Antibody circulating within blood vessels attaches to antigen forming circulating immune complexes that then deposit in various locations.
These immune complexes activate complement via antibody binding to Fc receptors of leukocytes. This results in inflammation.
Inflammation occurs due to neutrophil release of lysosomal enzymes and reactive oxygen intermediates.
This is an example of a local immune complex disease that usually occurs in the skin.
This is an example of systemic immune complex disease that occurs due to a patient receiving non-human animal serum in significant amounts.
This is a chronic type of serum sickness that occurs due to antibody formation against nuclear antigens.
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