These medications are used to treat HIV and AIDS.
These medications are different from NRTIs, as they do not require intracellular metabolism, or phosphorylation "activation" to work against HIV.
These drugs work by binding to reverse transcriptase (at a different site from NRTIs), preventing viral DNA from being transcripted.
Patients taking NNRTIs can often complain about developing rashes. This mainly occurs in female patients.
Hepatotoxicity is a common side effect of NNRTI drug therapy, and patients should have their liver function monitored.
Patients taking these medications have complained of vivid dreams and CNS symptoms (dizziness, confusion). The NNRTI medication efavirenz is known to cause these effects.
NNRTI medications, most notably delavirdine and efavirenz are contraindicated in pregnancy, and can lead to teratogenic effects.
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