Naturally occurring metalloid element that can cause ingestion toxicity due to arsenic-containing insecticides or drinking water. It inhibits lipoic acid, a cofactor for pyruvate dehydrogenase leading to lactic acidosis and neurological deficiencies. Acute toxicity can lead to nausea, vomiting, abdominal pain, rice water stools and garlic breath. Toxicity is associated with squamous cell carcinoma of the skin, lung cancer, and liver angiosarcoma.
Naturally occurring metalloid element that can cause toxicity due to its use in the treatment of rheumatoid arthritis. Toxicity can cause dermatitis, stomatitis, hematuria and proteinuria.
Naturally occurring metalloid element that can result in toxicity due to ingestion or absorption of excess copper from acidic foods or beverages kept in contact with copper containers. Toxicity can cause gastroenteritis, nausea, vomiting, diarrhea, hemolytic anemia, and basal ganglia degeneration. Toxicity can also be due to inherited Wilson's Disease.
A chelating agent that can remove various metalloid elements, including copper, arsenic and gold from tissues.
Dimercaprol, or BAL (British anti-Lewisite), is an antidote for treating toxic metal poisoning. It is used for arsenic, gold, mercury and lead. In the past, it was used for treatment of copper poisoning from Wilson's disease, but is not commonly used for this purpose currently. This drug chelates medications, allowing them to be excreted safely. Dimercaprol has a very narrow therapeutic range, and can lead to side effects of nephrotoxicity and hypertension.
Succimer is an oral medication taken to treat poisoning for arsenic, but also lead and mercury. This drug is a chelator, which binds to the toxic metals in the bloodstream and eliminates them in the urine.
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