine Dilates and Increases Capillary Permeability
Macrophages Engulf Pathogens
Macrophage Signals Cells With Cytokines
Responding Neutrophils Cross Capillary Wall
B And T Lymphocytes Arrive At Injury Site
Closure of PDA
Mechanism of Action
Reversible Inhibition of COX-1 and COX-2
Block Prostaglandin Synthesis
Aspirin (Acetylsalicylic Acid)
Inhibits Platelet Aggregation
Thrombotic Event Prevention
Withhold Before Surgery 7-10 Days
Aspirin Poisoning (Salicylism) Assessment
Nausea and Vomiting
Ibuprofen (Advil, Motrin)
Avoid with Alcohol
Risk of Thrombotic Event
Mechanism of Action
Selectively Inhibits COX-2
Increased Risk of Thrombosis
Pregnancy > 30 Weeks
Acute Inflammatory Monoarthritis
Primarily in Males
Precipitation of Monosodium Urate Crystals
Underexcretion of Uric Acid
Overproduction of Uric Acid
Negatively Birefringent, Needle-Shaped
Swollen, Red, Painful Joint
Asymmetric Joint Distribution
After Large Meal or Alcohol
Impairs Leukocyte Chemotaxis
Chronic Gout (Crone Goat)
Inhibit Xanthine Oxidase
Inhibit Reabsorption of Uric Acid
Aspirin (Salicylates) to Treat Viral Illness (In Children)
Lethargy (Decreased LOC)
Monitor for Increased ICP
No Aspirin for Children
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