NSAIDs
- Anti-inflammatory
- Analgesic
- Fever
- Closure of Patent Ductus Arteriosus
- Reversible Inhibition of COX-1 and COX-2
- Block Prostaglandin Synthesis
- Interstitial Nephritis
- Gastric Ulcer
- Renal Ischemia
Aspirin (Acetylsalicylic Acid)
- Inhibits Platelet Aggregation
- NSAID
- Thrombotic Event Prevention
- General Pain
- Inflammatory Conditions
- Fever
- Pancytopenia
- GI Ulcers
- Bleeding
- Withhold Before Surgery 7-10 Days
- Reye's Syndrome
Aspirin Poisoning (Salicylism) Assessment
- Nausea and Vomiting
- Tinnitus
- Confusion
- Hyperventilation
- Respiratory Alkalosis
- Metabolic Acidosis
- Coma
- Hyperthermia
Reye's Syndrome
- Aspirin (Salicylates) to Treat Viral Illness (In Children)
- Cerebral Edema
- Lethargy (Decreased LOC)
- Vomiting
- Liver Failure
- Monitor for Increased ICP
- Mannitol (Osmitrol)
- No Aspirin for Children
Ibuprofen (Advil, Motrin)
- NSAID
- COX Inhibitor
- General Pain
- Fever
- Inflammatory Conditions
- GI Ulcers
- Nephrotoxicity
- Rash
- Avoid with Alcohol
- Risk of Thrombotic Event
Prednisone (Glucocorticoids)
- Glucocorticoid
- Inflammatory Conditions
- Organ Transplant Rejection
- Cataracts and Glaucoma
- Cushing's Syndrome
- Osteoporosis
- Immunosuppression
- Hyperglycemia
- Ulcers
- Adrenal Insufficiency
- Taper Gradually
Acetaminophen
- Fever
- Pain
- Reversibly Inhibits COX
- Acts Primarily in CNS
- Hepatic Necrosis
- N-acetylcysteine Antidote
Celecoxib
- Rheumatoid Arthritis
- Osteoarthritis
- Pain
- NSAID
- Selectively Inhibits COX-2
- Sulfa Allergy
- Increased Risk of Thrombosis
- GI Bleed
- Pregnancy > 30 Weeks
Opioids Overview
- Pain
- Weaning
- Cough
- Diarrhea
- Agonists at Mu (μ), Kappa (Κ), and Delta (δ) Receptors
- Decrease Synaptic Transmission
- Respiratory Depression
- Addiction
- Miosis
- Constipation
Opioid Use Disorder and Withdrawal Assessment (Formerly Opioid Abuse and Withdrawal Assessment)
- Euphoria
- Miosis
- CNS Depression
- Yawning
- Gooseflesh
- Sweating
- Rhinorrhea
- Kicking Movements
- Naloxone
Codeine
- Opioid Receptor Agonist
- Mild to Moderate Pain
- Cough Suppressant
- Sedation
- Constipation
- Miosis
- Close Monitoring When Breast Feeding
- Often Combined with Non-Opioids
Morphine
- Opioid Receptor Agonist
- Pain
- Myocardial Infarction
- Nausea and Vomiting
- CNS Depression
- Biliary Colic
- Constipation
- Increased Intracranial Pressure (ICP)
- Pupillary Constriction
- Hypotension
Oxycodone
- Opioid Receptor Agonist
- Refractory Pain
- Respiratory Depression
- Constipation
- CNS Depression
- Addiction
- Naloxone
Acetaminophen-Hydrocodone (Vicodin)
- Combination Analgesic
- Opioid Receptor Agonist
- Hydrocodone
- Reversible Inhibition of COX
- Acetaminophen
- Moderate to Severe Pain
- CNS Depression
- Respiratory Depression
- Hepatotoxicity
- Addiction
Meperidine (Demerol)
- Opioid Receptor Agonist
- Moderate to Severe Pain
- Post Anesthesia Shivering
- Tremors
- Constipation
- CNS Depression
- Sedation
- Short Term Administration
- Increased Risk Serotonin Syndrome
- Does NOT cause Miosis
- Renal Failure Increases Toxicity Risk
Fentanyl
- Opioid Receptor Agonist
- High Potency
- Anesthesia Induction
- Chronic Pain
- Breakthrough Pain
- CNS Depression
- Respiratory Depression
- Constipation
- Miosis
- Addiction
IV Anesthetics
- Barbiturates
- Benzodiazepines
- Respiratory Depression
- Hypotension
- Ketamine
- NMDA Receptor Antagonist
- Hallucinations
- Opioids
- Propofol
- Potentiates GABA-A