Class I anti-arrhythmic agent that acts on fast inward sodium currents.
A fluoroquinolone antibiotic that is commonly used for gram negative rod infections of the urinary and GI tracts. It works by interfering with topoisomerase II.
Decreases the synthesis of mycolic acids, which is a key component of Mycobacterium tuberculosis. It is the only agent used for monotherapy prophylaxis against TB.
Grapefruit juice is a well known substance that causes decreased activity of the P450 system leading to toxicities caused by slow metabolism of other P450 drugs.
Acute alcohol use causes inhibition of the P450 system because the P450 enzymes are saturated by the toxic metabolites of acute ingestion.
A macrolide antibiotic that is commonly used for Bordetella pertussis, Legionella pneumophilia and Mycoplasma pneumoniae. It inhibits protein synthesis by binding to the 23s RNA of the 50s ribosomal subunit, thereby blocking translocation.
An HIV protease inhibitor that is used as a component of antiretroviral therapy in treatment of HIV and AIDS.
A histamine H2 receptor antagonist that is commonly used in the treatment of heartburn by decreasing stomach acid production.
A class of drugs containing the sulfonamide group. Also called sulfa drugs, these medications often interact with the P450 system. Common sulfonamides are antibiotics, diuretics and sulfonylureas.
Ketoconazole is commonly used for systemic mycoses. It acts by inhibiting fungal ergol sterol synthesis.
Amiodarone is an antiarrhythmic medication which is a potent inhibitor of a number of cytochrome P450 enzymes.
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