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Memantine

Mummy-tin
Picmonic
Memantine is an NMDA receptor antagonist drug, which helps prevent excitotoxicity in patients with Alzheimer's disease. It is a glutamergic antagonist at NMDA receptors. This medication works by halting an influx of Ca2+, preventing excitotoxicity to neurons. Neuronal excitotoxicity is mediated by Ca2+, which activates intracellular enzymes, leading to cell destruction. Thus, by halting this influx, memantine shows symptomatic improvement in patients. This drug has been shown to have a modest effect on moderate and severe Alzheimer's cases, while having little benefit in mild cases of Alzheimer's disease. Though rare, patients taking memantine can experience the side effects of confusion and hallucinations.
5 KEY FACTS
INDICATIONS
Alzheimer's Disease
Old-timer

Memantine is an NMDA receptor antagonist drug which helps prevent excitotoxicity in patients with Alzheimer's.

MECHANISM OF ACTION
NMDA Receptor Antagonist
NMDA Receptor Ant-toga

Memantine is a glutamatergic antagonist at NMDA receptors.  This action allows to impede an influx of Ca2+, halting excitotoxicity to neurons. This drug is low affinity and short-acting with a modest effect.

Prevents Excitotoxicity
Blocking Excited-X-toxic nerves

By antagonizing NMDA receptors, excitotoxicity is prevented in neurons. Excitotoxicity is mediated by Ca2+ which activates intracellular enzymes, leading to cell destruction.

SIDE EFFECTS
Confusion
Confucius

An adverse effect of treatment with memantine is confusion in patients.

Hallucinations
Halloween-hallucination

Patients taking memantine can suffer from hallucinations.

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