Master Hydroxyurea with Picmonic for Medicine

With Picmonic, facts become pictures. We've taken what the science shows - image mnemonics work - but we've boosted the effectiveness by building and associating memorable characters, interesting audio stories, and built-in quizzing.

Hydroxyurea

Hydra-u-rainbow
Picmonic
Hydroxyrurea is an antimetabolite medication, which acts by suppressing ribonucleotide reductase, an enzyme that reduces ribonucleotides into deoxyribonucleotides, which are necessary for DNA synthesis. Because of this medication, DNA replication is halted in the S-phase of the cell cycle. Hydroxyurea is indicated for use in chronic myelogenous leukemia (CML), melanoma, and in sickle cell disease. Notable side effects of this drug inlcude gastrointestinal distress, as well as myelosuppression.
9 KEY FACTS
MECHANISM
Inhibits Ribonucleotide Reductase
Inhibiting-chains on Red-duck

This medication works through inhibition of the enzyme ribonucleotide reductase. This enzyme reduces ribonucleotides into deoxyribonucleotides, which are necessary for DNA synthesis.

Decreased DNA Synthesis
Down-arrow DNA Building

By inhibiting ribonucleotide reductase with hydroxyurea, DNA synthesis is decreased.

S-phase Specific
S Building

Hydroxyurea leads to prolonged inhibition of DNA replication, and as a result, cellular division is arrested in the S phase. This is also known as activating the S phase "checkpoint." Thus, by inhibiting DNA replication, hydroxyurea stops or severely slows down the cell replication cycle.

INDICATIONS
Melanoma
Melon-gnome

This medication is also used to treat malignant melanoma.

Chronic Myelogenous Leukemia (CML)
CaMeL

This medication is used to treat chronic myelogenous leukemia (CML). Its use has been largely replaced by imatinib, but is still used because of cost-effectiveness.

Sickle Cell Disease
Sickle

Hydroxyurea is a mainstay of therapy in sickle cell disease, because it effectively reverses sickling of cells. It causes an increase of Fetal hemoglobin (HbF), and inhibits Hemoglobin S (HbS) aggregation.

Through Increased HbF (Fetal Hemoglobin)
He-man-globe with Fetus

This drug enhances fetal hemoglobin (HbF) production. Fetal hemoglobin's reduction in the severity of the disease comes from its ability to inhibit the formation of hemoglobin aggregates within red blood cells that contain hemoglobin S (HbS), which is seen in sickle cell anemia.

SIDE EFFECTS
Myelosuppression
Red and White blood cells Supressed

A very common side effect of hydroxyurea is bone marrow depression; patients often develop neutropenia and thrombocytopenia. Hematologic recovery usually happens 2 weeks after stopping medications administration, however.

GI Distress
GI with Flare-gun

Hydroxyurea can lead to acute mucocutaneous toxicity. Patients can have severe GI distress, with diarrhea, constipation, nausea and vomiting.

Unlock all 9 facts & definitions with Picmonic Free!

JOIN FREE

Take the Hydroxyurea Quiz

Picmonic's rapid review multiple-choice quiz allows you to assess your knowledge.

START QUIZ NOW

It's worth every penny

Our Story Mnemonics Increase Mastery and Retention

Memorize facts with phonetic mnemonics

Unforgettable characters with concise but impactful videos (2-4 min each)

Ace Your Medical (MD/DO) Classes & Exams with Picmonic:

Over 870,000 students use Picmonic’s picture mnemonics to improve knowledge, retention, and exam performance.

Choose the #1 Medical (MD/DO) student study app.

Picmonic for Medicine (MD/DO) covers information that is relevant to your entire Medical (MD/DO) education. Whether you’re studying for your classes or getting ready to conquer the USMLE Step 1, USMLE Step 2 CK, COMLEX Level 1, or COMLEX Level 2, we’re here to help.

Works better than traditional Medical (MD/DO) flashcards.

Research shows that students who use Picmonic see a 331% improvement in memory retention and a 50% improvement in test scores.