Master Fibrates with Picmonic for Medicine

With Picmonic, facts become pictures. We've taken what the science shows - image mnemonics work - but we've boosted the effectiveness by building and associating memorable characters, interesting audio stories, and built-in quizzing.

Fibrates

Fly-Brats
Picmonic
Fibrates are carboxylic acid medications indicated for use in hyperlipidemia and other dyslipidemias. These drugs work via many mechanisms, leading to decreased triglycerides, slight increases in HDL and slight decreases in LDL. Fibrates lead to upregulation of LPL, allowing accessibility to triglyceride-rich lipoproteins for lipolysis. Another mechanism they work by is increasing hepatic uptake of fatty acids and decreasing hepatic production of triglycerides, decreasing their overall plasma levels. A slight increase in HDL is caused by increased amounts of Apoproteins A-1 and A-II, which allow more effecient reverse cholesterol transport. A slight decrease in LDL is seen with fibrate administration due to formation of LDL with a higher affinity for its receptor, allowing it to be catabolized quicker. Side effects of fibrate drugs include hepatotoxicity and increased LFT values, as well as cholesterol gallstones, which is due to increased cholesterol content in bile. Other side effects include myalgias, increased CPK, and resulting acute kidney injury.
7 KEY FACTS
INDICATIONS
Hyperlipidemia
Hiker-lips

This drug is indicated for treating hyperlipidemia, which refers to abnormally high levels of lipids or lipoproteins in the blood. Fibrates are also used for other dyslipidemias, such as hypertriglyceremia.

MECHANISM OF ACTION
Upregulate LPL
Up-regulator Lip-laser

Fibrates upregulate lipoprotein lipase, which is required for triglyceride metabolism in the blood.

Decreases Triglycerides
Down-arrow TAG-triceratops

Triglyceride (TAG) levels are decreased through treatment by fibrates because these drugs increase accessibility triglyceride-rich lipoprotein to be hydrolized by lipoprotein lipase. Another mechanism by which TAGs are decreased is inducing hepatic fatty acid uptake and reducing hepatic triglyceride production.

Slight Increase in HDL
Small Up-arrow Hot-dog-angel

Fibrates increase production of apoA-I and apoA-II in the liver. This leads to an increase of plasma HDL concentrations and a more efficient reverse cholesterol transport.

Slight Decrease in LDL
Small Down-arrow Ladybug

Treatment with these medications forms LDL which has a higher affinity for its receptor, and are consequentially broken down more rapidly.

SIDE EFFECT
Hepatotoxicity
Liver with Toxic-green-glow

Treatment with these drugs may lead to hepatotoxicity and increased liver function test (LFTs) values. Other side effects include myopathy, increased CPK, and renal failure.

Cholesterol Gallstones
Cholesterol-burgers wih Gold-stones

As these drugs increase the cholesterol content of bile, there is an increased risk of cholesterol gallstones.

Unlock all 7 facts & definitions with Picmonic Free!

JOIN FREE

Take the Fibrates Quiz

Picmonic's rapid review multiple-choice quiz allows you to assess your knowledge.

START QUIZ NOW

It's worth every penny

Our Story Mnemonics Increase Mastery and Retention

Memorize facts with phonetic mnemonics

Unforgettable characters with concise but impactful videos (2-4 min each)

Ace Your Medical (MD/DO) Classes & Exams with Picmonic:

Over 870,000 students use Picmonic’s picture mnemonics to improve knowledge, retention, and exam performance.

Choose the #1 Medical (MD/DO) student study app.

Picmonic for Medicine (MD/DO) covers information that is relevant to your entire Medical (MD/DO) education. Whether you’re studying for your classes or getting ready to conquer the USMLE Step 1, USMLE Step 2 CK, COMLEX Level 1, or COMLEX Level 2, we’re here to help.

Works better than traditional Medical (MD/DO) flashcards.

Research shows that students who use Picmonic see a 331% improvement in memory retention and a 50% improvement in test scores.