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NCLEX-RN® Test Plan: Client Needs
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Adverse Effects/Contraindications/Side Effects/Interactions

Ace Your NCLEX-RN® Test Plan: Client Needs Classes and Exams with Picmonic: #1 Visual Mnemonic Study Tool for Registered Nurse (RN) Students

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NCLEX-RN® Test Plan: Client Needs | Registered Nurse (RN) School Study Aid

Adverse Effects/Contraindications/Side Effects/Interactions
291 Picmonics to Learn | 8 hrs 28 mins
Benzodiazepine Antidote
Antidote
Flumazenil
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40 secs
Warfarin Antidotes
Antidotes
Vitamin K
Fresh Frozen Plasma
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59 secs
Acetylcholinesterase Inhibitor Antidote
Antidote
Atropine
Pralidoxime
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1 min
Acetaminophen Antidote
Antidote
N-Acetylcysteine
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33 secs
Antimuscarinic Antidote
Antidote
Physostigmine Salicylate
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44 secs
Amphetamine Antidote
Antidote
Ammonium Chloride (NH4Cl)
Acidify Urine
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34 secs
Beta Blocker Antidote
Antidote
Glucagon
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29 secs
Arsenic, Gold and Copper Antidotes
Toxic Metals
Arsenic
Gold
Copper
Antidotes
Penicillamine
Dimercaprol (BAL)
Succimer
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2 mins
Iron Antidote
Antidote
DeFEroxamine
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23 secs
Opioid Antidote
Antidote
Naloxone
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29 secs
Tricyclic Antidepressant (TCA) Antidote
Antidote
Sodium Bicarbonate (NaHCO3)
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27 secs
Aspirin Poisoning (Salicylism) Assessment
Early Symptoms
Nausea and Vomiting
Tinnitus
Confusion
Hyperventilation
Respiratory Alkalosis
Late Symptoms
Metabolic Acidosis
Coma
Hyperthermia
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1 min
Lead Antidotes
Antidotes
Dimercaprol
CaEDTA
Succimer
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39 secs
Anticholinergics
B.O.AT.S Acronym
Benztropine
Parkinson's Disease
Oxybutynin
Decrease bladder spasms
Atropine
Mydriasis and Cycloplegia
Scopolamine
Motion Sickness
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1 min
Anticholinergics Continued
Drugs
Glycopyrrolate
Reduces Airway Secretions
Ulcer Treatment
Ipratropium
Asthma and C.O.P.D
Dicyclomine
Hyoscyamine
Irritable Bowel Syndrome
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1 min
Atropine
Mechanism of Action
Muscarinic Antagonist
Indications
Bradycardia
Increased Exocrine Secretions
Smooth Muscle Spasms
Side Effects
Tachycardia
Dry Mouth
Urinary Retention
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2 mins
Benztropine (Cogentin)
Mechanism
Anticholinergic
Indications
Parkinson's Disease
Acute Dystonia
Side Effects
Blurred Vision
Dry Mouth
Urinary Retention
Tachycardia
Constipation
Psychosis
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2 mins
Direct Cholinomimetics
Muscarinic Agonists
Bethanechol
Bladder and Bowels
Methacholine
Bronchoconstriction
Pilocarpine
Contracts Ciliary Muscle and Pupillary Sphincter
Carbachol
Releases Intraocular Pressure
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1 min
Indirect Cholinomimetics
Acetylcholinesterase Inhibitors
Doesn't Cross BBB
Edrophonium
Myasthenia Gravis (Diagnosis)
Pyridostigmine and Neostigmine
Myasthenia Gravis (Tx)
Ileus
Crosses BBB
Physostigmine
Atropine Overdose
Glaucoma
Donepezil
Alzheimer's
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2 mins
Pilocarpine (Pilocar)
Mechanism
Direct Cholinergic Agonist
Contracts Iris Sphincter
Contracts Ciliary Muscle
Indications
Xerostomia
Glaucoma
Side Effects
Detached Retina
Decreased Visual Acuity
Eye Irritation
Cholinergic Effects
Considerations
Avoid with Asthma or Bradycardia
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2 mins
Acetylcholinesterase Inhibitor Poisoning
DUMBBELSS
Diarrhea
Urination
Miosis
Bronchospasm
Bradycardia
Emesis
Lacrimation
Salivation
Sweating
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2 mins
Alpha Agonists
-RINE suffix
Norepinephrine
Hypotension
Phenylephrine
Hypotension
Congestion
Ephedrine
Congestion
Urinary Incontinence
Hypotension
Epinephrine
Anaphylaxis and Asthma
Hypotension
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1 min
Prazosin (Minipress)
-osin suffix
Mechanisms
Selective Alpha-1 Receptor Blocker
Indications
Hypertension
Benign Prostatic Hyperplasia (BPH)
Nightmares
Side Effects
Orthostatic Hypotension
Tachycardia
Priapism / Inhibition of Ejaculation
Nasal Congestion
Considerations
First Dose Effect
Administer at Bedtime
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2 mins
Beta Blockers
"-olol" suffix
Mechanism
Decreases Heart Rate and Contractility
Decreases Peripheral Vascular Resistance
Decreases Renin Release
Indications
Hypertension
Heart Failure
Angina Pectoris
Contraindications
Asthma and Heart Block Patients
Nursing Considerations
Assess Blood Pressure and Heart Rate
Masking Signs of Hypoglycemia
Do Not Stop Abruptly
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2 mins
Cardiovascular Effects of Beta-Blockers
Cardiac Myocytes and Vasculature
Decrease cAMP
Decreases SA and AV Node Conduction Velocity
Lower Blood Pressure
Decrease O2 Consumption
Decreases Mortality Post-MI
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2 mins
Systemic Effects of Beta-Blockers
Respiratory
Bronchoconstriction
Metabolic
Decreased Insulin
Decreased Glycolysis and Lipolysis
Eye
Reduces Intraocular Pressure
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1 min
Epinephrine (Adrenaline)
Mechanism
Alpha and Beta Agonist
Indications
Anaphylaxis
Primary Open Angle Glaucoma (POAG)
Bleeding
Cardiac Arrest
Side Effects
Tachycardia
Hypertension
Tremors
Insomnia
Considerations
Multiple Strengths
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2 mins
Ephedrine
Mechanism of Action
Alpha Agonist
Beta Agonist
Indications
Rhinitis
Hypotension
Urinary Incontinence
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35 secs
Norepinephrine (Levophed)
Mechanism of Action
Alpha Agonist
Beta-1 Agonist
Indications
Severe Hypotension
Side Effect
Decreases Renal Blood Flow
Arrhythmias
Hypertension
Considerations
Tissue Necrosis
Last Resort Medication
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2 mins
Dobutamine
Mechanism
Beta-1 Agonist
Inotropic
Indications
Heart Failure
Side Effects
Tachycardia
Arrhythmias
Considerations
Closely Monitor Patients
Other Meds May Increase Potency
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1 min
Selective Serotonin Reuptake Inhibitor (SSRI) Overview
Indications
Depression
Anxiety
Mechanism of Action
Selective Serotonin Reuptake Inhibitors
Drugs
Paroxetine
Sertraline
Escitalopram
Fluoxetine
Side Effects
Sexual Dysfunction
Serotonin Syndrome
Treat with Cyproheptadine
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2 mins
Fluoxetine (Prozac)
Mechanism of Action
Inhibits Reuptake of Serotonin
Indications
Depression
Side Effects
Sexual Dysfunction
CNS Stimulation
Weight Changes
Serotonin Syndrome
Contraindications
No MAO-Is
No Anticoagulants / Antiplatelets
Considerations
Suicide Risk
Delayed Onset of Action
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2 mins
Serotonin Norepinephrine Reuptake Inhibitors (SNRIs)
Indications
Depression
Diabetic Peripheral Neuropathy
Duloxetine
Panic and Anxiety
Venlafaxine
Mechanism of Action
Inhibits Reuptake of Serotonin and NE
Side Effects
Hypertension
Insomnia
Nausea and Vomiting
Decreased Libido
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1 min
Bupropion
Indications
Depression
Smoking Cessation
Mechanism of Action
Increase Dopamine and NE
Side Effects
Stimulant Side Effects
Seizure
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1 min
Tricyclic Antidepressants (TCAs)
Mechanism of Action
Inhibits Reuptake of Norepinephrine and Serotonin
Indications
Depression
Bipolar Disorder
Fibromyalgia
Side Effects
Sedation
Orthostatic Hypotension
Anticholinergic Effects
Cardiac Toxicity
Considerations
Delayed Effect
Do Not Stop Abruptly
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2 mins
Tricyclic Antidepressants (TCAs) Indications
Indications
Major Depression
Bedwetting
Fibromyalgia
OCD
Drugs
-Iptyline or -Ipramine Suffix
Amitriptyline
Desipramine
Clomipramine
Imipramine
Nortriptyline
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2 mins
Monoamine Oxidase Inhibitor (MAOI) Contraindications
Contraindications
Wine and Cheese
Hypertensive Crisis
Serotonin Drugs
Serotonin Syndrome
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1 min
Monoamine Oxidase Inhibitors (MAO-Is)
Indications
Atypical Depression
Mechanism of Action
Increase Levels of Amine Neurotransmitters
Drugs
"Takes Pride In Shanghai"
Tranylcypromine
Phenelzine
Isocarboxazid
Selegiline
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1 min
Aripiprazole (Abilify)
Mechanism
2nd Generation Atypical Antipsychotic
Indications
Schizophrenia
Bipolar Disorder
Depression
Side Effects
Headache
Dizziness
Nausea and Vomiting
Insomnia
Anxiety
Considerations
Low Risk of Extrapyramidal Symptoms
Lowest Risk of Weight Gain
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2 mins
Serotonin Syndrome Assessment
Mild Signs & Symptoms
Restlessness
Diaphoresis
Tachycardia
Hypertension
Diarrhea
Moderate Signs & Symptoms
Hyperthermia
Decreased Level of Consciousness
Muscle Rigidity
Severe Signs & Symptoms
Seizure and Coma
Treatment
Cyproheptadine
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2 mins
Vortioxetine
Mechanism of Action
Inhibits Reuptake of Serotonin
Indication
Major Depressive Disorder
Side Effects
Nausea
Sexual Dysfunction
Anticholinergic Effects
Sleep Disturbances
Considerations
Serotonin Syndrome
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2 mins
Antipsychotics Overview
Indications
Schizophrenia
Tourette's Syndrome
Mechanism of Action
Lipid-Soluble
Block Dopamine Receptors
Side Effects
Galactorrhea
Tardive Dyskinesia
Anticholinergic
Alpha1 Antagonist
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2 mins
Low Potency Antipsychotic Drugs
Drugs
Chlorpromazine
Corneal Deposits
Thioridazine
Retinal Deposits
Shared Side Effects
Alpha1 Antagonist Effects
Anticholinergic Effects
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51 secs
High Potency Antipsychotic Drugs
High Potency Drugs
Fluphenazine
Trifluoperazine
Haloperidol
Side Effects
Extrapyramidal Symptoms
Short Term
Dystonia
Torticollis
Long Term
Tardive Dyskinesia
Parkinson's-like Symptoms
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2 mins
Atypical Antipsychotics
Indications
Schizophrenia
Mechanism of Action
Unknown Mechanism
Side Effects
Seizures
Prolonged QT Interval
Agranulocytosis
Weight Gain
Fewer Extrapyramidal Side Effects
Fewer Anticholinergic Side Effects
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2 mins
Neuroleptic Malignant Syndrome
FEVER Acronym
Fever
Encephalopathy
Vital Signs Unstable
Elevated Enzymes
Rigidity of muscles
Reversal Agent
D2 Agonists
Bromocriptine
Dantrolene
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2 mins
Malignant Hyperthermia vs. Neuroleptic Malignant Syndrome vs. Serotonin Syndrome
Autonomic Instability
Muscle Rigidity
Malignant Hyperthermia
Ryanodine Receptor 1 Mutation
Inhaled Anesthetics
Succinylcholine
Dantrolene
Neuroleptic Malignant Syndrome
Antidopaminergic Medications
Hyporeflexia
Myoglobinuria
Dantrolene
Serotonin Syndrome
Serotonergic Medications
Hyperreflexia
Clonus
Cyproheptadine
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3 mins
Haloperidol (Haldol)
Mechanism
High Potency Antipsychotic
Indications
Migraine
Schizophrenia
Side Effects
Extrapyramidal Symptoms
Weight Gain
QT Prolongation
Restlessness
Considerations
Caution in Seizure Patients
Neuroleptic Malignant Syndrome
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2 mins
Chlorpromazine (Thorazine)
Mechanism
Low Potency Antipsychotic
Indications
Schizophrenia
Hiccups
Side Effects
Sedation
Weight Gain
Orthostatic Hypotension
Anticholinergic Effects
QT Prolongation
Neuroendocrine Effects
Caution in Seizure Patients
Corneal Deposits
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2 mins
Clozapine (Clozaril)
Mechanism
Atypical Antipsychotic
Indications
Schizophrenia
Levodopa-Induced Psychosis
Side Effects
Weight Gain
Hypersalivation (Sialorrhea)
Myocarditis
Agranulocytosis
Sedation
Orthostatic Hypotension
Constipation (Risk of Bowel Ileus)
Considerations
Weekly Lab Tests
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2 mins
Risperidone (Risperdal)
Mechanism
Atypical Antipsychotic
Indications
Schizophrenia
Bipolar Mania
Autism-Associated Irritability
Side Effects
Extrapyramidal Symptoms
Hyperprolactinemia
Gynecomastia
Galactorrhea
Amenorrhea
Prolonged QT
Considerations
Intramuscular Long Acting (Depot) Form
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2 mins
Lithium
Mechanism of Action
Mood Stabilizer
Unknown Mechanism
Indications
Bipolar Disorder
Side Effects
Nephrogenic Diabetes Insipidus
Hypothyroidism
Tremor
Heart Block
Contraindication
Pregnancy
Considerations
Monitor Plasma Levels
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2 mins
Triazolam (Halcion)
Mechanism
Rapid-Onset Benzodiazepine
Indications
Insomnia
Side Effects
Rebound Insomnia
Respiratory Depression
Hypotension
Paradoxical Excitement
Amnesia
Confusion
Contraindications
Pregnancy
Considerations
Short-Term Administration
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2 mins
Zolpidem (Ambien)
Mechanism
Hypnotic
Indications
Insomnia
Side Effects
Daytime Drowsiness
Bizarre Sleep Behaviors
Sleep Driving
Angioedema
Considerations
Short Term Administration
Take Immediately Before Bedtime
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1 min
Diazepam (Valium)
Indications
Anxiety
Seizures and Status Epilepticus
Muscle Spasms
Alcohol Withdrawal
Side Effect/Assessment
Dizziness/Vision Changes
Confusion/Amnesia
Urinary Incontinence
Behavioral Changes
Respiratory Depression
Antidote
Flumazenil (Romazicon)
Nursing Considerations
Fall Precaution
Do Not Stop Abruptly
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2 mins
Phenobarbital (Barbiturates)
Mechanism
Barbiturate
Indications
Seizures
Side Effects
Ataxia
Paradoxical Excitement
Fatigue/Drowsiness
Considerations
Monitor Plasma Levels
High Potential for Abuse
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1 min
Buspirone (Buspar)
Mechanism
Increases Serotonin
Indications
Anxiety
Side Effects
Dizziness
Insomnia
Considerations
Delayed Effect
Safer with Alcohol than Other Anxiolytics
Low Side Effect Profile
Low Abuse Potential
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1 min
Trazodone
Indications
Insomnia
Depression
Mechanism of Action
Inhibit Serotonin Reuptake
Alpha-1 Blocker
Histamine (H1) Blocker
Side Effects
Sedation
Orthostatic Hypotension
Dry Mouth
Priapism
Arrhythmias
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2 mins
Short-acting Benzodiazepines
Mnemonic
ATOM
Drug Names
Alprazolam
Triazolam
Oxazepam
Midazolam
Indications
Anesthesia Induction
Insomnia
Anxiety
Considerations
Half-life < 12 Hours
Dependence
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2 mins
Benzodiazepines Overview
Indications
First Line for Status Epilepticus
Anesthesia Induction
Anxiety
Eclampsia
Detoxification
Mechanism of Action
'-zepam' and '-zolam" Suffix
Increase Frequency of Cl- Channel Opening
Side Effects
Decrease REM Sleep
CNS Depression
Dependence
Antidote
Flumazenil for Overdose
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2 mins
Long-acting Benzodiazepines
Drug Names
Lorazepam
Diazepam
Clonazepam
Chlordiazepoxide
Indications
Insomnia
Anxiety
Seizures
Eclampsia
Alcohol Withdrawal
Considerations
Half-life > 24 Hours
Dependence
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3 mins
CNS Stimulants
Indications
Attention Deficit Hyperactivity Disorder (ADHD)
Obesity
Mechanism of Action
Increase Catecholamines at Synaptic Cleft
Increase Norepinephrine
Increase Dopamine
Drug Names
Methylphenidate (Ritalin)
Methamphetamine
Side Effect
Potential for Abuse
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57 secs
CNS Stimulant Indications
Drug Names
Amphetamine
Methylphenidate (Ritalin)
Mechanism of Action
Increased Norepinephrine
Increased Dopamine
Indications
Attention Deficit Hyperactivity Disorder (ADHD)
Obesity
Narcolepsy
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1 min
CNS Stimulant Side Effects
Side Effects
Agitation
Insomnia
Hypertension
Tachycardia
Tics
Anorexia
Considerations
Tolerance Develops
High Risk of Abuse and Dependence
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2 mins
Amphetamines Intoxication Assessment
Euphoria
Insomnia
Mydriasis
Diaphoresis
Hypertension
Tachycardia
Paranoia
Anxiety
Anorexia
Seizures
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2 mins
Cocaine Intoxication Assessment
Euphoria
Delusions
Mydriasis
Hallucinations
Agitation
Hypertension
Arrhythmias
Hyperthermia
Seizures
Nasal Septum Perforation
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2 mins
Local Anesthetic Overview
Indications
Minor Procedures
Epidurals
Mechanism of Action
Blocks Na+ Channels
State Dependent
Combined with Vasoconstrictors
Infected Tissue Requires Higher Dose
Drugs
Esters
Amides
Side Effects
Arrhythmias
Cardiotoxicity
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1 min
Inhaled Anesthetics
Mechanism of Action
Unknown Mechanism
Inhaled Anesthetic Drugs
HEISMN Drug Name Acronym
Side Effects
Respiratory Depression
Myocardial Depression
Lower Metabolic Demand, Increased Cerebral Blood Flow
Hepatotoxicity (Halothane)
Nephrotoxicity (Methoxyflurane)
Seizure (Enflurane)
Malignant Hyperthermia
Expansion of Trapped Gas
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2 mins
IV Anesthetics
Barbiturates
Benzodiazepines
Respiratory Depression
Hypotension
Ketamine
NMDA Receptor Antagonist
Hallucinations
Opioids
Propofol
Potentiates GABA-A
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2 mins
Lidocaine
Mechanism
Blocks Na+ Channels
Indications
Ventricular Arrhythmia
Anesthetic
Side Effects
Paresthesias
Seizures
Respiratory Depression
Drowsiness
Consideration
Anesthetic Effects Extended with Epinephrine
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1 min
Malignant Hyperthermia
Inheritance
Autosomal-Dominant
Pathophysiology and causes
Ryanodine Receptor 1 Mutation
Inhaled Anesthetics
Succinylcholine
Symptoms
Autonomic Instability
Muscle Rigidity
Treatment
Dantrolene
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2 mins
Lamotrigine (Lamictal)
Mechanism
Blocks Na+ Channels
Indications
Seizures
Bipolar Disorder
Side Effects
Diplopia
Stevens-Johnson Syndrome
Headache
Aseptic Meningitis
Nausea and Vomiting
Considerations
Screen for Suicide Risk
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2 mins
Phenytoin (Dilantin)
Mechanism
Blocks Na+ Channels
Indications
Tonic-clonic Seizures
Side Effects
Ataxia
Nystagmus
Sedation
Gingival Hyperplasia
Purple Glove Syndrome
Hirsutism
Rash
Anemia
Considerations
Individualized Dosing
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2 mins
Valproic Acid (Depakote)
Mechanism
Blocks Na+ Channels
Increases GABA Concentration
Indications
Tonic-clonic Seizures
Bipolar Disorder
Migraine Prophylaxis
Side Effects
Hepatotoxicity
Blood Dyscrasias
GI Distress
Tremor
Pancreatitis
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1 min
Carbamazepine (Tegretol)
Mechanism
Inactivates Na+ Channels
Indications
Seizures
Bipolar Disorder
Trigeminal Neuralgia
Side Effects
Nystagmus
Ataxia
Hepatotoxicity
Blood Dyscrasias
Water Retention
Stevens-Johnson Syndrome
Considerations
Avoid Grapefruit Juice
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2 mins
Ethosuximide (Zarontin)
Indications
First Line Absence Seizure
Mechanism of Action
Blocks Thalamic T-Type Ca2+ Channels
Side Effects
Stevens-Johnson Syndrome
Fatigue
Diarrhea
Blood Dyscrasias
Considerations
Do Not Stop Abruptly
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2 mins
Topiramate
Indications
Seizure Treatment
Migraine Prophylaxis
Mechanism of Action
Increase GABA Action
Blocks Voltage-Gated Na+ Channels
Side Effects
Kidney Stones
Weight Loss
Sedation
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1 min
Valproic Acid (Valproate) Side Effects
V-A-L-P-R-O-A-T-E
Vomiting
Alopecia
Liver Toxicity
Pancreatitis/Pancytopenia
Retain Fat (Weight Gain)
Oedema (Edema)
Appetite Increase
Tremor
Enzyme Inhibitor (P450)
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2 mins
Pregabalin (Lyrica)
Mechanism
GABA Analog
Indications
Seizures
Neuropathic Pain
Fibromyalgia
Side Effects
Headache
Dizziness
Somnolence (Fatigue)
Weight Gain
Angioedema
Rhabdomyolysis
Considerations
Dependence
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1 min
Nondepolarizing Neuromuscular Blocking Drugs
Names Include "Cur"
Competitive Antagonists
Acetylcholine Competition
Reversal of Blockade
Neostigmine, Edrophonium
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1 min
Succinylcholine
Indications
Inducing Paralysis
Mechanism of Action
Neuromuscular Blocking Drugs
Motor Nicotinic Receptor
ACh Receptor Agonist
Depolarization
Phases of Action
Phase I (Paralysis Non-reversible)
Phase II (Paralysis Reversible)
Neostigmine (Reversal Agent)
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2 mins
Parkinson's Drugs
Parkinsons Characteristics
Decreased Dopamine
Increased Acetylcholine
Drug Names
BALSA Acronym
Bromocriptine
Amantadine
Levodopa
Selegiline
Antimuscarinics
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2 mins
Levodopa/Carbidopa (Sinemet)
Mechanism
Increases Dopamine in Brain
Indications
Parkinson's Disease
Side Effects
Nausea and Vomiting
Arrhythmias
Dyskinesia
Psychosis
Orthostatic Hypotension
Considerations
Report Uncontrolled Movements
Darkened Sweat or Urine
Off and On Phenomenon
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2 mins
Memantine
Indications
Alzheimer's Disease
Mechanism of Action
NMDA Receptor Antagonist
Prevents Excitotoxicity
Side Effects
Confusion
Hallucinations
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1 min
Donepezil
Indications
Alzheimer's Disease
Mechanism of Action
Acetylcholinesterase Inhibitor
Increased Acetylcholine
Side Effects
Nausea and Vomiting
Dizziness
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52 secs
Sumatriptan
Mechanism of Action
Short Half-Life
5-HT Agonist
Inhibits Trigeminal Nerve Activation
Induces Vasoconstriction
Indications
Migraine
Cluster Headache
Side Effects
Increased Risk of Serotonin Syndrome
Paresthesias
Coronary Vasospasm
Contraindication
Prinzmetal's Angina
Coronary Artery Disease (CAD)
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3 mins
Gabapentin
Primary Indication
Seizure Treatment
Secondary Indications
Peripheral Neuropathy
Postherpetic Neuralgia
Bipolar Disorder
Migraine Prophylaxis
Characteristics
Inhibits Voltage-Gated Ca2+ channels
Designed as a GABA Analog
Side Effects
Ataxia
Sedation
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2 mins
Codeine
Mechanism
Opioid Receptor Agonist
Indications
Mild to Moderate Pain
Cough Suppressant
Side Effects
Sedation
Constipation
Miosis
Considerations
Close Monitoring When Breast Feeding
Often Combined with Non-Opioids
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2 mins
Morphine
Mechanism
Opioid Receptor Agonist
Indications
Pain
Myocardial Infarction
Side Effects
Nausea and Vomiting
CNS Depression
Biliary Colic
Constipation
Increased Intracranial Pressure (ICP)
Pupillary Constriction
Hypotension
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2 mins
Meperidine (Demerol)
Mechanism
Opioid Receptor Agonist
Indications
Moderate to Severe Pain
Post Anesthesia Shivering
Side Effects
Tremors
Constipation
CNS Depression
Sedation
Considerations
Short Term Administration
Increased Risk Serotonin Syndrome
Does NOT cause Miosis
Renal Failure Increases Toxicity Risk
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2 mins
Naloxone (Narcan)
Mechanism
Competitive Opioid Receptor Antagonist
Indications
Opioid Induced CNS Depression
Side Effects
Severe Nausea and Vomiting
Excitable State
Opioid Withdrawal Symptoms
Considerations
Repeated Dosing Often Required
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1 min
Tramadol
Indications
Chronic Pain
Mechanism of Action
Weak Opioid
Inhibit Serotonin and NE reuptake
Side Effect
Increased Risk of Seizure
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48 secs
Butorphanol
Indications
Migraine
Severe Pain
Labor
Mechanism of Action
Partial Agonist at Mu and Full Agonist at Kappa Receptors
Less Respiratory Depression
Side Effects
Withdrawal Symptoms
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1 min
Acetaminophen-Hydrocodone (Vicodin)
Mechanism of Action
Combination Analgesic
Opioid Receptor Agonist
Hydrocodone
Reversible Inhibition of COX
Acetaminophen
Indication
Moderate to Severe Pain
Side Effects
CNS Depression
Respiratory Depression
Hepatotoxicity
Considerations
Addiction
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2 mins
Oxycodone
Mechanism of Action
Opioid Receptor Agonist
Indication
Refractory Pain
Side Effects
Respiratory Depression
Constipation
CNS Depression
Considerations
Addiction
Naloxone
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2 mins
Suvorexant
Mechanism of Action
Orexin Receptor Antagonist
Indications
Insomnia
Side Effects
CNS Depression
Headache
Abnormal Dreams
Considerations
Contraindicated in Narcolepsy
Avoid in Liver Disease
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1 min
Fentanyl
Mechanism of Action
Opioid Receptor Agonist
High Potency
Indications
Anesthesia Induction
Chronic Pain
Breakthrough Pain
Side Effects
CNS Depression
Respiratory Depression
Constipation
Miosis
Considerations
Addiction
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3 mins
Buprenorphine-Naloxone (Suboxone)
Mechanism of Action
Combination Drug
Partial Opioid Receptor Agonist (Buprenorphine)
Opioid Receptor Antagonist (Naloxone)
Indication
Opioid Use Disorder
Side Effects
CNS Depression
Diaphoresis
Hypotension
Considerations
Low Abuse Potential
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2 mins
Acetazolamide
Indications
Glaucoma
Altitude Sickness
Pseudotumor Cerebri
CHF
Metabolic Alkalosis
Mechanism of Action
Carbonic Anhydrase Inhibitor
Sodium Bicarbonate (NaHCO3) Diuresis
Side Effects
Metabolic Acidosis
Paresthesias
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1 min
Hypertension Medications
Diuretics
ACE Inhibitors
Angiotensin Receptor Blockers (ARBs)
Beta Blockers
Dihydropyridine Calcium Channel Blockers
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2 mins
Angiotensin-Converting Enzyme (ACE) Inhibitors
"-pril" Suffix
Mechanism of Action
Block Renin Angiotensin-Aldosterone System (RAAS)
Indications
Hypertension
Heart Failure
Side Effects
Dry Non-productive Cough
Hypotension
Dizziness
Possible Hyperkalemia
Angioedema
Nursing Considerations
Slowly Change Position
Do Not Stop Abruptly
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2 mins
Angiotensin II Receptor Blockers (ARBs)
Ends in "-sartan"
Mechanism of Action
Blocks Angiotensin II Receptor
Indications
Hypertension
Side Effects
Angioedema
Contraindications
Renal Artery Stenosis
Pregnancy
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1 min
Hydralazine (Apresoline)
Indications
Severe Hypertension
CHF
Reduced Afterload
Pregnancy
Mechanism of Action
Vasodilates Arterioles
Side Effects
Drug-induced Lupus
Reflex Tachycardia
Hypotension
Considerations
Combined with Diuretic and Beta Blocker
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1 min
Minoxidil (Loniten, Rogaine)
Mechanism
Vasodilates Arterioles
Indications
Severe Hypertension
Baldness
Side Effects
Reflex Tachycardia
Blood Volume Expansion
Hypertrichosis
Pericardial Effusion
Rash
Considerations
Give with Beta Blocker and Diuretic
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2 mins
Nitroglycerin
Mechanism of Action
Decreases Preload
Indications
Angina
Up to 3 doses q 5 mins
Side Effects
Headache
Hypotension
Contraindications
Viagra (Sildenafil)
Nursing Considerations
Assess Blood Pressure
Protect From Light
Use Glass Bottle and Special Tubing
Gloves for Applying Topically
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2 mins
Sodium Nitroprusside (Nitropress)
Mechanism
Venous and Arterial Dilation
Indications
Hypertensive Crisis
Side Effects
Cyanide Toxicity
Thiocyanate Toxicity
Hypotension
Considerations
Short Term Administration
Light Sensitive, Use Container
Continuous BP Monitoring
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2 mins
K+ Sparing Diuretics
Indications
CHF and Hypertension
Hypokalemia
Hyperaldosteronism
Mechanism of Action
Collecting Tubule
Spironolactone
Competitive Aldosterone Receptor Antagonist
Amiloride and Triamterene
Block Na+ Channels
Side Effects
Hyperkalemia
Gynecomastia
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2 mins
Clonidine
Mechanism of Action
Alpha-2 Agonist
Indication
Hypertensive Urgency
Attention Deficit Hyperactivity Disorder (ADHD)
Tourette Syndrome
Opioid Withdrawal
Side Effects
CNS Depression
Respiratory Depression
Hypotension
Considerations
Rebound Hypertension if Abrupt Cessation
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2 mins
Adenosine (Adenocard)
Mechanism
Slows AV Conduction
Indications
Supraventricular Tachycardia (Paroxysmal)
Side Effects
Bradycardia
Flushing
Dyspnea
Considerations
Rapid IV Push
Caffeine and Theophylline Decrease Effectiveness
Dipyridamole May Intensify Effects
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2 mins
Magnesium Sulfate
Mechanism
Muscle Relaxant
Indications
Preterm Labor Contractions
Preeclampsia
Side Effects
Warm Feeling
Hypotension
Decreased Deep Tendon Reflexes (DTRS)
Decreased Respiratory Rate
Decreased Urine Output
Paralytic Ileus
Antidote
Calcium Gluconate
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2 mins
Calcium Channel Blockers (Verapamil and Diltiazem)
Mechanism of Action
Slows AV Conduction
Indications
Angina Pectoris
Arrhythmias
Essential Hypertension
Side Effects
Bradycardia
Hypotension
Constipation
Peripheral Edema
Gingival Hyperplasia
Nursing Consideration
Medication Education
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2 mins
Amiodarone
Mechanisms
Class III Antiarrhythmic (K+ Channel Blocker)
Decreases SA and AV Node Conduction
Inhibits Cytochrome P450
Indications
Supraventricular Tachycardia with Heart Failure
Ventricular Tachycardia
Side Effects
Hepatotoxicity
Pulmonary Fibrosis
Bradycardia
Heart Block
Thyroid Disorders
Blue/Gray Skin Deposits
Corneal Deposits
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3 mins
Digoxin (Lanoxin)
Mechanism of Action
Increases Inotropy
Indications
Heart Failure
Atrial Fibrillation
Side Effects
Bradycardia
Fatigue
Contraindications
Heart Block
Nursing Considerations
Heart Rate Below 60
Hypokalemia
Monitor for Toxicity and Visual Changes
Digibind
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2 mins
Acute Digoxin Toxicity
Clinical Symptoms
Hyperkalemia
Cholinergic (Nausea, Vomiting, Diarrhea)
Blurry Yellow Green Vision with Halo of Light
Arrhythmia
Bradycardia
EKG Changes
Prolonged PR interval
Decreased QT
Scooping on EKG
T Wave Inversion
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2 mins
Digoxin Toxicity Treatment
Activated Charcoal
Slowly Normalize K+
Digibind (Anti-Digoxin Fab)
Magnesium Sulfate
Lidocaine
Cardiac Pacing
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2 mins
Beta-1 Agonists
Dobutamine
Heart Failure
Cardiac Stress Test
Isoproterenol
Bradyarrhythmias
Torsades de Pointes
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1 min
Milrinone and Amrinone
Mechanism of Action
Phosphodiesterase 3 Inhibitor
Potentiates Beta Receptor Effects
Inotrope
Vasodilator
Indication
Acute Decompensated Heart Failure
Side Effects
Ventricular Arrhythmias
Hypotension
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2 mins
Atorvastatin (Lipitor)
Characteristics
-statin Suffix
Mechanism
HMG-CoA Reductase Inhibitors
Indications
High Cholesterol
Side Effects
Hepatotoxicity
Rash
Rhabdomyolysis
Myopathy
Considerations
Monitor Liver Enzymes
Administer at Bedtime
Avoid Grapefruit
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2 mins
Bile Acid Resins
Indications
Hyperlipidemia
Mechanism of Action
Bile Acid Reabsorption Prevented
Slight Increase HDL/Triglycerides
Decrease LDL
Drugs
Colestipol (Colestid)
Cholestyramine
Colesevelam
Side Effects
Cholesterol Gallstones
Decreased Absorption of Fat-soluble Vitamins
Patients Hate It
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2 mins
Bile Acid Resins
Indications
Hyperlipidemia
Mechanism of Action
Bile Acid Reabsorption Prevented
Decrease LDL
Drugs
Colestipol (Colestid)
Cholestyramine (Questran)
Colesevelam (Welchol)
Side Effects
GI Distress
Cholesterol Gallstones
Decreased Absorption of Fat-soluble Vitamins
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2 mins
Gemfibrozil (Fibrates)
Mechanism of Action
Decreases Triglycerides
Increase in HDL
Slight Decrease in LDL
Indications
Hypertriglyceridemia
Side Effect
Hepatotoxicity
Cholesterol Gallstones
Myopathy
Considerations
Do Not Combine with Statins
Warfarin Toxicity
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2 mins
Ezetimibe
Indications
Hyperlipidemia
Mechanism of Action
Cholesterol Absorption Blocker
Decreases LDL
Side Effects
Diarrhea
Increased LFT Values
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1 min
Fibrates
Indications
Hyperlipidemia
Mechanism of Action
Upregulate LPL
Decreases Triglycerides
Slight Increase in HDL
Slight Decrease in LDL
Side Effect
Hepatotoxicity
Cholesterol Gallstones
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1 min
Vitamin B3 - Niacin (Nicotinic Acid)
Mechanism
Decreases Triglycerides
Decreases LDL
Increases HDL
Indications
Dyslipidemia
Pellagra
Diarrhea
Dermatitis
Dementia
Side Effects
Flushing
GI Distress
Hepatotoxicity
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2 mins
Statins
Rhabdomyolysis
Hepatotoxicity
HMG-CoA reductase inhibitors
Decrease LDL
Decrease Triglycerides
Increase HDL
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2 mins
Aspirin (Acetylsalicylic Acid)
Mechanism
Inhibits Platelet Aggregation
NSAID
Indications
Thrombotic Event Prevention
General Pain
Inflammatory Conditions
Fever
Side Effects
Pancytopenia
GI Ulcers
Bleeding
Considerations
Withhold Before Surgery 7-10 Days
Reye's Syndrome
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2 mins
Warfarin (Coumadin)
Mechanism of Action
Inhibits Clotting Factors
Indications
Atrial Fibrillation
Venous Thrombosis
Pulmonary Embolism
Assessment
PT/INR Levels
Observe for Bleeding
Contraindications
Pregnancy
Nursing Considerations
Vitamin K and Fresh Frozen Plasma
Prolonged Therapeutic Onset
Maintain Same Diet
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2 mins
Heparin (Unfractionated)
Mechanism of Action
Suppresses Coagulation
Indications
Deep Vein Thrombosis (DVT)
Pulmonary Embolism
Side Effects
Hemorrhage
Heparin-Induced Thrombocytopenia (HIT)
Considerations
Monitor aPTT
Preferred (Safe) During Pregnancy
Antidote
Protamine Sulfate
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2 mins
Enoxaparin (Lovenox)
Mechanism of Action
Inhibits Clotting Factors
Factor Xa
Indications
Clot Formation Prevention
Side Effects
Heparin Induced Thrombocytopenia (HIT)
Bleeding
Considerations
Medication Education
Subcutaneous Injection
2 Inches from Umbilicus or Incisions
Antidote
Protamine Sulfate
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2 mins
Clopidogrel (Plavix)
Mechanism
ADP Receptor Antagonist
Prevent Platelet Aggregation
Indications
Acute Coronary Syndrome (ACS)
Prevention of Thrombotic Events
Side Effects
Bleeding
Thrombotic Thrombocytopenic Purpura (TTP)
Pancytopenia
Abdominal Pain
Considerations
Withhold Before Surgery
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2 mins
Ticlopidine (Ticlid)
Mechanism
ADP Receptor Antagonist
Irreversibly Inhibits Platelet Aggregation
Indications
Thrombotic Event Prevention
Side Effects
Neutropenia
Thrombotic Thrombocytopenic Purpura (TTP)
GI Distress
Rash
Considerations
Withhold Before Surgery
Monitor Blood Count
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2 mins
Alteplase
Mechanism
Tissue Plasminogen Activator
Indications
Thrombosis
Side Effects
Bleeding
Contraindications
Intracranial Hemorrhage
Internal Hemorrhaging
Considerations
Minimize Bleeding
Monitor for Shock
Antidote
Aminocaproic Acid
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2 mins
Abciximab and Tirofiban (GP IIb/IIIa Inhibitors)
Mechanism
IIb/IIIa Receptor Inhibitors
Inhibits Platelet Aggregation
Indications
Thrombotic Event Prevention
Acute Coronary Syndrome (ACS)
Percutaneous Coronary Intervention (PCI)
Side Effects
Bleeding
Considerations
Expensive
Combination Drug Therapy
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2 mins
Tamoxifen
Mechanism of Action
Selective Estrogen Receptor Modulator (SERM)
Antagonist on Breast Tissue
Indications
ER-positive Breast Cancer
Side Effects
Decreased Risk of Osteoporosis
Increased Risk of Endometrial Cancer
Increased Risk of Venous Thromboembolism (VTE)
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1 min
Busulfan
Indications
CML
Bone Marrow Ablation
Mechanism
Cross-Links DNA
Side Effects
Myelosuppression
Pulmonary Fibrosis
Hyperpigmentation
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55 secs
Cisplatin (Platinol)
Mechanism
Alkylating Agent
Cross-Links DNA
Indications
Testicular Cancer
Ovarian Cancer
Side Effects
Nausea and Vomiting
Myelosuppression
Nephrotoxicity
Ototoxicity
Peripheral Neuropathy
Considerations
Antiemetics Before Administration
Aggressive Hydration
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3 mins
Vincristine (Oncovin)
Mechanism
Vinca Alkaloid
Inhibits Microtubules
Indications
Leukemias
Lymphomas
Side Effects
Peripheral Neuropathy
Paralytic Ileus
Considerations
Vesicant
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2 mins
Bleomycin
Indications
Testicular Cancer
Hodgkin's Lymphoma
Mechanism of Action
Induces Free Radical Formation
Breaks in DNA Strands
Side Effects
Pulmonary Fibrosis
Skin Changes
Mucositis
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1 min
Hydroxyurea
Mechanism
Inhibits Ribonucleotide Reductase
Decreased DNA Synthesis
S-phase Specific
Indications
Melanoma
Chronic Myelogenous Leukemia (CML)
Sickle Cell Disease
Through Increased HbF (Fetal Hemoglobin)
Side Effects
Myelosuppression
GI Distress
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2 mins
Cyclophosphamide
Mechanism
Requires Bioactivation by Liver
Cross-links DNA
Guanine N7 Position
Indications
Autoimmune Disorders
Leukemia
Lymphoma
Solid Tumors
Side Effects
Myelosuppression
Hemorrhagic Cystitis
Prevent with Mesna
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3 mins
Rituximab
Indications
Chronic Lymphocytic Leukemia (CLL)
Non-Hodgkin Lymphoma
Rheumatoid Arthritis
Microscopic Polyangiitis (MPA)
Granulomatosis with Polyangiitis (Formerly Wegener's)
Mechanism
Monoclonal Antibody Against CD20
Found on B Cell Neoplasms
Side Effects
Infusion Reactions
Skin and Mouth Reactions
Reactivation of Hepatitis B Virus (HBV)
Progressive Multifocal Leukoencephalopathy (PML)
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3 mins
Silver Sulfadiazine (Silvadene) and Mafenide Acetate (Sulfamylon)
Mechanism
Topical Antimicrobial
Indications
Burns
Open Wound Care
Side Effects
Mafenide
Pain
Acidosis
Considerations
Administer Analgesic Prior to Wound Care
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1 min
Azoles (Ketoconazole)
"-azole" suffix
Indications
Local and Less Serious Systemic Mycosis
Mechanism
Inhibits Ergosterol Synthesis
Inhibits P450
Side Effects
Liver Dysfunction
Inhibition of Testosterone Synthesis
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1 min
Amphotericin B
Indications
Systemic Mycosis
Fungal Meningitis
Last Resort for Protozoan infections
Mechanism
Polyene
Binds Ergosterol
Forms Membrane Pores
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1 min
Amphotericin B Side Effects & Toxicity
Side Effects
Fever/Chills "Shake and Bake"
Nephrotoxicity
Milder with Liposomes
Hypotension
Anemia
IV Phlebitis
Arrhythmias
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1 min
Flucytosine
Indications
Cryptococcus
Candida
Used in Combination with Amphotericin B or Azoles
Mechanism
Inhibits DNA and RNA Synthesis
Converted to 5-FU by Cytosine Deaminase
Side Effects
Bone Marrow Suppression
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1 min
Griseofulvin
Mechanism
Disrupts Microtubules in Mitosis
Indications
Antifungal for Superficial Infections
Tinea and Ringworm
Side Effects
Teratogen
P450 Inducer
Confusion
Headache
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2 mins
Terbinafine
Indications
Dermatophytosis
Onychomycosis
Mechanism
Inhibits Squalene Epoxidase
Side Effects
Hepatotoxicity
GI Distress
Taste Disturbances
Headache
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2 mins
Echinocandins
"-Fungin" Suffix
Indications
Invasive Aspergillosis
Candida
Mechanism
Inhibits Cell Wall Synthesis
Inhibits Synthesis of Beta-glucan
Side Effects
GI Distress
Flushing
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1 min
Nystatin
Indications
Candidiasis
Vaginal
Oral
Cutaneous
Mechanism
Polyene
Binds Ergosterol
Forms Membrane Pores
Topical form of Amphotericin B
Side Effects
Rash
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1 min
NSAIDs
Indications
Anti-inflammatory
Analgesic
Fever
Closure of Patent Ductus Arteriosus
Mechanism of Action
Reversible Inhibition of COX-1 and COX-2
Block Prostaglandin Synthesis
Side Effects
Interstitial Nephritis
Gastric Ulcer
Renal Ischemia
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1 min
Reye's Syndrome
Cause
Aspirin (Salicylates) to Treat Viral Illness (In Children)
Assessment
Cerebral Edema
Lethargy (Decreased LOC)
Vomiting
Liver Failure
Interventions
Monitor for Increased ICP
Mannitol (Osmitrol)
Considerations
No Aspirin for Children
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2 mins
Ibuprofen (Advil, Motrin)
Mechanisms
NSAID
COX Inhibitor
Indications
General Pain
Fever
Inflammatory Conditions
Side Effects
GI Ulcers
Nephrotoxicity
Rash
Considerations
Avoid with Alcohol
Risk of Thrombotic Event
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2 mins
Prednisone (Glucocorticoids)
Mechanism
Glucocorticoid
Indications
Inflammatory Conditions
Organ Transplant Rejection
Side Effects
Cataracts and Glaucoma
Cushing's Syndrome
Osteoporosis
Immunosuppression
Hyperglycemia
Ulcers
Considerations
Adrenal Insufficiency
Taper Gradually
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2 mins
Acetaminophen
Indications
Fever
Pain
Mechanism of Action
Reversibly Inhibits COX
Acts Primarily in CNS
Side Effect
Hepatic Necrosis
N-acetylcysteine Antidote
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51 secs
Celecoxib
Indications
Rheumatoid Arthritis
Osteoarthritis
Pain
Mechanism of Action
NSAID
Selectively Inhibits COX-2
Side Effects
Sulfa Allergy
Increased Risk of Thrombosis
GI Bleed
Contraindication
Pregnancy > 30 Weeks
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1 min
Opioids Overview
Indications
Pain
Weaning
Cough
Diarrhea
Mechanism of Action
Agonists at Mu (μ), Kappa (Κ), and Delta (δ) Receptors
Decrease Synaptic Transmission
Side Effects
Respiratory Depression
Addiction
Miosis
Constipation
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2 mins
Opioid Use Disorder and Withdrawal Assessment (Formerly Opioid Abuse and Withdrawal Assessment)
Abuse Assessment
Euphoria
Miosis
CNS Depression
Abuse Withdrawal
Yawning
Gooseflesh
Sweating
Rhinorrhea
Kicking Movements
Consideration
Naloxone
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1 min
Alendronate (Fosamax)
Mechanism
Inhibits Osteoclasts
Indications
Osteoporosis
Paget's Disease
Side Effects
Esophageal Ulcers
Musculoskeletal Pain
Vision Changes
Atrial Fibrillation
Osteonecrosis of the Jaw
Considerations
Take on Empty Stomach
Remain Upright
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2 mins
Hydroxychloroquine
Mechanism of Action
Immunosuppressant
Indications
Malaria
Rheumatoid Arthritis
Systemic Lupus Erythematosus (SLE)
Porphyria Cutanea Tarda
Side Effects
Cardiotoxicity
Retinopathy
Considerations
Ophthalmological Exams
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3 mins
Raloxifene
Mechanism of Action
Selective Estrogen Receptor Modulator (SERM)
Agonist in Bone
Antagonist in Breast and Uterus
Indications
Osteoporosis
Breast Cancer Prophylaxis
Uterine Fibroids
Side Effects
Hot Flashes
Thromboembolism
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2 mins
Mannitol (Osmitrol)
Mechanism
Osmotic Diuresis
Indications
Reducing Intracranial Pressure
Reducing Intraocular Pressure
Renal Failure Prophylaxis
Side Effects
Edema
Fluid and Electrolyte Imbalance
Considerations
Avoid Use in Cardiac Patients
IV Administration
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2 mins
Loop Diuretics
Mechanism of Action
Thick Ascending Limb of Loop of Henle
Inhibits Na+-K+-2Cl-
Sulfa Drug
Drug Names
Furosemide
Lasix
Side Effects
Ototoxicity from Rapid Injection
Gout
Dehydration
Hypocalcemia
Hypokalemia
Orthostatic Hypotension
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2 mins
Loop Diuretic Education
Furosemide (Lasix)
Indications
Heart Failure
Pulmonary Edema
Acute Renal Failure (ARF)
Edema
Education
Notify the provider of weakness, dizziness, or muscle cramping
Increase Potassium Intake
Check BP Daily
Daily Weights and Monitor IandOs
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1 min
Ethacrynic Acid
Mechanism of Action
Non-sulfa Drug
Phenoxyacetic Acid Derivative
Loop Diuretic
Inhibits Na+-K+-2Cl- Cotransporter
Thick Ascending Loop of Henle
Clinical Use
Diuresis
Side Effects
Hypokalemia
Ototoxicity
Gout
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2 mins
Hydrochlorothiazide HCTZ
Mechanism of Action
Inhibits Reabsorption NaCl and H2O
Indications
Edema
Mild to Moderate Hypertension
Side Effects
Hypokalemia
Hyponatremia
Dehydration
Hyperglycemia
Gout
Contraindications
Sulfa Allergy
Pregnancy and Breastfeeding
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1 min
Spironolactone (Aldactone)
Mechanisms
Inhibition of Aldosterone
Potassium Retention
Indications
Hypertension
Edema
Heart Failure
Side Effects
Hyperkalemia
Endocrine Effects
Consideration
Avoid Potassium Supplements
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2 mins
Erythropoietin
Mechanism
Stimulates RBC Production
Indications
Chronic Renal Failure
Anemia
Side Effects
Increased Risk of Thrombosis
Pelvic and Limb Pain
Hypertension
Considerations
Do Not Shake
Monitor Hemoglobin (Hgb) Weekly
May Accelerate Tumor Progression
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2 mins
Insulin
Rapid Acting
Insulin Lispro (Humalog)
Insulin Aspart (Novolog)
Insulin Glulisine (Apidra)
Short Acting
Regular Insulin (Humulin R)
Intermediate Acting
Isophane NPH (Humulin N)
Long Acting
Detemir (Levemir)
Glargine (Lantus)
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2 mins
Metformin (Glucophage)
Mechanism
Decrease Glucose Production
Increase Insulin Sensitivity
Indications
Type 2 Diabetes
Polycystic Ovary Syndrome (PCOS)
Side Effects
GI Distress
Decreased Appetite
Lactic Acidosis
Considerations
IV Contrast
Limit Alcohol Consumption
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2 mins
Mixing NPH and Regular Insulin for Injection
Verify Order
Roll NPH Insulin
Alcohol to Multiuse Vials
Inject Air into NPH Insulin (Cloudy)
Inject Air into Regular Insulin (Clear)
Withdraw Regular Insulin Units
Withdraw NPH Units
Verify with 2nd Nurse
Discard if Error
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3 mins
Chlorpropamide and Tolbutamide (Orinase) (1st Generation Sulfonylureas)
Mechanisms
1st Generation Sulfonylureas
Stimulate Release of Insulin
Indications
Type 2 Diabetes
Side Effects
Hypoglycemia
Possible Cardiovascular Toxicity
Weight Gain
Considerations
Exacerbated Hypoglycemia with Beta-blockers
Avoid During Pregnancy and Breast Feeding
Avoid Alcohol
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2 mins
Glyburide and Glipizide (2nd Generation Sulfonylureas)
Mechanisms
2nd Generation Sulfonylureas
Blocks Potassium Channels in Beta Cells
Stimulate Release of Insulin
Indications
Type 2 Diabetes
Side Effects
Hypoglycemia
Considerations
More Potent
Beta Blockers Reduce Effects
Avoid Alcohol
Avoid Breastfeeding
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2 mins
Pioglitazone (Thiazolidinediones)
-glitazones Suffix
Mechanism
Binds PPAR-Gamma
Decreases Insulin Resistance
Indications
Type 2 Diabetes
Side Effects
Weight Gain
Heart Failure
Myalgia
Hypoglycemia
Upper Respiratory Infection
Considerations
Increased Risk of Bladder Cancer
Increased Fracture Risk in Women
Monitor Liver Enzymes
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2 mins
Acarbose (Precose) and Miglitol (Glyset) (Alpha Glucosidase Inhibitors)
Mechanisms
Alpha Glucosidase Inhibitors
Delays Absorption of Carbohydrates
Indications
Type 2 Diabetes
Side Effects
Flatulence
Diarrhea
Anemia
Cramps
Considerations
Monitor LFTs
Oral Glucose for Hypoglycemia
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2 mins
Repaglinide and Nateglinide (Meglitinides)
Mechanisms
Meglitinides
Increased Insulin Release
Indications
Type 2 Diabetes
Side Effect
Hypoglycemia
Considerations
Eat Within 30 Minutes
Gemfibrozil Increases Risk of Hypoglycemia
Short Half-Life
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2 mins
Sitagliptin (Januvia) and Saxagliptin (Onglyza) (DPP-4 Inhibitors)
-gliptin Suffix
Mechanisms
DPP-4 Inhibitor
Increases Insulin Release
Indications
Type 2 Diabetes
Side Effects
Pancreatitis
Upper Respiratory Infection and Inflammation
Stevens-Johnson Syndrome
Considerations
Used as Add-on Agents
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2 mins
Pramlintide (Symlin)
Mechanism
Synthetic Amylin Analog
Indications
Diabetes Type 1 and 2
Supplement Mealtime Insulin
Side Effects
Nausea
Skin Reactions at Injection Site
Considerations
Hypoglycemia When Combined with Insulin
Delayed Absorption of Oral Drugs
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2 mins
Exenatide (Byetta)
Mechanism
Incretin Mimetic
GLP-1 Synthetic Analog
Indications
Type 2 Diabetes
Side Effects
Hypoglycemia
Nausea and Vomiting
Diarrhea
Thyroid Cancer
Pancreatitis
Renal Failure
Considerations
(Give Exenatide) One Hour After Other Medications
Adjunct Therapy
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3 mins
Glucagon (GlucaGen)
Mechanism
Increases Glucose
Indications
Hypoglycemic Emergency
Side Effects
Nausea and Vomiting
Considerations
Reconstitute Powder
Consume Oral Carbohydrates
50% Dextrose IV (If No Effect)
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2 mins
Levothyroxine (Synthroid)
Mechanism
Synthetic T4
Indications
Hypothyroidism
Side Effects
Thyrotoxicosis
Tremors
Heat Intolerance
Insomnia
Tachycardia
Considerations
Do Not Use for Obesity
TSH Monitoring
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2 mins
Propylthiouracil (PTU) and Methimazole (MMI)
Indications
Hyperthyroidism
Mechanism
Inhibits Thyroid Peroxidase
PTU Blocks Peripheral Conversion of T4 to T3
Side Effects
Agranulocytosis
Skin Rash
Hepatotoxicity (PTU)
Teratogen (MMI)
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1 min
Tacrolimus (Prograf) Overview
Mechanisms
Immunosuppressant
Inhibits Calcineurin, Decreasing IL-2
Indications
Transplant Rejection
Atopic Dermatitis
Considerations
Increased Lymphoma Risk
Avoid Grapefruit Juice
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1 min
Tacrolimus (Prograf) Side Effects
Nephrotoxicity
Neurotoxicity
GI Distress
Infection
Hypertension
Hyperkalemia
Hyperglycemia
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1 min
Cyclosporine (Sandimmune) Overview
Mechanism
Immunosuppressant
Inhibits Calcineurin, Decreasing IL-2
Indications
Prevent Transplant Rejection
Psoriasis
Rheumatoid Arthritis
Considerations
Monitor Plasma Levels
Avoid Grapefruit Juice
Increased Risk of Lymphoma
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2 mins
Cyclosporine (Sandimmune) Side Effects
Side Effects
Nephrotoxicity
Hepatotoxicity
Infection
Hypertension
Hirsutism
Tremor
Hyperkalemia
Hypomagnesemia
Gingival Hyperplasia
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1 min
Methotrexate
Indications
Rheumatoid Arthritis
Cancer
Medical Abortion
Mechanism
Folic Acid Analog
Inhibits Dihydrofolate Reductase
Side Effects
Pulmonary Fibrosis
Myelosuppression is Treated with Leucovorin Rescue (Folinic Acid)
Macrocytic Anemia
Hepatitis
Teratogenic
Mucositis
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2 mins
Omeprazole (Prilosec)
"-prazole" Suffix
Indications
Zollinger-Ellison Syndrome
Gastritis
Peptic Ulcer
Gastroesophageal Reflux Disease (GERD)
Mechanism
Proton Pump Inhibitor (PPI)
Inhibit H+/K+/ATPase
Side Effects
Hip Fracture
Pneumonia
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2 mins
Cimetidine and Famotidine (H2 Receptor Blockers)
-tidine Suffix
Mechanism
H2 Receptor Blocker
Indications
Suppress Gastric Acid Secretion
Side Effects (All)
Pneumonia
Side Effects - Cimetidine
Anti-androgen Effects
CNS Changes
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2 mins
Pancreatin, Pancrelipase (Pancreatic Enzymes)
Mechanism
Pancreatic Enzymes
Indications
Cystic Fibrosis
Pancreatic Insufficiency
Side Effects
GI Distress
Considerations
Inactivated by Gastric Acid
24 Hour Fat Excretion
Take with Every Meal and Snack
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2 mins
Sucralfate (Carafate)
Mechanism
Creates Protective Barrier
Indications
GI Ulcers
Side Effects
Constipation
Considerations
Require Acidic Environment
Give on Empty Stomach
Oral Suspension Available
May Decrease Absorption of Other Meds
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2 mins
Activated Charcoal (Actidose)
Mechanism
Binds to Toxins
Indications
Ingested Poison
Side Effects
Black Stool
GI Distress
Considerations
Give As Soon As Possible
Via Mouth or NG Tube
Gastric Lavage
Do Not Administer with Antidotes
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2 mins
Promethazine (Phenergan)
Mechanism
Histamine H1 Receptor Antagonist
Weak Dopamine Antagonist
Indications
Nausea and Vomiting
Motion Sickness
Side Effects
Respiratory Depression
Sedation
Anticholinergic Effects
Extrapyramidal Symptoms
Considerations
Use Large Bore IV
Monitor for Tissue Necrosis
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2 mins
Ondansetron
Indications
Postoperative Vomiting
Chemotherapy-induced Nausea and Vomiting
Mechanism
5-HT3 Serotonergic Antagonist
Centrally-acting Antiemetic
Side Effects
Headache
Constipation
QT Prolongation
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1 min
Osmotic Laxatives
Mechanism of Action
Increases Osmotic Load
Indications
Hepatic Encephalopathy
Constipation
Drugs
Magnesium Hydroxide
Magnesium Citrate
Polyethylene Glycol
Sorbitol
Lactulose
Side Effects
Diarrhea
Dehydration
Considerations
Misused in Bulimia Nervosa
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2 mins
Metoclopramide
Indications
Antiemetic
Promotility Agent
Mechanism
Increased Resting Tone
Antagonist at D2 Receptor
Side Effects
Parkinsonian Symptoms
Galactorrhea
Contraindication
Small Bowel Obstruction
Parkinson's Disease
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2 mins
Proton Pump Inhibitors (PPIs)
"-prazole" Suffix
Indications
Zollinger-Ellison Syndrome
Gastritis
Peptic Ulcer
Gastroesophageal Reflux Disease (GERD)
Mechanism
Inhibit H+/K+/ATPase
Side Effects
Hip fracture
Pneumonia
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2 mins
Orlistat
Mechanism
Inhibits Gastric and Pancreatic Lipase
Decrease Absorption of Fat
Clinical Use
Weight Loss
Side Effects
Increased Bowel Movements
Steatorrhea
Abdominal Pain
Flatulence
Calcium Oxalate Kidney Stones
Decreased Absorption of Fat-Soluble Vitamins
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2 mins
Hepatitis C Pharmacotherapy
NS3/4A Inhibitors
Glecaprevir
Grazoprevir
Simeprevir
NS5A Inhibitors
Ledipasvir
Elbasvir
Velpatasvir
NS5B Inhibitors
Sofosbuvir
RNA Polymerase Inhibitor
Ribavirin
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2 mins
Vitamin A (Retinol)
Mechanism
Maintains Mucous Membranes
Eyes and Skin
Indications
Dietary Deficiency
Skin Disorders
Side Effects
Hepatosplenomegaly
Jaundice
Increased ICP
Vomiting
Considerations
Teratogen
Animal Food Products
Dark Green and Orange Fruits/Vegetables
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2 mins
Vitamin B1 (Thiamine)
Mechanism
Carbohydrate Metabolism
Indications
Dietary Deficiency
Beriberi
Wernicke-Korsakoff
Considerations
Alcoholics Highest Risk
Give Before Glucose
Give IM or IV
Enriched Whole Grains
Pork
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2 mins
Beriberi (Thiamine Deficiency)
Mechanism
Thiamine Deficiency
Assessment
Dry Beriberi
Polyneuritis
Muscle Wasting
Wet Beriberi
Dilated Cardiomyopathy
Edema
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2 mins
Vitamin B6 (Pyridoxine)
Mechanism
Amino Acid and Protein Metabolism
Heme Synthesis
Neurotransmitters
Indications
Adjunct to Isoniazid
Dietary Deficiency
Premenstrual Syndrome (PMS)
Side Effects
Ataxia
Peripheral Neuropathy
Contraindications
Levodopa
Considerations
Cereals and Meats
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3 mins
Cobalamin (Vitamin B12)
Mechanism
Vitamin B12
Indications
Vitamin Deficiency
Pernicious Anemia
Side Effects
Hypokalemia
Arthralgia
Dizziness
Considerations
IM Injection for Pernicious Anemia
Never Give IV
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2 mins
Vitamin C (Ascorbic Acid)
Mechanism
Antioxidant
Collagen Formation
Steroid Synthesis
Indications
Dietary Deficiency
Scurvy
Side Effects
GI Distress
Considerations
Citrus Fruits
May Improve Healing
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2 mins
Ergocalciferol (Vitamin D2)
Mechanism
Vitamin D2
Indications
Hypoparathyroidism
Rickets
Hypophosphatemia
Side Effects
Fatigue
Constipation
Hypercalcemia
Kidney Stones
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2 mins
Vitamin E (Alpha-tocopherol)
Mechanism
Antioxidant
Indications
Fat Malabsorption Syndrome
Alpha-TTP Deficiency
Side Effects
Bleeding
Considerations
Increased Risk Hemorrhagic Stroke
Limit Doses < 200 IU per Day
Nuts and Whole Grains
Vegetable Oils
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2 mins
Vitamin K1 (Phytonadione)
Mechanism
Synthesizes Clotting Factors II, VII, IX, X
Indications
Hypoprothrombinemia
Newborn Prophylaxis
Bleeding from Warfarin Overdose
Side Effects
Shock
Kernicterus
Cardiac Arrest
Considerations
Bile Salts required for Intestinal Absorption
Increased Risks with IV Administration
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2 mins
Iron (Ferrous Sulfate)
Mechanism
Ferrous Salts
Indications
Anemia
Side Effects
GI Distress
Nausea and Vomiting
Dark Stools
Considerations
Take Between Meals
Liquid can Stain Teeth
Keep out of Reach from Children
Caution with GI Disorders
Avoid Antacids
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3 mins
Total Parenteral Nutrition (TPN)
Mechanism
Nutrition Given Outside GI
Side Effects
Hyperglycemia
Hyperlipidemia
Refeeding Syndrome
Nausea and Vomiting
Considerations
Slow IV Infusion
Use Large Central Vein
No Added Meds to TPN Line
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2 mins
Cholecalciferol (Vitamin D3)
Mechanism
Vitamin D3
Indications
Dietary Supplement
Vitamin D Deficiency
Side Effects
Fatigue
Constipation
Hypercalcemia
Kidney Stones
Considerations
More Effective Than Ergocalciferol
Hypervitaminosis D
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2 mins
Vitamin D Deficiency
Signs & Symptoms
Rickets in children
Bending bones
Rachitic rosary
Breast milk has decreased vitamin D
Osteomalacia in adults
Tetany from Hypocalcemia
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2 mins
RhoGam [Rho(D) Immune Globulin]
Indications
Antepartum Prevention at 28 weeks
Suppress Antibody Production
Mechanism of Action
Lysis of Fetal RBC in Maternal Bloodstream
Side Effects
Myalgia and Lethargy
Considerations
Negative Coombs Test
Standard Dose 300 mcg
Microdose 50 mcg
Blood Product
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2 mins
Isoniazid
Indications
Tuberculosis (TB)
Mechanism of Action
Requires Catalase Peroxidase
Decreases Mycolic Acid Synthesis
Fast vs Slow Acetylators
Side Effects
B6 Deficiency
Neurotoxicity
Hepatotoxicity
Drug-induced Lupus
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1 min
Leuprolide
Mechanism
GnRH Agonist (Pulsatile Use)
GnRH Antagonist (Continuous Use)
Upregulates FSH And LH
Downregulates FSH And LH
Indications Pulsatile
Infertility
Indications Continuous
Prostate Cancer
Precocious Puberty
Uterine Fibroids
Endometriosis
Side Effects
Anti-androgenic Effects
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2 mins
Macrolides
Bacteriostatic
Erythromycin
Azithromycin
Clarithromycin
Bind to 23S rRNA of 50S subunit
Inhibit protein synthesis by blocking translocation
Gram-Positive Cocci
Atypical pneumonia
Chlamydia
Resistance by methylation of 23S rRNA binding
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1 min
Methylergonovine (Methergine) and Ergotamine (Ergot Alkaloids)
Mechanism
Smooth Muscle Contraction
Vasoconstriction
Indications
Migraine
Postpartum Hemorrhage
Side Effects
Nausea and Vomiting
Severe Hypertension
Tachycardia
Considerations
2nd Line Agent
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2 mins
Ethambutol
Mechanism of Action
Bacteriostatic
Blocks Arabinosyltransferase
Arabinosyltransferase Polymerizes Carbohydrates
Carbohydrate Polymers Make Mycobacterium TB Cell Wall
Side Effects
Red/Green Color Blindness
Reversible with Drug Discontinuation
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40 secs
Oxytocin (Pitocin)
Mechanism of Action
Increase Uterine Contractions
Indications
Labor Induction
Control Postpartum Hemorrhage
Side Effects
Uterine Rupture
Water Intoxication
Contraindications
Fetal Lung Immaturity
Cervix Not Ripened
Active Genital Herpes Infection
Considerations
Use Lowest Dose
IV Pump
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3 mins
Rifampin
Tuberculosis (TB)
Blocks RNA Polymerization
Haemophilus influenzae Type B
Leprosy
Meningitis
P450 inducer
Red-orange urine
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55 secs
Carboprost (Hemabate)
Mechanism
Prostaglandin F2-alpha Analog
Smooth Muscle Contraction
Indications
Postpartum Hemorrhage
Abortion
Side Effects
GI Distress
Hypertension
Fever
Bronchoconstriction
Considerations
Identify Cause of Fever
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2 mins
Foscarnet
Indications
CMV Retinitis
Acyclovir-resistant HSV
Mechanism
Does Not Require Activation (by Viral Kinase)
Inhibits Viral DNA Polymerase
Pyrophosphate Analog
Resistance through Mutated DNA Polymerase
Side Effects
Nephrotoxicity
Electrolyte Abnormalities
Hypokalemia
Hypocalcemia
Hypomagnesemia
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2 mins
Dinoprostone and Misoprostol
Mechanism
Prostaglandins
Indications
Promote Cervical Ripening
Prevent GI Ulcers
Medical Abortion
Side Effects
Fetal Distress
Hyperstimulation of Uterus
Considerations
Vaginal Insertion
Give Before Induction of Labor
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2 mins
Ganciclovir
Indications
Cytomegalovirus (CMV)
Immunocompromised
Mechanism
Guanosine Analog
Disrupts DNA Synthesis
Inhibits Viral DNA Polymerase
Side Effects
Hematologic Effects
Nephrotoxicity
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1 min
Terbutaline (Brethine)
Mechanism of Action
Beta-2 Agonists
Indications
Asthma
Tocolytic
Side Effects
Hypotension
Tremor
Tachycardia
Pulmonary Edema
Hyperglycemia
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2 mins
Mifepristone, Ulipristal (Antiprogestins)
Mechanism of Action
Progesterone Receptor Antagonist
Indications
Mifepristone
Pregnancy Termination With Misoprostol
Ulipristal
Emergency Contraception
Side effects
Abdominal Pain
Vomiting
Diarrhea
other mechanisms of action
At High Doses: Cortisol Antagonist
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2 mins
Clomiphene
Indications
Infertility
Polycystic Ovarian Syndrome (PCOS)
Mechanism of Action
Selective Estrogen Receptor Modulator (SERM)
Hypothalamus
Estrogen Antagonist
Increased GnRH, LH and FSH Secretion
Induction of Ovulation
Side Effects
Multiple Gestations
Visual Disturbances
Hot Flashes
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2 mins
Posterior Column (Dorsal Column)
Ascending Pathway (Sensory)
Sensations
Proprioception
Fine Touch
Pressure
Vibration Sensation
Anatomy
Dorsal Root
Fasciculus Cuneatus
Arms
Fasciculus Gracilis
Lower Limbs
Lesions
Vitamin B12 Deficiency
Tabes Dorsalis
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2 mins
Beta-2 Agonists
Short-term Treatment
Terbutaline
Asthma
Tocolysis
Albuterol
Asthma
Long-term Treatment
Salmeterol
Asthma
Chronic Obstructive Pulmonary Disease (COPD)
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3 mins
NRTIs (Nucleoside Reverse Transcriptase Inhibitors)
Indications
HIV
Pregnancy and Prophylaxis given ZDV
Mechanism
Inhibit Nucleotide Binding to Reverse Transcriptase
Chain Termination
Require Phosphorylation
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1 min
Albuterol (Proventil)
Mechanism
Short-Acting Beta-2 Agonist
Indications
Bronchospasm
Asthma
Side Effects
Angina
Tachycardia
Tremor
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1 min
Cromolyn (Mast Cell Stabilizers)
Mechanism
Mast Cell Stabilizer
Indications
Asthma Prophylaxis
Bronchial Inflammation
Allergic Rhinitis
Side Effects
Cough
Bronchospasm
Consideration
Fixed Schedule Administration
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2 mins
Theophylline (Theo-24)
Mechanism
Bronchial Smooth Muscle Relaxation
Indications
Asthma
Side Effects
Insomnia
Restlessness
Arrhythmias
Seizures
Considerations
Narrow Therapeutic Range
Monitor Plasma Levels
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1 min
Cidofovir
Indications
CMV Retinitis
Acyclovir-Resistant HSV
Mechanism
Inhibits Viral DNA Polymerase
Side Effects
Nephrotoxicity
Administer with Probenecid and IV Saline
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1 min
Montelukast (Singulair)
Mechanism
Leukotriene Receptor Blocker
Indications
Allergic Rhinitis
Asthma Prophylaxis
Exercise Induced Bronchospasm
Side Effects
Fatigue
Headache
Mood Changes
Suicidal Thoughts
Considerations
Increased Risk of Churg Strauss
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2 mins
Zanamivir (Relenza) and Oseltamivir (Tamiflu)
Indications
Influenza A and B
Treatment and Prophylaxis
Mechanism
Inhibits Release of New Virus
Inhibits Influenza Neuraminidase
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1 min
NRTI Toxicity
Bone Marrow Suppression
Reverse with G-CSF and Erythropoietin
Rash
Neuropathy
Anemia
Pancreatitis
Lactic Acidosis
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1 min
Second Generation Antihistamines
Indications
Allergies
Mechanism of Action
Lipophobic
Histamine H1 Receptor Antagonist
Drugs
Azelastine + Fluticasone (Dymista)
Intranasal Spray
Cetirizine (Zyrtec)
Loratadine (Claritin)
Fexofenadine (Allegra)
Considerations
Fewer Anticholinergic Effects
Fewer CNS Effects
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2 mins
NNRTIs (Non-nucleoside Reverse Transcriptase Inhibitors)
Indications
HIV
Mechanism
Do Not Require Intracellular Metabolism
Inhibits Reverse Transcriptase
Side Effects
Rash
Hepatotoxicity
Vivid Dreams and CNS Symptoms
Contraindication
Pregnancy
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2 mins
First Generation Antihistamines
Mechanism of Action
Histamine H1 Receptor Antagonist
Indications
Allergies
Nausea and Vomiting
Motion Sickness
Anaphylaxis
Drug Names
Diphenhydramine (Benadryl)
Promethazine (Phenergan)
Chlorpheniramine
Side Effects
Sedation
Anticholinergic Effects
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2 mins
Stages of Asthma Treatments
Mild Intermittent
Short-acting Inhaled Beta-Agonist
Mild Persistent
Low-Dose Inhaled Corticosteroid
Montelukast (Leukotriene Receptor Antagonist)
Moderate Persistent
Low to Medium-dose Inhaled Corticosteroid
Zileuton
Severe Persistent
High-Dose Inhaled Corticosteroid
Systemic Corticosteroids
Omalizumab (Allergies)
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2 mins
Isoniazid (INH)
Mechanism
Interferes with DNA Metabolism
Indications
Tuberculosis (TB)
Side Effects
Optic Neuritis
Nausea and Vomiting
Hepatotoxicity
Peripheral Neuropathy
Considerations
Vitamin B6 Prophylaxis
Monitor AST/ALT
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2 mins
Ethambutol (Myambutol)
Mechanisms
Inhibits RNA Synthesis
Bacteriostatic
Indications
Tuberculosis (TB)
Side Effects
Optic Neuritis
Red/Green Color Blindness
Gouty Arthritis
Consideration
Monitor Vision Acuity
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2 mins
Antibiotics Overview
Cell Wall Inhibitors
Cell Wall Inhibitors
Penicillins
Cephalosporins
Monobactams
Carbapenems (Imipenem & Meropenem)
Beta-Lactamase Inhibitors
Protein Synthesis Inhibitors
Protein Synthesis Inhibitors
Aminoglycosides
Macrolides
Clindamycin
Tetracyclines
Linezolid
Chloramphenicol
Other
Fluoroquinolones
Sulfonamides
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4 mins
Penicillin
Mechanism of Action
Weakens Cell Wall
Indications
Gram-Positive Infections
Prophylaxis
Side Effects
Pain at IM Injection Site
Allergic Reaction
Considerations
Skin Tests
Allergy ID
Medication Education
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2 mins
Alpha 1 Receptor
Characteristics
Gq Subunit
Increase Vascular Smooth Muscle Contraction
Increase Pupillary Dilator Muscle Contraction
Increase Intestinal and Bladder Sphincter Muscle Contraction
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1 min
Alpha 2 Receptor
Characteristics
Gi Subunit
Decrease Sympathetic Outflow
Decrease Insulin Release
Decrease Lipolysis
Increase Platelet Aggregation
Decrease Aqueous Humor Production
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2 mins
Beta-1 Receptor
Characteristics
Gs Protein Class
Increased Heart Rate
Increased Contractility
Increase Renin Release
Increased Lipolysis
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44 secs
Beta-2 Receptor
Characteristics
Gs protein class
Increased Heart Rate
Increased Contractility
Increased Lipolysis
Increased Insulin
Increased Aqueous Humor Production
Ciliary Muscle Relaxation
Vasodilation
Bronchodilation
Decrease Uterine Tone
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2 mins
P450 Inhibitors
Quinidine
Ciprofloxacin
Isoniazid
Grapefruit Juice
Acute Alcohol Use
Erythromycin (Macrolide)
Indinavir
Cimetidine
Sulfonamides
Ketoconazole
Amiodarone
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