Octreotide is used to treat acute variceal bleeds, as this somatostatin-analog induces splanchnic constriction. This leads to decreased portal vessel pressure in bleeding varices.
Octreotide inhibits the action of certain hormones from the anterior pituitary, such as TSH and GH. Thus, this medication is helpful in tumors producing TSH (thyrotropinoma) and GH (gigantism and acromegaly).
Octreotide is helpful in treating gigantism and acromegaly, as this medication inhibits the secretion of GH from the anterior pituitary.
This medication is helpful in carcinoid syndrome, as octreotide decreases the secretion of serotonin by the tumor and decreases the breakdown product of serotonin.
Octreotide is used to control the diarrhea associated with VIPomas, as this medication blocks the secretion and action of vasoactive intestinal peptide (VIP).
Octreotide is a long-acting octapeptide which mimics somatostatin, a natural hormone which inhibits several endocrine processes.
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