Tricuspid regurgitation is characterized by a holosystolic murmur that begins from S1 and continues to S2. This murmur is holosystolic because the faulty tricuspid valve allows blood to flow backwards to the right atrium during all of systole.
This murmur is classically described as having a blowing quality.
This murmur can be distinguished from mitral regurgitation on physical exam because it radiates to the right sternal border as opposed to the apex of the heart. Though a right-sided heart defect, tricuspid regurgitation is best auscultated on the lower left sternal border.
This murmur can be distinguished from mitral regurgitation, which is also holosystolic, because it increases with inspiration due to an increase in return from the venous circulation to the right heart, resulting in a larger volume of blood that flows back to the right atrium.
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