The H2 blocking medications, cimetidine and ranitidine inhibit tubular transport of creatinine, preventing its clearance. This leads to increased serum creatinine levels.
Cimetidine is a specific H2 blocking medication, which is known to have side effects of crossing the blood-brain barrier, anti-androgenic effects and potent inhibition of cytochrome P450.
Cimetidine crosses the blood-brain barrier, and can lead to effects such as confusion, headache and dizziness. In addition to crossing the blood-brain barrier, cimetidine has the potential to cross the placenta and affect the fetus.
Cimetidine has anti-androgenic properties, acting as a competitive antagonist at DHT receptors. This leads to exaggerated effects of estrogen, manifesting as galactorrhea and amenorrhea in women, and impotence and gynecomastia in men.
Cimetidine is a potent inhibitor of the cytochrome P450 enzyme system. Thus, multiple drug interactions may occur with its administration, as it decreases metabolism of particular medications.
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