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Trastuzumab

Trash-tumor-man
Picmonic
Trastuzumab, or Herceptin, is an anticancer medication that is a monoclonal antibody against HER-2. HER-2 is a tyrosine kinase receptor that is overexpressed by breast cancer cells. This medication can also be used against HER-2 positive gastric cancers. It can lead to congestive heart failure and cardiotoxicity in patients.
6 KEY FACTS
INDICATIONS
HER-2+ Breast Cancer
HER (2) Tutu (+) Positive Breast with Tumor-guy

This cancer medication is used to treat HER-2+ breast cancers. HER-2 stands for human epidermal growth factor receptor-2, and is overexpressed in roughly 1 out of 5 breast cancers. 

Stomach cancer
Stomach Tumor-guy

Trastuzumab can also be used to treat HER-2+ gastric cancers. A gastric cancer that is HER-2+ positive overexpresses the HER-2+ tyrosine kinase receptor, and is more responsive to trastuzumab.

MECHANISM
Monoclonal antibody against HER-2
Monocle-wearing Ant-tie-bodies against Tumor-guy

Trastuzumab is a monoclonal antibody against HER-2. This drug binds to cancer cells, and this binding leads to antibody mediated (complement mediated) killing of the HER-2 positive cancer cells.

Inhibition of Cellular Signaling
Breaking Cellular-phone Signal with Inhibiting-chains

One of the mechanisms of Trastuzumab's effects on cancer is that it inhibits HER-2-initiated cellular signaling. It is proposed that tumor cells arise from unchecked signaling and proliferation, and this drug works to decrease signalling amongst tumor cells.

Cytotoxicity
Side-toe with Toxic-green-glow

Trastuzumab binding to cancer cells leads to antibody mediated (complement mediated) killing of the HER-2 positive cells.

SIDE EFFECTS
Cardiotoxicity
Heart with Toxic-green-glow

One of the more serious complications of this medication is cardiotoxicity. Patients may develop congestive heart failure and other possible cardiomyopathies.

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