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Bevacizumab Side Effects

Beaver-scissor-mob with Side-fx
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6 KEY FACTS
Impaired (Delayed) Wound Healing
Bandaged Wounds

By inhibiting the growth of new blood vessels , Bevacizumab inhibits the ability to heal wounds.  Any incisions made during surgical procedures may slow to heal or not fully heal because of these anti-angiogenic effects.  Patients taking Bevacizumab must stop taking this medication 28 days before or 28 days after surgery until any incisions have fully healed.

Hemorrhage
Hemorrhage-hammer

Patients can experience vomiting or coughing up blood (hematemesis or hemoptysis), bleeding in the GI tract, epistaxis (nosebleeds), abnormal vaginal bleeding, gingival bleeding, and bleeding in the brain or spinal cord.  This medication is contraindicated in patients with recent hemoptysis or hemorrhage.

Nosebleed (Epistaxis)
Bleeding Nose

Nosebleeds, or epistaxis, are one of the most common effects of Bevacizumab and patients should notify their doctor if this or any other signs of abnormal or excessive bleeding occur. 

GI Perforation
GI Perforated

GI perforation is a hole that develops through the wall of any part of the gastrointestinal tract and is considered a medical emergency.  Contents of the GI tract will leak into surrounding cavities and cause infection.

Thromboembolic Event
Trombone with Thromboembolic Event

Arterial thromboembolic events such as myocardial or cerebral infarctions are one of the more severe side effects.

Osteonecrosis of the Jaw
Necrosis-crow with Jaw bone

Death of bone in the jaw is seen in some patients taking Bevacizumab and in patients taking bisphosphonates in conjunction with chemotherapy regimes. 

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